Daidzein prevents the increase in CD4+CD28null T cells and B lymphopoesis in ovariectomized mice: A key mechanism for anti-osteoclastogenic effect

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Tyagi, Abdul Malik ^a   Srivastava, Kamini ^a   Sharan, Kunal ^a   Yadav, Dinesh ^a   Maurya, Rakesh ^a   Singh, Divya ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; DAIDZEIN; ESTRADIOL; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATASE; TARTARATE RESISTANT ACID PHOSPHATASE; UNCLASSIFIED DRUG; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; ISOFLAVONE DERIVATIVE; NUCLEOLIN; PHOSPHOPROTEIN; REACTIVE OXYGEN METABOLITE; RNA BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BONE MARROW CELL; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; LYMPHOPOIESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; PROTEIN EXPRESSION; REGULATORY MECHANISM; SPLEEN CELL; T LYMPHOCYTE; ANIMAL; B LYMPHOCYTE; BLOOD; BONE DEVELOPMENT; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; COCULTURE; CYTOLOGY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; FEMUR; GENETICS; LYMPHOCYTE COUNT; METABOLISM; ORGAN SIZE; OSTEOCLAST; PATHOLOGY; RADIOGRAPHY; SPLEEN; THYMUS;

ANIMALIA; GLYCINE MAX; MUS; PISUM SATIVUM;

ANIMALS; ANTIGENS, CD28; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FEMALE; FEMUR; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; ISOFLAVONES; LYMPHOCYTE COUNT; LYMPHOPOIESIS; MICE; ORGAN SIZE; OSTEOCLASTS; OSTEOGENESIS; OVARIECTOMY; PHOSPHOPROTEINS; REACTIVE OXYGEN SPECIES; RNA-BINDING PROTEINS; SPLEEN; THYMUS GLAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79959435355     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021216     Document Type: Article

References (51)

1. Roggia C, Gao Y, Cenci S, Weitzmann MN, Toraldo G, et al. (2001) Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo. Proc Natl Acad Sci U S A 98: 13960-13965.
2. Weitzmann MN, Pacifici R, (2005) The role of T lymphocytes in bone metabolism. Immunol Rev 208: 154-168.
3. Pacifici R, (2007) T cells and post menopausal osteoporosis in murine models. Arthritis Res Ther 9: 102.
4. D'Amelio P, Grimaldi A, Di Bella S, Brianza SZ, Cristofaro MA, et al. (2008) Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis. Bone 43: 92-100.
5. Vallejo AN, Weyand CM, Goronzy JJ, (2004) T cell senescense: a culprit of immune abnormalities in chronic inflammation and persistent infection. Trends in Molecular Medicine 10: 119-124.
6. Effros RB, (1997) Loss of CD28 expression on T lymphocytes: a marker of replicative senescence. Dev Comp Immunol 21: 471-478.
7. Vallejo AN, Brandes JC, Weyand CM, Goronzy JJ, (1999) Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence. J Immunol 162: 6572-6579.
8. Vallejo AN, Bryl E, Klarskov K, Naylor S, Weyand CM, et al. (2002) Molecular basis for the loss of CD28 expression in senescent T cells. J Biol Chem 277: 46940-46949.
9. Effros RB, (1998) Replicative senescence: impact on T cell immunity in the elderly. Aging (Milano) 10: 152.
10. Effros RB, Boucher N, Porter V, Zhu X, Spaulding C, et al. (1994) Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol 29: 601-609.
11. Tyagi AM, Srivastava K, Kureel J, Kumar A, Raghuvanshi A, et al. (2011) Premature T Cell Senescense in Ovx Mice is Inhibited by Repletion of Estrogen and Medicarpin: A Possible Mechanism for Alleviating Bone Loss. Osteoporos Int In Press.
12. Miyaura C, Onoe Y, Inada M, Maki K, Ikuta K, et al. (1997) Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency. Proc Natl Acad Sci U S A 94: 9360-9365.
13. Li Y, Li A, Yang X, Weitzmann MN, (2007) Ovariectomy-induced bone loss occurs independently of B cells. J Cell Biochem 100: 1370-1375.
14. Li R, Gilliland FD, Baumgartner K, Samet J, (2002) Hormone replacement therapy and breast carcinoma risk in Hispanic and non-Hispanic women. Cancer 95: 960-968.
15. Hertrampf T, Gruca MJ, Seibel J, Laudenbach U, Fritzemeier KH, et al. (2007) The bone-protective effect of the phytoestrogen genistein is mediated via ER alpha-dependent mechanisms and strongly enhanced by physical activity. Bone 40: 1529-1535.
16. Bitto A, Polito F, Burnett B, Levy R, Di Stefano V, et al. (2009) Protective effect of genistein aglycone on the development of osteonecrosis of the femoral head and secondary osteoporosis induced by methylprednisolone in rats. J Endocrinol 201: 321-328.
17. Setchell KD, Lydeking-Olsen E, (2003) Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Am J Clin Nutr 78: 593S-609S.
18. Somekawa Y, Chiguchi M, Ishibashi T, Aso T, (2001) Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet Gynecol 97: 109-115.
19. Mei J, Yeung SS, Kung AW, (2001) High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women. J Clin Endocrinol Metab 86: 5217-5221.
20. Kritz-Silverstein D, Goodman-Gruen DL, (2002) Usual dietary isoflavone intake, bone mineral density, and bone metabolism in postmenopausal women. J Womens Health Gend Based Med 11: 69-78.
21. Morito K, Aomori T, Hirose T, Kinjo J, Hasegawa J, et al. (2002) Interaction of phytoestrogens with estrogen receptors alpha and beta (II). Biol Pharm Bull 25: 48-52.
22. Ishimi Y, Yoshida M, Wakimoto S, Wu J, Chiba H, et al. (2002) Genistein, a soybean isoflavone, affects bone marrow lymphopoiesis and prevents bone loss in castrated male mice. Bone 31: 180-185.
23. Sakai T, Kogiso M, (2008) Soy isoflavones and immunity. J Med Invest 55: 167-173.
24. Rapaport FT, Terashima T, Tsukuda K, Kono K, Takayama T, et al. (1997) Suppression of lectin, alloantigen, and xenoantigen-induced T-cell proliferation by Genistein. Transplant Proc 29: 1261-1264.
25. Ishimi Y, Miyaura C, Ohmura M, Onoe Y, Sato T, et al. (1999) Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency. Endocrinology 140: 1893-1900.
26. Erlandsson MC, Gomori E, Taube M, Carlsten H, (2000) Effects of raloxifene, a selective estrogen receptor modulator, on thymus, T cell reactivity, and inflammation in mice. Cell Immunol 205: 103-109.
27. Kalu DN, Salerno E, Liu CC, Ferarro F, Arjmandi BN, et al. (1993) Ovariectomy-induced bone loss and the hematopoietic system. Bone Miner 23: 145-161.
28. Grassi F, Tell G, Robbie-Ryan M, Gao Y, Terauchi M, et al. (2007) Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Proc Natl Acad Sci U S A 104: 15087-15092.
29. Kawai T, Matsuyama T, Hosokawa Y, Makihira S, Seki M, et al. (2006) B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease. Am J Pathol 169: 987-998.
30. Horowitz MC, Bothwell AL, Hesslein DG, Pflugh DL, Schatz DG, (2005) B cells and osteoblast and osteoclast development. Immunol Rev 208: 141-153.
31. Puel C, Mathey J, Agalias A, Kati-Coulibaly S, Mardon J, et al. (2006) Dose-response study of effect of oleuropein, an olive oil polyphenol, in an ovariectomy/inflammation experimental model of bone loss in the rat. Clin Nutr 25: 859-868.
32. Yellayi S, Naaz A, Szewczykowski MA, Sato T, Woods JA, et al. (2002) The phytoestrogen genistein induces thymic and immune changes: a human health concern? Proc Natl Acad Sci U S A 99: 7616-7621.
33. Sakai T, Furoku S, Nakamoto M, Shuto E, Hosaka T, et al. (2010) The soy isoflavone equol enhances antigen-specific IgE production in ovalbumin-immunized BALB/c mice. J Nutr Sci Vitaminol (Tokyo) 56: 72-76.
34. Lean JM, Davies JT, Fuller K, Jagger CJ, Kirstein B, et al. (2003) A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest 112: 915-923.
35. Sun D, Krishnan A, Zaman K, Lawrence R, Bhattacharya A, et al. (2003) Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice. J Bone Miner Res 18: 1206-1216.
36. Rosen CJ, Usiskin K, Owens M, Barlascini CO, Belsky M, et al. (1990) T lymphocyte surface antigen markers in osteoporosis. J Bone Miner Res 5: 851-855.
37. Imanishi T, Hano T, Nishio I, (2005) Estrogen reduces angiotensin II-induced acceleration of senescence in endothelial progenitor cells. Hypertens Res 28: 263-271.
38. Bryl E, Vallejo AN, Weyand CM, Goronzy JJ, (2001) Down-regulation of CD28 expression by TNF-alpha. J Immunol 167: 3231-3238.
39. Masuzawa T, Miyaura C, Onoe Y, Kusano K, Ohta H, et al. (1994) Estrogen deficiency stimulates B lymphopoiesis in mouse bone marrow. J Clin Invest 94: 1090-1097.
40. Aubin JE, Bonnelye E, (2000) Osteoprotegerin and its ligand: a new paradigm for regulation of osteoclastogenesis and bone resorption. Osteoporos Int 11: 905-913.
41. Cenci S, Toraldo G, Weitzmann MN, Roggia C, Gao Y, et al. (2003) Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator. Proc Natl Acad Sci U S A 100: 10405-10410.
42. Baker PJ, Dixon M, Evans RT, Dufour L, Johnson E, et al. (1999) CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immun 67: 2804-2809.
43. Tarjanyi O, Boldizsar F, Nemeth P, Mikecz K, Glant TT, (2009) Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis. Immun Ageing 6: 8.
44. Kozlowska E, Biernacka M, Ciechomska M, Drela N, (2007) Age-related changes in the occurrence and characteristics of thymic CD4(+) CD25(+) T cells in mice. Immunology 122: 445-453.
45. Miyamoto M, Matsushita Y, Kiyokawa A, Fukuda C, Iijima Y, et al. (1998) Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism. Planta Med 64: 516-519.
46. Pandey R, Gautam AK, Bhargavan B, Trivedi R, Swarnkar G, et al. Total extract and standardized fraction from the stem bark of Butea monosperma have osteoprotective action: evidence for the nonestrogenic osteogenic effect of the standardized fraction. Menopause 17: 602-610.
47. Picherit C, Coxam V, Bennetau-Pelissero C, Kati-Coulibaly S, Davicco MJ, et al. (2000) Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats. J Nutr 130: 1675-1681.
48. Bianchi F, Bernardini N, Marchetti P, Navalesi R, Giannarelli R, et al. (1993) In vitro morpho-functional analysis of pancreatic islets isolated from the domestic chicken. Tissue Cell 25: 817-824.
49. Marchetti P, Giannarelli R, Villani G, Andreozzi M, Cruschelli L, et al. (1994) Collagenase distension, two-step sequential filtration, and histopaque gradient purification for consistent isolation of pure pancreatic islets from the market-age (6-month-old) pig. Transplantation 57: 1532-1535.
50. Bryl E, Vallejo AN, Matteson EL, Witkowski JM, Weyand CM, et al. (2005) Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis. Arthritis Rheum 52: 2996-3003.
51. Banfi G, Iorio EL, Corsi MM, (2008) Oxidative stress, free radicals and bone remodeling. Clin Chem Lab Med 46: 1550-1555.