Role of T cells in ovariectomy induced bone loss-revisited

Journal of Bone and Mineral Research

Volumn 27, Issue 2, 2012, Pages 231-239

  Pacifici, Roberto ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 7; OSTEOCLAST DIFFERENTIATION FACTOR; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR;

ANTIGEN PRESENTATION; APOPTOSIS; BONE DENSITY; BONE MARROW; BONE REMODELING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL INTERACTION; CELL MATURATION; CELL PROLIFERATION; CYTOKINE RELEASE; DENDRITIC CELL; ENDOPLASMIC RETICULUM; ESTROGEN DEFICIENCY; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOCYTE; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; OVARY FUNCTION; POSTMENOPAUSE OSTEOPOROSIS; REGULATORY T LYMPHOCYTE; REVIEW; RHEUMATOID ARTHRITIS; STROMA CELL; T CELL DEPLETION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMUS FUNCTION;

EID: 84856148387     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1500     Document Type: Review

References (114)

1. Cenci S, Weitzmann MN, Roggia C, Namba N, Novack D, Woodring J, Pacifici R,. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest. 2000; 106 (10): 1229-37.
2. Manolagas SC, Kousteni S, Jilka RL,. Sex steroids and bone. Recent Prog Horm Res. 2002; 57: 385-409.
3. Weitzmann MN, Pacifici R,. Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest. 2006; 116 (5): 1186-94.
4. Di Gregorio GB, Yamamoto M, Ali AA, Abe E, Roberson P, Manolagas SC, Jilka RL,. Attenuation of the self-renewal of transit-amplifying osteoblast progenitors in the murine bone marrow by 17 beta-estradiol. J Clin Invest. 2001; 107 (7): 803-12. (Pubitemid 32274033)
5. Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S,. Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell. 2007; 130 (5): 811-23. (Pubitemid 47332572)
6. Krum SA, Miranda-Carboni GA, Hauschka PV, Carroll JS, Lane TF, Freedman LP, Brown M,. Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. EMBO J. 2008; 27 (3): 535-45. (Pubitemid 351225684)
7. Martin-Millan M, Almeida M, Ambrogini E, Han L, Zhao H, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC,. The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol. 2010; 24 (2): 323-34.
8. Chen JR, Plotkin LI, Aguirre JI, Han L, Jilka RL, Kousteni S, Bellido T, Manolagas SC,. Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens. J Biol Chem. 2005; 280 (6): 4632-8. (Pubitemid 40288632)
9. Zaidi M,. Skeletal remodeling in health and disease. Nat Med. 2007; 13 (7): 791-801. (Pubitemid 47038187)
10. Manolagas SC,. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev. 2010; 31 (3): 266-300.
11. Jilka RL, Takahashi K, Munshi M, Williams DC, Roberson PK, Manolagas SC,. Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption. J Clin Invest. 1998; 101 (9): 1942-50. (Pubitemid 28226114)
12. Kousteni S, Bellido T, Plotkin LI, O'Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katzenellenbogen JA, Katzenellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC,. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell. 2001; 104 (5): 719-30. (Pubitemid 32241022)
13. Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T, Manolagas SC,. Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest. 2003; 111 (11): 1651-64. (Pubitemid 38057747)
14. Kimble RB, Srivastava S, Ross FP, Matayoshi A, Pacifici R,. Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1and tumor necrosis factor- mediated stimulation of macrophage colony-stimulating factor production. J Biol Chem. 1996; 271 (46): 28890-7. (Pubitemid 26382589)
15. Roggia C, Gao Y, Cenci S, Weitzmann MN, Toraldo G, Isaia G, Pacifici R,. Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo. Proc Natl Acad Sci U S A. 2001; 98 (24): 13960-5. (Pubitemid 33116006)
16. Gao Y, Qian WP, Dark K, Toraldo G, Lin AS, Guldberg RE, Flavell RA, Weitzmann MN, Pacifici R,. Estrogen prevents bone loss through transforming growth factor beta signaling in T cells. Proc Natl Acad Sci U S A. 2004; 101 (47): 16618-23. (Pubitemid 39557762)
17. Gao Y, Grassi F, Ryan MR, Terauchi M, Page K, Yang X, Weitzmann MN, Pacifici R,. IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest. 2007; 117 (1): 122-32. (Pubitemid 46048459)
18. Li JY, Tawfeek H, Bedi B, Yang X, Adams J, Gao KY, Zayzafoon M, Weitzmann MN, Pacifici R,. Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand. Proc Natl Acad Sci U S A. 2011; 108 (2): 768-73.
19. Grassi F, Tell G, Robbie-Ryan M, Gao Y, Terauchi M, Yang X, Romanello M, Jones DP, Weitzmann MN, Pacifici R,. Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Proc Natl Acad Sci U S A. 2007; 104 (38): 15087-92. (Pubitemid 47619597)
20. Moreland L, Bate G, Kirkpatrick P,. Abatacept. Nat Rev Drug Discov. 2006; 5 (3): 185-6. (Pubitemid 43336031)
21. Ruderman EM, Pope RM,. The evolving clinical profile of abatacept (CTLA4-Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis. Arthritis Res Ther. 2005; 7 (Suppl 2): S21-5. (Pubitemid 40936617)
22. Yamaza T, Miura Y, Bi Y, Liu Y, Akiyama K, Sonoyama W, Patel V, Gutkind S, Young M, Gronthos S, Le A, Wang CY, Chen W, Shi S,. Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents. PLoS One. 2008; 3 (7): e2615.
23. Lee SK, Kadono Y, Okada F, Jacquin C, Koczon-Jaremko B, Gronowicz G, Adams DJ, Aguila HL, Choi Y, Lorenzo JA,. T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res. 2006; 21 (11): 1704-2.
24. Anginot A, Dacquin R, Mazzorana M, Jurdic P,. Lymphocytes and the Dap12 adaptor are key regulators of osteoclast activation associated with gonadal failure. PLoS One. 2007; 2 (7): e585.
25. Robbie-Ryan M, Pacifici R, Weitzmann MN,. IL-7 drives T cell-mediated bone loss following ovariectomy. Ann N Y Acad Sci. 2006; 1068: 348-51. (Pubitemid 43824167)
26. DeSelm C, Takahata Y, Chappel J, Khan T, Li K, Zou W, Teitelbaum S,. IL-17 mediates estrogen-deficient osteoporosis. J Bone Miner Res. 2011; 27(Abstract FR0299).
27. Polanczyk MJ, Carson BD, Subramanian S, Afentoulis M, Vandenbark AA, Ziegler SF, Offner H,. Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment. J Immunol. 2004; 173 (4): 2227-30. (Pubitemid 39063075)
28. Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, Kadono Y, Tanaka S, Kodama T, Akira S, Iwakura Y, Cua DJ, Takayanagi H,. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med. 2006; 203 (12): 2673-82. (Pubitemid 44833343)
29. Lelu K, Laffont S, Delpy L, Paulet PE, Perinat T, Tschanz SA, Pelletier L, Engelhardt B, Guery JC,. Estrogen receptor alpha signaling in T lymphocytes is required for estradiol-mediated inhibition of Th1 and Th17 cell differentiation and protection against experimental autoimmune encephalomyelitis. J Immunol. 2011; 187 (5): 2386-93.
30. Goswami J, Hernandez-Santos N, Zuniga LA, Gaffen SL,. A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss. Eur J Immunol. 2009; 39 (10): 2831-9.
31. Kim YG, Lee CK, Nah SS, Mun SH, Yoo B, Moon HB,. Human CD4+CD25+ regulatory T cells inhibit the differentiation of osteoclasts from peripheral blood mononuclear cells. Biochem Biophys Res Commun. 357 (4): 1046-52.
32. Yuan FL, Li X, Lu WG, Xu RS, Zhao YQ, Li CW, Li JP, Chen FH,. 2010 Regulatory T cells as a potent target for controlling bone loss. Biochem Biophys Res Commun. 2007; 402 (2): 173-6.
33. Luo CY, Wang L, Sun C, Li DJ,. Estrogen enhances the functions of CD4(+)CD25(+)Foxp3(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro. Cell Mol Immunol. 2011; 8 (1): 50-8.
34. Tai P, Wang J, Jin H, Song X, Yan J, Kang Y, Zhao L, An X, Du X, Chen X, Wang S, Xia G, Wang B,. Induction of regulatory T cells by physiological level estrogen. J Cell Physiol. 2008; 214 (2): 456-64. (Pubitemid 350309002)
35. Zaiss MM, Sarter K, Hess A, Engelke K, Bohm C, Nimmerjahn F, Voll R, Schett G, David JP,. Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation. Arthritis Rheum. 2010; 62 (8): 2328-38.
36. Surh CD, Sprent J,. Homeostasis of naive and memory T cells. Immunity. 2008; 29 (6): 848-62.
37. Ernst B, Lee DS, Chang JM, Sprent J, Surh CD,. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity. 1999; 11 (2): 173-81. (Pubitemid 29428810)
38. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI,. Human nutrition, the gut microbiome and the immune system. Nature. 2011; 474 (7351): 327-36.
39. Sjögren K, Engdahl C, Lagerquist M, Bäckhed F, Ohlsson C,. Absence of gut microbiota leads to increased bone mass associated with low serum serotonin levels. J Bone Miner Res. 2010; 25: Abstract 1170.
40. Tyagi AM, Srivastava K, Sharan K, Yadav D, Maurya R, Singh D,. Daidzein prevents the increase in CD4CD28null T cells and B lymphopoesis in ovariectomized mice: a key mechanism for anti-osteoclastogenic effect. PLoS One. 2011; 6 (6): e21216.
41. Tyagi AM, Srivastava K, Kureel J, Kumar A, Raghuvanshi A, Yadav D, Maurya R, Goel A, Singh D,. Premature T cell senescence in Ovx mice is inhibited by repletion of estrogen and medicarpin: a possible mechanism for alleviating bone loss. Osteoporos Int. Epub 2011 May 12.
42. D'Amelio P, Grimaldi A, Di Bella S, Brianza SZ, Cristofaro MA, Tamone C, Giribaldi G, Ulliers D, Pescarmona GP, Isaia G,. Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis. Bone. 2008; 43 (1): 92-100.
43. Eghbali-Fatourechi G, Khosla S, Sanyal A, Boyle WJ, Lacey DL, Riggs BL,. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest. 2003; 111 (8): 1221-30. (Pubitemid 36519939)
44. Ammann P, Rizzoli R, Bonjour JP, Bourrin S, Meyer JM, Vassalli P, Garcia I,. Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency. J Clin Invest. 1997; 99: 1699-703. (Pubitemid 27163821)
45. Kimble R, Bain S, Pacifici R,. The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice. J Bone Miner Res. 1997; 12: 935-41. (Pubitemid 27225004)
46. Cenci S, Toraldo G, Weitzmann MN, Roggia C, Gao Y, Qian WP, Sierra O, Pacifici R,. Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator. Proc Natl Acad Sci U S A. 2003; 100 (18): 10405-10. (Pubitemid 37071891)
47. Grassi F, Pacifici R,. Ovariectomy increases the formation of T cell niches at the resorption surfaces. J Bone Miner Res. 2005; 20 (Suppl 1):Abs.
48. Haynes BF, Sempowski GD, Wells AF, Hale LP,. The human thymus during aging. Immunol Res. 2000; 22 (2-3): 253-61. (Pubitemid 32382238)
49. Douek DC, Koup RA,. Evidence for thymic function in the elderly. Vaccine. 2000; 18 (16): 1638-41. (Pubitemid 30109521)
50. Jamieson BD, Douek DC, Killian S, Hultin LE, Scripture-Adams DD, Giorgi JV, Marelli D, Koup RA, Zack JA,. Generation of functional thymocytes in the human adult. Immunity. 1999; 10 (5): 569-75. (Pubitemid 29262659)
51. Steinmann GG, Klaus B, Muller-Hermelink HK,. The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study. Scand J Immunol. 1985; 22 (5): 563-75. (Pubitemid 16174333)
52. Hakim FT, Memon SA, Cepeda R, Jones EC, Chow CK, Kasten-Sportes C, Odom J, Vance BA, Christensen BL, Mackall CL, Gress RE,. Age-dependent incidence, time course, and consequences of thymic renewal in adults. J Clin Invest. 2005; 115 (4): 930-9. (Pubitemid 40489397)
53. Mackall CL, Fry TJ, Bare C, Morgan P, Galbraith A, Gress RE,. IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation. Blood. 2001; 97 (5): 1491-7. (Pubitemid 32183777)
54. Leposavic G, Perisic M,. Age-associated remodeling of thymopoiesis: role for gonadal hormones and catecholamines. Neuroimmunomodulation. 2008; 15 (4-6): 290-322.
55. Leposavic G, Perisic M, Kosec D, Arsenovic-Ranin N, Radojevic K, Stojic-Vukanic Z, Pilipovic I,. Neonatal testosterone imprinting affects thymus development and leads to phenotypic rejuvenation and masculinization of the peripheral blood T-cell compartment in adult female rats. Brain Behav Immun. 2009; 23 (2): 294-304.
56. Utsuyama M, Hirokawa K,. Hypertrophy of the thymus and restoration of immune functions in mice and rats by gonadectomy. Mech Ageing Dev. 1989; 47 (3): 175-85. (Pubitemid 19084871)
57. Okasha SA, Ryu S, Do Y, McKallip RJ, Nagarkatti M, Nagarkatti PS,. Evidence for estradiol-induced apoptosis and dysregulated T cell maturation in the thymus. Toxicology. 2001; 163 (1): 49-62. (Pubitemid 32497165)
58. Roden AC, Moser MT, Tri SD, Mercader M, Kuntz SM, Dong H, Hurwitz AA, McKean DJ, Celis E, Leibovich BC, Allison JP, Kwon ED,. Augmentation of T cell levels and responses induced by androgen deprivation. J Immunol. 2004; 173 (10): 6098-108. (Pubitemid 39487766)
59. Sutherland JS, Goldberg GL, Hammett MV, Uldrich AP, Berzins SP, Heng TS, Blazar BR, Millar JL, Malin MA, Chidgey AP, Boyd RL,. Activation of thymic regeneration in mice and humans following androgen blockade. J Immunol. 2005; 175 (4): 2741-53. (Pubitemid 41113891)
60. Perisić M, Arsenović-Ranin N, Pilipović I, Kosec D, Pesić V, Radojević K, Leposavić G,. Role of ovarian hormones in age-associated thymic involution revisited. Immunobiology. 215 (4): 275-93.
61. Ryan MR, Shepherd R, Leavey JK, Gao Y, Grassi F, Schnell FJ, Qian WP, Kersh GJ, Weitzmann MN, Pacifici R,. An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency. Proc Natl Acad Sci U S A. 2005; 102 (46): 16735-40. (Pubitemid 41688846)
62. Hreshchyshyn MM, Hopkins A, Zylstra S, Anbar M,. Effects of natural menopause, hysterectomy, and oophorectomy on lumbar spine and femoral neck bone densities. Obstet Gynecol. 1988; 72 (4): 631-8.
63. Riggs BL, Khosla S, Melton LJ 3rd., Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev. 2002; 23 (3): 279-302. (Pubitemid 34651948)
64. Lean JM, Davies JT, Fuller K, Jagger CJ, Kirstein B, Partington GA, Urry ZL, Chambers TJ,. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest. 2003; 112 (6): 915-23. (Pubitemid 38063749)
65. Muthusami S, Ramachandran I, Muthusamy B, Vasudevan G, Prabhu V, Subramaniam V, Jagadeesan A, Narasimhan S,. Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats. Clin Chim Acta. 2005; 360 (1-2): 81-6. (Pubitemid 41225396)
66. Basu S, Michaelsson K, Olofsson H, Johansson S, Melhus H,. Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun. 2001; 288 (1): 275-9. (Pubitemid 32999758)
67. Maggio D, Barabani M, Pierandrei M, Polidori MC, Catani M, Mecocci P, Senin U, Pacifici R, Cherubini A,. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab. 2003; 88 (4): 1523-7. (Pubitemid 36623364)
68. Finkel T,. Oxidant signals and oxidative stress. Curr Opin Cell Biol. 2003; 15 (2): 247-54. (Pubitemid 36332201)
69. Ozaki M, Suzuki S, Irani K,. Redox factor-1/APE suppresses oxidative stress by inhibiting the rac1 GTPase. FASEB J. 2002; 16 (8): 889-90.
70. Almeida M, Han L, Martin-Millan M, Plotkin LI, Stewart SA, Roberson PK, Kousteni S, O'Brien CA, Bellido T, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC,. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem. 2007; 282 (37): 27285-97. (Pubitemid 47501960)
71. Almeida M, Martin-Millan M, Ambrogini E, Bradsher R 3rd, Han L, Chen XD, Roberson PK, Weinstein RS, O'Brien CA, Jilka RL, Manolagas SC,. Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha. J Bone Miner Res. 2010; 25 (4): 769-81.
72. Mizuashi M, Ohtani T, Nakagawa S, Aiba S,. Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells. J Invest Dermatol. 2005; 124 (3): 579-86. (Pubitemid 40381581)
73. Rutault K, Alderman C, Chain BM, Katz DR,. Reactive oxygen species activate human peripheral blood dendritic cells. Free Radic Biol Med. 1999; 26 (1-2): 232-8.
74. Maemura K, Zheng Q, Wada T, Ozaki M, Takao S, Aikou T, Bulkley GB, Klein AS, Sun Z,. Reactive oxygen species are essential mediators in antigen presentation by Kupffer cells. Immunol Cell Biol. 2005; 83 (4): 336-43. (Pubitemid 41044610)
75. Vosters O, Neve J, De Wit D, Willems F, Goldman M, Verhasselt V,. Dendritic cells exposed to nacystelyn are refractory to maturation and promote the emergence of alloreactive regulatory t cells. Transplantation. 2003; 75 (3): 383-9. (Pubitemid 36222967)
76. Verhasselt V, Vanden Berghe W, Vanderheyde N, Willems F, Haegeman G, Goldman M,. N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-kappaB inhibition. J Immunol. 1999; 162 (5): 2569-74. (Pubitemid 29309275)
77. Jagger CJ, Lean JM, Davies JT, Chambers TJ,. Tumor necrosis factor-alpha mediates osteopenia caused by depletion of antioxidants. Endocrinology. 2005; 146 (1): 113-8. (Pubitemid 40051730)
78. Yang NN, Venugopalan M, Hardikar S, Glasebrook A,. Identification of an estrogen response element activated by metabolites of 17b-estradiol and raloxifene. Science. 1996; 273: 1222-5. (Pubitemid 26293211)
79. Boss JM, Jensen PE,. Transcriptional regulation of the MHC class II antigen presentation pathway. Curr Opin Immunol. 2003; 15 (1): 105-11. (Pubitemid 35454200)
80. Takayanagi H, Ogasawara K, Hida S, Chiba T, Murata S, Sato K, Takaoka A, Yokochi T, Oda H, Tanaka K, Nakamura K, Taniguchi T,. T-cell-mediated regulation of osteoclastogenesis by signalling cross- talk between RANKL and IFN-gamma. Nature. 2000; 408 (6812): 600-5.
81. Vermeire K, Heremans H, Vandeputte M, Huang S, Billiau A, Matthys P,. Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice. J Immunol. 1997; 158 (11): 5507-13. (Pubitemid 127681260)
82. Sato K, Satoh T, Shizume K, Yamakawa Y, Ono Y, Demura H, Akatsu T, Takahashi N, Suda T,. Prolonged decrease of serum calcium concentration by murine gamma-interferon in hypercalcemic, human tumor (EC-GI)-bearing nude mice. Cancer Res. 1992; 52 (2): 444-9.
83. Tohkin M, Kakudo S, Kasai H, Arita H,. Comparative study of inhibitory effects by murine interferon gamma and a new bisphosphonate (alendronate) in hypercalcemic, nude mice bearing human tumor (LJC-1-JCK). Cancer Immunol Immunother. 1994; 39 (3): 155-60. (Pubitemid 24298388)
84. Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, Eguchi T, Masuyama R, Yoshida N,. IFN-gamma directly inhibits TNF-alpha-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions. Immunol Lett. 2011; 137 (1-2): 53-61.
85. Ji JD, Park-Min KH, Shen Z, Fajardo RJ, Goldring SR, McHugh KP, Ivashkiv LB,. Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors. J Immunol. 2009; 183 (11): 7223-33.
86. Key LL Jr, Rodriguiz RM, Willi SM, Wright NM, Hatcher HC, Eyre DR, Cure JK, Griffin PP, Ries WL,. Long-term treatment of osteopetrosis with recombinant human interferon gamma. N Engl J Med. 1995; 332 (24): 1594-9.
87. Rodriguiz RM, Key LL Jr, Ries WL,. Combination macrophage-colony stimulating factor and interferon-gamma administration ameliorates the osteopetrotic condition in microphthalmic (mi/mi) mice. Pediatr Res. 1993; 33 (4 Pt 1): 384-9. (Pubitemid 23095771)
88. Baker PJ, Dixon M, Evans RT, Dufour L, Johnson E, Roopenian DC,. CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immun. 1999; 67 (6): 2804-9. (Pubitemid 29244693)
89. Arnoldi J, Gerdes J, Flad HD,. Immunohistologic assessment of cytokine production of infiltrating cells in various forms of leprosy. Am J Pathol. 1990; 137 (4): 749-53. (Pubitemid 20337789)
90. Cannon GW, Pincus SH, Emkey RD, Denes A, Cohen SA, Wolfe F, Saway PA, Jaffer AM, Weaver AL, Cogen L, et al. Double-blind trial of recombinant gamma-interferon versus placebo in the treatment of rheumatoid arthritis. Arthritis Rheum. 1989; 32 (8): 964-73. (Pubitemid 19218375)
91. Mann GN, Jacobs TW, Buchinsky FJ, Armstrong EC, Li M, Ke HZ, Ma YF, Jee WS, Epstein S,. Interferon-gamma causes loss of bone volume in vivo and fails to ameliorate cyclosporin A-induced osteopenia. Endocrinology. 1994; 135: 1077-83.
92. Duque G, Huang DC, Dion N, Macoritto M, Rivas D, Li W, Yang XF, Li J, Lian J, Marino FT, Barralet J, Lascau V, Deschenes C, Ste-Marie LG, Kremer R,. Interferon-gamma plays a role in bone formation in vivo and rescues osteoporosis in ovariectomized mice. J Bone Miner Res. 2011; 26 (7): 1472-83.
93. Takayanagi H, Kim S, Taniguchi T,. Signaling crosstalk between RANKL and interferons in osteoclast differentiation. Arthritis Res. 2002; 4 (Suppl 3): S227-32.
94. Duque G, Huang DC, Macoritto M, Rivas D, Yang XF, Ste-Marie LG, Kremer R,. Autocrine regulation of interferon gamma in mesenchymal stem cells plays a role in early osteoblastogenesis. Stem Cells. 2009; 27 (3): 550-8.
95. Miyaura C, Onoe Y, Inada M, Maki K, Ikuta K, Ito M, Suda T,. Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency. Proc Natl Acad Sci U S A. 1997; 19: 9360-5. (Pubitemid 27357834)
96. Weitzmann MN, Roggia C, Toraldo G, Weitzmann L, Pacifici R,. Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest. 2002; 110 (11): 1643-50. (Pubitemid 35424242)
97. Huang M, Sharma S, Zhu LX, Keane MP, Luo J, Zhang L, Burdick MD, Lin YQ, Dohadwala M, Gardner B, Batra RK, Strieter RM, Dubinett SM,. IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis. J Clin Invest. 2002; 109 (7): 931-7.
98. Dubinett SM, Huang M, Dhanani S, Economou JS, Wang J, Lee P, Sharma S, Dougherty GJ, McBride WH,. Down-regulation of murine fibrosarcoma transforming growth factor-beta 1 expression by interleukin 7. J Natl Cancer Inst. 1995; 87 (8): 593-7.
99. Grewal IS, Flavell RA,. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol. 1998; 16: 111-35. (Pubitemid 28183361)
100. Quezada SA, Jarvinen LZ, Lind EF, Noelle RJ,. CD40/CD154 interactions at the interface of tolerance and immunity. Annu Rev Immunol. 2004; 22: 307-28. (Pubitemid 38680425)
101. Andre P, Prasad KS, Denis CV, He M, Papalia JM, Hynes RO, Phillips DR, Wagner DD,. CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism. Nat Med. 2002; 8 (3): 247-52. (Pubitemid 34250102)
102. Leveille C, Bouillon M, Guo W, Bolduc J, Sharif-Askari E, El-Fakhry Y, Reyes-Moreno C, Lapointe R, Merhi Y, Wilkins JA, Mourad W,. CD40 ligand binds to alpha5beta1 integrin and triggers cell signaling. J Biol Chem. 2007; 282 (8): 5143-51. (Pubitemid 47093769)
103. Ahuja SS, Zhao S, Bellido T, Plotkin LI, Jimenez F, Bonewald LF,. CD40 ligand blocks apoptosis induced by tumor necrosis factor alpha, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4. Endocrinology. 2003; 144 (5): 1761-9. (Pubitemid 36543313)
104. Li Y, Toraldo G, Li A, Yang X, Zhang H, Qian WP, Weitzmann MN,. B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood. 2007; 109 (9): 3839-48. (Pubitemid 46641735)
105. Lopez-Granados E, Temmerman ST, Wu L, Reynolds JC, Follmann D, Liu S, Nelson DL, Rauch F, Jain A,. Osteopenia in X-linked hyper-IgM syndrome reveals a regulatory role for CD40 ligand in osteoclastogenesis. Proc Natl Acad Sci U S A. 2007; 104 (12): 5056-61. (Pubitemid 47186175)
106. Gao Y, Wu X, Terauchi M, Li JY, Grassi F, Galley S, Yang X, Weitzmann MN, Pacifici R,. T cells potentiate PTH-induced cortical bone loss through CD40L signaling. Cell Metab. 2008; 8 (2): 132-45.
107. Abdallah BM, Ding M, Jensen CH, Ditzel N, Flyvbjerg A, Jensen TG, Dagnaes-Hansen F, Gasser JA, Kassem M,. Dlk1/FA1 is a novel endocrine regulator of bone and fat mass and its serum level is modulated by growth hormone. Endocrinology. 2007; 148 (7): 3111-21. (Pubitemid 46996977)
108. Abdallah BM, Boissy P, Tan Q, Dahlgaard J, Traustadottir GA, Kupisiewicz K, Laborda J, Delaisse JM, Kassem M,. dlk1/FA1 regulates the function of human bone marrow mesenchymal stem cells by modulating gene expression of pro-inflammatory cytokines and immune response-related factors. J Biol Chem. 2007; 282 (10): 7339-51. (Pubitemid 47093687)
109. Abdallah BM, Ditzel N, Mahmood A, Isa A, Traustadottir GA, Schilling AF, Ruiz-Hidalgo MJ, Laborda J, Amling M, Kassem M,. DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice. J Bone Miner Res. 2011; 26 (7): 1457-71.
110. Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM,. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 2000; 103 (1): 41-50.
111. Mulac-Jericevic B, Lydon JP, DeMayo FJ, Conneely OM,. Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc Natl Acad Sci U S A. 2003; 100 (17): 9744-9. (Pubitemid 37087012)
112. Schramek D, Sigl V, Penninger JM,. RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis. Trends Endocrinol Metab. 2011; 22 (5): 188-94.
113. Aluvihare VR, Kallikourdis M, Betz AG,. Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol. 2004; 5 (3): 266-71. (Pubitemid 38332123)
114. Lonergan M, Aponso D, Marvin KW, Helliwell RJ, Sato TA, Mitchell MD, Chaiwaropongsa T, Romero R, Keelan JA,. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), TRAIL receptors, and the soluble receptor osteoprotegerin in human gestational membranes and amniotic fluid during pregnancy and labor at term and preterm. J Clin Endocrinol Metab. 2003; 88 (8): 3835-44. (Pubitemid 37034536)