Cutting edge: Transcutaneous immunization with cholera toxin protects mice against lethal mucosal toxin challenge

Journal of Immunology

Volumn 161, Issue 7, 1998, Pages 3211-3214

  Glenn, Gregory M ^a,b   Scharton Kersten, Tanya ^a,b   Vassell, Russell ^a,b   Mallett, Corey P ^a,c   Hale, Thomas L ^a   Alving, Carl R ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b IOMAI Corporation   (United States)

^c Intellivax Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; CHOLERA VACCINE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; BACTERIUM ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CHOLERA; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES ANALYSIS; IMMUNIZATION; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT MUCOSA; SERUM; TRANSDERMAL DRUG ADMINISTRATION; VIBRIO CHOLERAE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; C57BL MOUSE; IMMUNOLOGY; INTERSTITIAL LUNG DISEASE; INTRADERMAL DRUG ADMINISTRATION; INTRANASAL DRUG ADMINISTRATION; KINETICS; METHODOLOGY; MORTALITY; MUCOSAL IMMUNITY; ORAL DRUG ADMINISTRATION; VACCINATION;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, BACTERIAL; CHOLERA TOXIN; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; KINETICS; LUNG DISEASES, INTERSTITIAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; VACCINATION;

EID: 0032184817     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. De, S. N. 1959. Enterotoxicity of bacteria-free culture filtrate of Vibrio cholerae. Nature 183:1533.
2. Levine, M. M., J. B. Kaper, R. E. Black, and M. L. Clemens. 1983. New knowledge on pathogenesis of bacterial infections as applied to vaccine development. Microbiol. Rev. 47:510.
3. Snider, D. P. 1995. The mucosal adjuvant activities of ADP-bacterial enterotoxins. Crit. Rev. Immunol. 15:317.
4. Holmgren, J., and A.-M. Svennerholm. 1977. Mechanisms of disease and immunity in cholera: a review. J. Infect. Dis. 136:5105.
5. Clemens, J. D., D. A. Sack, J. R. Harris, J. Chakraborty, M. R. Khan, B. F. Stanton, B. A. Kay, M. U. Khan, M. Yunus, W. Atkinson, et al. 1986. Field trial of oral cholera vaccines in Bangladesh. Lancet 2:124.
6. Glenn, G. M., M. Rao, G. R. Matyas, and C. R. Alving. 1998. Cholera toxin opens up skin immunization route. Nature 391:851.
7. Glenn, G. M., M. R. Rao, R. L. Richards, G. R. Matyas, and C. R. Alving. 1995. Murine IgG subclass antibodies to antigens incorporated in liposomes containing lipid A. Immunol. Lett. 47:73.
8. Clemens, J., M. Jertborn, D. Sack, B. Stanton, J. Holmgren, M. R. Khan, and S. Huda. 1986. Effect of neutralization of gastric acid on immune responses to an oral B subunit, killed whole-cell vaccine. J. Infect. Dis. 154:175.
9. Schneerson, R. E., J. B. Robbins, J. Taranger, T. Lagergaard, and B. Trollfors. 1996. A toxoid vaccine for pertussis as well as diphtheria? Lessons to be relearned. Lancet 348:1289.
10. Clemens, J. D., D. A. Sack, J. R. Harris, J. Chakraborty, P. K. Neogy, B. F. Stanton, N. Huda, M. U. Khan, B. A. Kay, M. R. Khan, M. Ansaruzzaman, M. D. Yunus, M. R. Rao, A.-M. Svennerholm, and J. Holmgren. 1988. Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: results of a large-scale field trial. J. Infect. Dis. 158:372.
11. Pierce, N. F., W. C. Cray, and P. F. Engel. 1980. Antitoxic immunity to cholera in dogs immunized orally with cholera toxin. Infect. Immun. 27:632.
12. Holmgren, J., A.-M. Svennerholm, O. Ouchterlony, A. Andersen, G. Wallerstrom, and U. Westerberg-Berndtsson. 1975. Antitoxic immunity in experimental cholera: comparison of immunity induced perorally and parenterally in mice. J. Infect. Dis. 12:463.