Impairment of Gag-specific CD8+ T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaques

Journal of Virology

Volumn 75, Issue 23, 2001, Pages 11483-11495

  Hel, Z ^a   Nacsa, J ^a   Kelsall, B ^a   Tsai, W P ^a   Letvin, N ^a   Parks, R W ^a   Tryniszewska, E ^a   Picker, L ^a   Lewis, M G ^a   Edghill Smith, Y ^a   Moniuszko, M ^a   Pal, R ^a   Stevceva, L ^a   Altman, J D ^a   Allen, T M ^a   Watkins, D ^a   Torres, J V ^a   Berzofsky, J A ^a   Belyakov, I M ^a   Strober, W ^a   Franchini, G ^a   more..

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAG PROTEIN; TETRAMER;

ANIMAL CELL; ANIMAL MODEL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CELL FUNCTION; CELL POPULATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE COURSE; INFECTION CONTROL; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; VIREMIA; VIRUS REPLICATION; VIRUS STRAIN;

ANIMALS; CD4 LYMPHOCYTE COUNT; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHIMERA; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE PRODUCTS, GAG; HIV; IMMUNITY, MUCOSAL; INTERFERON TYPE II; MACACA MULATTA; ORGAN SPECIFICITY; SIMIAN IMMUNODEFICIENCY VIRUS; TUMOR NECROSIS FACTOR-ALPHA; VIREMIA; VIRUS REPLICATION;

EID: 0035167278     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.23.11483-11495.2001     Document Type: Article

References (47)

1. + lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule mamu-A*01: Implications for vaccine design and testing
2. Phenotypic analysis of antigen-specific T lymphocytes
3. HIV-specific CD8+ T cells produce antiviral cytokines but are impaired in cytolytic function
4. + cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12
5. Hypoproliferative human lamina propria T cells retain the capacity to secrete lymphokines when stimulated via CD2/CD28 pathways
6. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
7. Progressive loss of CDS+ T cell-mediated control of a γ-herpesvirus in the absence of CD4+ T cells
8. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: Differential CTL responses to HIV-1 and Epstein-Barr virus in late disease
9. Simian immunodeficiency virus evades a dominant epitope-specific cytotoxic T lymphocyte response through a mutation resulting in the accelerated dissociation of viral peptide and MHC class I
10. Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein
11. Direct measurement of CD8+ T cell responses in macaques infected with simian immunodeficiency virus
12. A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon
13. Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children
14. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
15. Effective induction of simian immunodeficiency virus-specific cyotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen
16. Primary acute simian immunodeficiency virus infection of intestinal lymphoid tissue is associated with gastrointestinal dysfunction
17. 251 infection of macaques
18. Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques
19. Chimeric SHIV that causes CD4+ T cell loss and AIDS in rhesus macaques
20. Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: A longitudinal analysis of rapid progressors and long-term asymptomatics
21. Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression
22. + T cell expansions: Evidence for impaired CTL effector function
23. Simian immunodeficiency virus-specific cytotoxic T lymphocytes and cell-associated viral RNA levels in distinct lymphoid compartments of SIVmac-infected rhesus monkeys
24. Analysis of successful immune responses in persons infected with hepatitis C virus
25. Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques
26. + T-cell depletion in primary, simian immunodeficiency virus infection
27. Mucosal phenotype of antiviral cytotoxic T lymphocytes in the vaginal mucosa of SIV-infected rhesus macaques
28. Selective induction of protective MHC class I-restricted CTL in the intestinal lamina propria of rhesus monkeys by transient SIV infection of the colonic mucosa
29. HIV-1 Gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides
30. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
31. In vivo cell and tissue tropism of SIVsmmPBj14-bcl.3
32. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia
33. Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV
34. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition
35. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection
36. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors
37. Vigorous HIV-1-specific CD4+ T-cell responses associated with control of viremia
38. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
39. Simian immunodeficiency virus (SIV)-specific CTL are present in large numbers in livers of SIV-infected rhesus monkeys
40. Quantification of HIV-1-specific T-cell responses at the mucosal cervicovaginal surface
41. + T cells in chronic human immunodeficiency virus infection
42. Human-immunodeficiency virus-specific circulating CD8 T lymphocytes have down-modulated CD3zeta and CD28, key signaling molecules for T-cell activation
43. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection
44. Functional impairment of simian immunodeficiency virus-specific CD8+ T cells during the chronic phase of infection
45. Adaptive evolution of human immunodeficlency virus-type 1 during the natural course of infection
46. A vaccine-elicited, single viral epitope-specific cytotoxic T-lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge
47. Viral immune evasion due to persistence of activated T cells without effector function