The induction of systemic and mucosal immune responses to antigen-adjuvant compositions administered into the skin: Alterations in the migratory properties of dendritic cells appears to be important for stimulating mucosal immunity

Vaccine

Volumn 18, Issue 24, 2000, Pages 2753-2767

  Enioutina, Elena Y ^a   Visic, Dino ^a   Daynes, Raymond A ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Dendritic cells; Mucosal immunity; Vitamin D3

Indexed keywords

ADJUVANT; BACTERIAL TOXIN; CALCITRIOL; DIPHTHERIA TOXIN; ENTEROTOXIN; PERTUSSIS TOXIN; VACCINE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; IMMUNE RESPONSE; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL;

EID: 0034212408     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(00)00059-1     Document Type: Article

References (56)

1. McGhee J.R., Kiyono H. New perspectives in vaccine development: mucosal immunity to infections. Infect. Agents Dis. 2:(2):1993;55-73.
2. Mestecky J. The common mucosal immune system and current strategies for induction of immune responses in external secretions. J. Clin. Immunol. 7:(4):1987;265-276.
3. Ruedl C., Rieser C., Kofler N., Wick G., Wolf H. Humoral and cellular immune responses in the murine respiratory tract following oral immunization with cholera toxin or Escherichia coli heat-labile enterotoxin. Vaccine. 14:(8):1996;792-798.
4. Freytag L.C., Clements J.D. Bacterial toxins as mucosal adjuvants. Curr. Top Microbiol. Immunol. 236:1999;215-236.
5. Takahashi I., Marinaro M., Kiyono H., et al. Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin. J. Infec. Dis. 173:(3):1996;627-635.
6. Di Tommaso A., Saletti G., Pizza M., et al. Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant. Infect. Immun. 64:(3):1996;974-979.
7. Yamamoto M., McDaniel L.S., Kawabata K., et al. Oral immunization with PspA elicits protective humoral immunity against Streptococcus pneumoniae infection. Infect. Immun. 65:(2):1997;640-644.
8. Isaka M., Yasuda Y., Kozuka S., et al. Systemic and mucosal immune responses of mice to aluminium-adsorbed or aluminium-non-adsorbed tetanus toxoid administered intranasally with recombinant cholera toxin B subunit. Vaccine. 16:(17):1998;1620-1626.
9. Girard F., Pery P., Naciri M., Quere P. Adjuvant effect of cholera toxin on systemic and mucosal immune responses in chickens infected with E. tenella or given recombinant parasitic antigen per os. Vaccine. 17:(1112):1999;1516-1524.
10. Hartman A.B., Van De Verg L.L., Venkatesan M.M. Native and mutant forms of cholera toxin and heat-labile enterotoxin effectively enhance protective efficacy of live attenuated and heat-killed Shigella vaccines. Infect. Immun. 67:(11):1999;5841-5847.
11. Bergquist C., Lagergard T., Holmgren J. Antibody responses in serum and lung to intranasal immunization with Haemophilus influenzae type b polysaccharide conjugated to cholera toxin B subunit and tetanus toxoid. Apmis. 106:(8):1998;800-806.
12. Wu H.-Y., Russell M.W. Induction of mucosal immunity by intranasal application of a streptococcal surface protein antigen with the cholera toxin B subunit. Infect. Immun. 61:(1):1993;314-322.
13. Wu H.Y., Russell M.W. Induction of mucosal and systemic immune responses by intranasal immunization using recombinant cholera toxin B subunit as an adjuvant. Vaccine. 16:(23):1998;286-292.
14. Daynes R.A., Enioutina E.Y., Butler S., Mu H.H., McGee Z.A., Araneo B.A. Induction of common mucosal immunity by hormonally immunomodulated peripheral immunization. Infect. Immun. 64:(4):1996;1100-1109.
15. Glenn G.M., Scharton-Kersten T., Vassell R., Mallett C.P., Hale T.L., Alving C.R. Transcutaneous immunization with cholera toxin protects mice against lethal mucosal toxin challenge. J. Immunol. 161:(7):1998;3211-3214.
16. Glenn G.M., Scharton-Kersten T., Vassell R., Matyas G.R., Alving C.R. Transcutaneous immunization with bacterial ADP-ribosylating exotoxins as antigens and adjuvants. Infect. Immun. 67:(3):1999;1100-1106.
17. Inaba K., Inaba M., Romani N., et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:(6):1992;1693-1702.
18. Yang S., Darrow T.L., Vervaert C.E., Seigler H.F. Immunotherapeutic potential of tumor antigen-pulsed and unpulsed dendritic cells generated from murine bone marrow. Cell Immunol. 179:(1):1997;84-95.
19. Enioutina E.Y., Visic D., McGee Z.A., Daynes R.A. The induction of systemic and mucosal immune responses following the subcutaneous immunization of mature adult mice: characterization of the antibodies in mucosal secretions of animals immunized with antigen formulations containing a vitamin D3 adjuvant. Vaccine. 17:(2324):1999;3051-3066.
20. Williams N.A., Hirst T.R., Nashar T.O. Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic. Immunol. Today. 20:(2):1999;95-101.
21. Rodighiero C., Aman A.T., Kenny M.J., Moss J., Lencer W.I., Hirst T.R. Structural basis for the differential toxicity of cholera toxin and Escherichia coli heat-labile enterotoxin. Construction of hybrid toxins identifies the A2-domain as the determinant of differential toxicity. J. Biol. Chem. 274:(7):1999;3962-3969.
22. Kuziemko G.M., Stroh M., Stevens R.C. Cholera toxin binding affinity and specificity for gangliosides determined by surface plasmon resonance. Biochem. 35:(20):1996;6375-6384.
23. Steinman R.M. Dendritic Cells. Paul W.E. Fundamental Immunology. 4th ed. 1999;547-573 Lippincott-Raven, Philadelphia.
24. Wykes M., Pombo A., Jenkins C., MacPherson G.G. Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response. J. Immunol. 161:(3):1998;1313-1319.
25. Hart D.N. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood. 90:(9):1997;3245-3287.
26. Chin J., Gil F.S., Novak M., et al. Manipulating systemic and mucosal immune responses with skin-deliverable adjuvants. J. Biotechnol. 44:(13):1996;13-19.
27. Lycke N., Tsuji T., Holmgren J. The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity. Eur. J. Immunol. 22:(9):1992;2277-2281.
28. Blanchard T.G., Lycke N., Czinn S.J., Nedrud J.G. Recombinant cholera toxin B subunit is not an effective mucosal adjuvant for oral immunization of mice against Helicobacter felis. Immunol. 94:(1):1998;22-27.
29. Johansson E.L., Rask C., Fredriksson M., Eriksson K., Czerkinsky C., Holmgren J. Antibodies and antibody-secreting cells in the female genital tract after vaginal or intranasal immunization with cholera toxin B subunit or conjugates. Infect. Immun. 66:(2):1998;514-520.
30. Holmgren J., Lycke N., Czerkinsky C. Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems. Vaccine. 11:(12):1993;1179-1184.
31. Lebens M., Holmgren J. Mucosal vaccines based on the use of cholera toxin B subunit as immunogen and antigen carrier. Dev. Biol. Stand. 82:1994;215-227.
32. Lycke N. The mechanism of cholera toxin adjuvanticity. Res. Immunol. 148:(89):1997;504-520.
33. Brodsky A., Davio C., Shayo C., et al. Forskolin induces U937 cell line differentiation as a result of a sustained cAMP elevation. Eur. J. Pharmacol. 350:(1):1998;121-127.
34. Manolopoulos V.G., Samet M.M., Lelkes P.I. Regulation of the adenylyl cyclase signaling system in various types of cultured endothelial cells. J. Cell Biochem. 57:(4):1995;590-598.
35. 3. Biochem. Biophys. Res. Comm. 249:(1):1998;11-16.
36. Kong X.F., Zhu X.H., Pei Y.L., Jackson D.M., Holick M.F. Molecular cloning, characterization, and promoter analysis of the human 25-hydroxyvitamin D3-1alpha-hydroxylase gene. Proc. Natl. Acad. Sci. USA. 96:(12):1999;6988-6993.
37. Menge A.C., Michalek S.M., Russell M.W., Mestecky J. Immune response of the female rat genital tract after oral and local immunization with keyhole limpet hemocyanin conjugated to the cholera toxin B subunit. Infect. Immun. 61:(5):1993;2162-2171.
38. Soesatyo M., Van den Dobbelsteen G.P., Van Rees E.P., Biewenga J., Sminia T. The in vivo antibody response in rat gut-associated lymphoid tissue (GALT) after immunization with bacterial polysaccharide antigen. Res. Immunol. 144:(2):1993;121-128.
39. Hill S., Edwards A.J., Kimber I., Knight S.C. Systemic migration of dendritic cells during contact sensitization. Immunol. 71:(2):1990;277-281.
40. Kripke M.L., Munn C.G., Jeevan A., Tang J.M., Bucana C. Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. J. Immunol. 145:(9):1990;2833-2838.
41. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature. 392:(6673):1998;245-252.
42. Kampgen E., Koch N., Koch F., et al. Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture. Proc. Natl. Acad. Sci. USA. 88:(8):1991;3014-3018.
43. Caux C., Vanbervliet B., Massacrier C., et al. B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J. Exp. Med. 180:(5):1994;1841-1847.
44. Aiba S. Maturation of dendritic cells induced by cytokines and haptens. Tohoku. J. Exp. Med. 184:(3):1998;159-172.
45. Sornasse T., Flamand V., De Becker G., et al. Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo. J. Exp. Med. 175:(1):1992;15-21.
46. D'Ambrosio D., Cippitelli M., Cocciolo M.G., et al. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J. Clin. Invest. 101:(1):1998;252-262.
47. Wu Y., Craig T.A., Lutz W.H., Kumar R. Identification of 1 alpha,25-dihydroxyvitamin D3 response elements in the human transforming growth factor beta 2 gene. Biochem. 38:(9):1999;2654-2660.
48. Wu Y., Haugen J.D., Zinsmeister A.R., Kumar R. 1 alpha,25-Dihydroxyvitamin D3 increases transforming growth factor and transforming growth factor receptor type I and II synthesis in human bone cells. Biochem. Biophys. Res. Comm. 239:(3):1997;734-739.
49. Iwasato T., Kanari Y., Shimizu A., Honjo T., Yamagishi H. Transforming growth factor-beta induced class switch recombination may be modified during the cell proliferation restored by IL-2 stimulation. Immunol. Lett. 39:(2):1994;173-178.
50. Zan H., Cerutti A., Dramitinos P., Schaffer A., Casali P. CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-β: evidence for TGF-β but not IL-10-dependent direct Sμ→Sα and sequential Sμ→Sγ, Sγ→Sα DNA recombination. J. Immunol. 161:(10):1998;5217-5225.
51. Gyetko M.R., Hsu C.H., Wilkinson C.C., Patel S., Young E. Monocyte 1 alpha-hydroxylase regulation: induction by inflammatory cytokines and suppression by dexamethasone and uremia toxin. J. Leukocyte Biol. 54:(1):1993;17-22.
52. Kreutz M., Andreesen R., Krause S.W., Szabo A., Ritz E., Reichel H. 1,25-dihydroxyvitamin D3 production and vitamin D3 receptor expression are developmentally regulated during differentiation of human monocytes into macrophages. Blood. 82:(4):1993;1300-1307.
53. Mawer E.B., Hayes M.E., Heys S.E., et al. Constitutive synthesis of 1,25-dihydroxyvitamin D3 by a human small cell lung cancer cell line. J. Clin. Endocrinol. Metab. 79:(2):1994;554-560.
54. Fu G.K., Lin D., Zhang M.Y., et al. Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol. Endocrinol. 11:(13):1997;1961-1970.
55. Bourguin I., Moser M., Buzoni-Gatel D., et al. Murine dendritic cells pulsed in vitro with Toxoplasma gondii antigens induce protective immunity in vivo. Infect. Immun. 66:(10):1998;4867-4874.
56. Flohe S.B., Bauer C., Flohe S., Moll H. Antigen-pulsed epidermal Langerhans cells protect susceptible mice from infection with the intracellular parasite Leishmania major. Eur. J. Immunol. 28:(11):1998;3800-3811.