Signals delivered through TCR instruct IL-12 receptor (IL-12R) expression: IL-12 and tumor necrosis factor-α synergize for IL-12R expression at low antigen dose

International Immunology

Volumn 13, Issue 11, 2001, Pages 1433-1442

  Ahlers, J D ^a   Belyakov, I M ^a   Matsui, S ^a   Berzofsky, J A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cellular activation; Cytokine receptors; T lymphocyte Th1 Th2

Indexed keywords

ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 12 RECEPTOR BETA CHAIN; MONOCLONAL ANTIBODY CD3; OVALBUMIN; PEPTIDE; PLASTIC; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; GENE CONTROL; GENE FUNCTION; INTERFERON PRODUCTION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STIMULUS; T LYMPHOCYTE;

EID: 0035158344     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/13.11.1433     Document Type: Article

References (29)

1. Cytokines induce the development of functionally heterogeneous T helper cell subsets
2. Dealing from the evolutionary pawnshop: Review how lymphocytes make decisions
3. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
4. h2 lineage by extinction of IL-12 signaling
5. Selective expression of an interleukin-12 receptor component by human T helper 1 cells
6. Regulation of interleukin (IL)-12 receptor B2 subunit expression by endogenous IL-12: A critical step in the differentiation of pathogenic autoreactive T cells
7. Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs: GM-CSF and TNF-α synergize with IL-12 to enhance induction of CTL
8. h1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFKB
9. h1 cells producing high levels of IFN-γ in BALB/c but not C57BL/6 mice
10. T cell genetic background determines default T helper phenotype development in vitro
11. h cell polarization
12. + T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model
13. h2 cytokine balance
14. Helper T cell differentiation is controlled by the cell cycle
15. Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression
16. Mechanisms of cytokine synergy essential for vaccine protection against viral challenge
17. h2 cells
18. H2 cell antigen receptors in experimental leishmaniasis
19. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
20. Differential effects of CD28 engagement and IL-12 on T cell activation by altered peptide ligands
21. h1 lineage commitment
22. h2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression
23. h2 cytokines
24. h2 development and commitment
25. T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor β2 chain expression and signaling
26. h2 cells does not affect the production of IL-4 or induce the production of IFN-γ
27. + T cells by antigenic peptides altered for TCR binding
28. Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific cytotoxic T lymphocytes
29. Changes in the strength of co-stimulation through the B7/CD28 pathway alter functional T cell responses to altered peptide ligands