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Volumn 101, Issue 9, 1998, Pages 1942-1950

Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow evidence for autonomy from factors released during bone resorption

Author keywords

Bone remodeling; Estrogen deficiency; Osteoblast formation; Osteoclast formation; Postmenopausal osteoporosis

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE REMODELING; ESTROGEN METABOLISM; FEMALE; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOLYSIS; OVARIECTOMY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL;

EID: 0032080656     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1039     Document Type: Article
Times cited : (176)

References (46)
  • 2
    • 0029837583 scopus 로고    scopus 로고
    • Advances in bone biology: The osteoclast
    • Roodman, G.D. 1996. Advances in bone biology: the osteoclast. Endocr. Rev. 17:308-332.
    • (1996) Endocr. Rev. , vol.17 , pp. 308-332
    • Roodman, G.D.1
  • 3
    • 0025845372 scopus 로고
    • Initiation and progression of mineralization of bone nodules formed in vitro: The role of alkaline phosphatase and organic phosphate
    • Bellows, C.G., J.E. Aubin, and J.N.M. Heersche. 1991. Initiation and progression of mineralization of bone nodules formed in vitro: the role of alkaline phosphatase and organic phosphate. Bone Miner. 14:27-40.
    • (1991) Bone Miner. , vol.14 , pp. 27-40
    • Bellows, C.G.1    Aubin, J.E.2    Heersche, J.N.M.3
  • 4
    • 0028301173 scopus 로고
    • Characterization and purification of osteogenic cells from murine bone marrow by two-color cell sorting using anti-Sca-1 monoclonal antibody and wheat germ agglutinin
    • Van Vlasselaer, P., N. Falla, H. Snoeck, and E. Mathieu. 1994. Characterization and purification of osteogenic cells from murine bone marrow by two-color cell sorting using anti-Sca-1 monoclonal antibody and wheat germ agglutinin. Blood. 84:753-763.
    • (1994) Blood , vol.84 , pp. 753-763
    • Van Vlasselaer, P.1    Falla, N.2    Snoeck, H.3    Mathieu, E.4
  • 5
    • 85003152202 scopus 로고
    • Modulation of osteoclast differentiation
    • Suda, T., N. Takahashi, and T.J. Martin. 1992. Modulation of osteoclast differentiation. Endocr. Rev. 13:66-80.
    • (1992) Endocr. Rev. , vol.13 , pp. 66-80
    • Suda, T.1    Takahashi, N.2    Martin, T.J.3
  • 6
    • 0020509916 scopus 로고
    • Relationships between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis: Implications for the microanatomic and cellular mechanism of bone loss
    • Parfitt, A.M., C.H.E. Mathews, A.R. Villanueva, M. Kleerekoper, B. Frame, and D.S. Rao. 1983. Relationships between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis: implications for the microanatomic and cellular mechanism of bone loss. J. Clin. Invest. 72:1396-1409.
    • (1983) J. Clin. Invest. , vol.72 , pp. 1396-1409
    • Parfitt, A.M.1    Mathews, C.H.E.2    Villanueva, A.R.3    Kleerekoper, M.4    Frame, B.5    Rao, D.S.6
  • 7
    • 0025100436 scopus 로고
    • Cancellous bone remodeling in type I (postmenopausal) osteoporosis: Quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels
    • Eriksen, E.F., S.F. Hodgson, R. Eastell, S.L. Cedel, W.M. O'Fallon, and B.L. Riggs. 1990. Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels. J. Bone Miner. Res. 5:311-319.
    • (1990) J. Bone Miner. Res. , vol.5 , pp. 311-319
    • Eriksen, E.F.1    Hodgson, S.F.2    Eastell, R.3    Cedel, S.L.4    O'Fallon, W.M.5    Riggs, B.L.6
  • 9
    • 0027139913 scopus 로고
    • The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates
    • Balena, R., B.C. Toolan, M. Shea, A. Markatos, E.R. Myers, S.C. Lee, E.E. Opas, J.G. Seedor, H. Klein, D. Frankenfield, et al. 1993. The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. J. Clin. Invest. 92:2577-2586.
    • (1993) J. Clin. Invest. , vol.92 , pp. 2577-2586
    • Balena, R.1    Toolan, B.C.2    Shea, M.3    Markatos, A.4    Myers, E.R.5    Lee, S.C.6    Opas, E.E.7    Seedor, J.G.8    Klein, H.9    Frankenfield, D.10
  • 10
    • 0026068145 scopus 로고
    • The ovariectomized rat model of postmenopausal bone loss
    • Kalu, D.N. 1991. The ovariectomized rat model of postmenopausal bone loss. Bone Miner. 15:175-192.
    • (1991) Bone Miner. , vol.15 , pp. 175-192
    • Kalu, D.N.1
  • 13
    • 0026516415 scopus 로고
    • 17β-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in-vitro: A potential mechanism for the antiosteoporotic effect of estrogens
    • Girasole, G., R.L. Jilka, G. Passeri, S. Boswell, G. Boder, D.C. Williams, and S.C. Manolagas. 1992. 17β-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in-vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J. Clin. Invest. 89:883-891.
    • (1992) J. Clin. Invest. , vol.89 , pp. 883-891
    • Girasole, G.1    Jilka, R.L.2    Passeri, G.3    Boswell, S.4    Boder, G.5    Williams, D.C.6    Manolagas, S.C.7
  • 14
    • 0028180435 scopus 로고
    • 17β-estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism
    • Pottratz, S.T., T. Bellido, H. Mocharla, D. Crabb, and S.C. Manolagas. 1994 17β-estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J. Clin. Invest. 93:944-950.
    • (1994) J. Clin. Invest. , vol.93 , pp. 944-950
    • Pottratz, S.T.1    Bellido, T.2    Mocharla, H.3    Crabb, D.4    Manolagas, S.C.5
  • 15
    • 0028222533 scopus 로고
    • Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor
    • Ray, A., K.E. Prefontaine, and P. Ray. 1994. Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor. J. biol. Chem. 269:12940-12946.
    • (1994) J. Biol. Chem. , vol.269 , pp. 12940-12946
    • Ray, A.1    Prefontaine, K.E.2    Ray, P.3
  • 16
    • 0029147741 scopus 로고
    • Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta
    • Stein, B., and M.X. Yang. 1995. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol. Cell Biol. 15:4971-4979.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 4971-4979
    • Stein, B.1    Yang, M.X.2
  • 17
    • 0030020568 scopus 로고    scopus 로고
    • Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors
    • Kassem, M., S.A. Harris, T.C. Spelsberg, and B.L. Riggs. 1996. Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors. J. Bone Miner. Res. 11:193-199.
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 193-199
    • Kassem, M.1    Harris, S.A.2    Spelsberg, T.C.3    Riggs, B.L.4
  • 18
    • 0030873289 scopus 로고    scopus 로고
    • Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-kappaB site
    • Galien, R., and T. Garcia. 1997. Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-kappaB site. Nucleic Acids Res. 25:2424-2429.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2424-2429
    • Galien, R.1    Garcia, T.2
  • 20
    • 0027716520 scopus 로고
    • Biochemical markers of bone turnover
    • Delmas, P.D. 1993. Biochemical markers of bone turnover. J. Bone Miner. Res. 8:S549-S554.
    • (1993) J. Bone Miner. Res. , vol.8
    • Delmas, P.D.1
  • 22
    • 0029928698 scopus 로고    scopus 로고
    • Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence
    • Jilka, R.L., R.S. Weinstein, K. Takahashi, A.M. Parfitt, and S.C. Manolagas. 1996. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. J. Clin. Invest. 97:1732-1740.
    • (1996) J. Clin. Invest. , vol.97 , pp. 1732-1740
    • Jilka, R.L.1    Weinstein, R.S.2    Takahashi, K.3    Parfitt, A.M.4    Manolagas, S.C.5
  • 24
    • 0030802506 scopus 로고    scopus 로고
    • The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage
    • Weinstein, R.S., R.L. Jilka, A.M. Parfitt, and S.C. Manolagas. 1997. The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage. Endocrinology. 138: 4013-4021.
    • (1997) Endocrinology , vol.138 , pp. 4013-4021
    • Weinstein, R.S.1    Jilka, R.L.2    Parfitt, A.M.3    Manolagas, S.C.4
  • 25
    • 0002203349 scopus 로고    scopus 로고
    • The stem cell of the osteoblast
    • J.P. Bilezikian, L.G. Raisz, and G.A. Rodan, editors. Academic Press, San Diego. CA
    • Triffitt, J.T. 1996. The stem cell of the osteoblast. In Principles of Bone Biology. J.P. Bilezikian, L.G. Raisz, and G.A. Rodan, editors. Academic Press, San Diego. CA. 39-50.
    • (1996) Principles of Bone Biology , pp. 39-50
    • Triffitt, J.T.1
  • 26
    • 0024797888 scopus 로고
    • Long-term effects of ovariectomy and aging on the rat skeleton
    • Wronski, T.J., L.M. Dann, K.S. Scott, and M. Cintrön. 1989. Long-term effects of ovariectomy and aging on the rat skeleton. Calcif. Tissue Int. 45:360-366.
    • (1989) Calcif. Tissue Int. , vol.45 , pp. 360-366
    • Wronski, T.J.1    Dann, L.M.2    Scott, K.S.3    Cintrön, M.4
  • 27
    • 0029930828 scopus 로고    scopus 로고
    • Comparative study of skeletal response to estrogen depletion at red and yellow marrow sites in rats
    • Li, M., Y. Shen, H. Qi, and T.J. Wronski. 1996. Comparative study of skeletal response to estrogen depletion at red and yellow marrow sites in rats. Anat. Rec. 245:472-480.
    • (1996) Anat. Rec. , vol.245 , pp. 472-480
    • Li, M.1    Shen, Y.2    Qi, H.3    Wronski, T.J.4
  • 29
    • 0029095504 scopus 로고
    • In vitro and ex vivo evidence that estrogens suppress increased bone resorption induced by ovariectomy or PTH stimulation through an effect on osteoclastogenesis
    • Most, W., L. Schot, A. Ederveen, L. Van der Wee-Pals, S. Papapoulos, and C. Löwik. 1995. In vitro and ex vivo evidence that estrogens suppress increased bone resorption induced by ovariectomy or PTH stimulation through an effect on osteoclastogenesis. J. Bone Miner. Res. 10:1523-1530.
    • (1995) J. Bone Miner. Res. , vol.10 , pp. 1523-1530
    • Most, W.1    Schot, L.2    Ederveen, A.3    Van Der Wee-Pals, L.4    Papapoulos, S.5    Löwik, C.6
  • 30
    • 0029824815 scopus 로고    scopus 로고
    • Effect of age and ovariectomy on fibroblastic colony-forming unit numbers in rat bone marrow
    • Scutt, A., U. Kollenkirchen, and P. Bertram. 1996. Effect of age and ovariectomy on fibroblastic colony-forming unit numbers in rat bone marrow. Calcif. Tissue Int. 59:309-310.
    • (1996) Calcif. Tissue Int. , vol.59 , pp. 309-310
    • Scutt, A.1    Kollenkirchen, U.2    Bertram, P.3
  • 31
    • 0027510678 scopus 로고
    • Increased proliferation of osteoblast precursor cells in estrogen-deficient rats
    • Modrowski, D., L. Miravet, M. Feuga, and P.J. Marie. 1993. Increased proliferation of osteoblast precursor cells in estrogen-deficient rats. Am. J. Physiol. 264:E190-E196.
    • (1993) Am. J. Physiol. , vol.264
    • Modrowski, D.1    Miravet, L.2    Feuga, M.3    Marie, P.J.4
  • 32
    • 0028925088 scopus 로고
    • Mechanisms of disease: Bone marrow, cytokines, and bone remodeling: emerging insights into the pathophysiology of osteoporosis
    • Manolagas, S.C., and R.L. Jilka. 1995. Mechanisms of disease: bone marrow, cytokines, and bone remodeling: emerging insights into the pathophysiology of osteoporosis. N. Engl. J. Med. 332:305-311.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 305-311
    • Manolagas, S.C.1    Jilka, R.L.2
  • 33
    • 0002266218 scopus 로고
    • The two-stage concept of bone loss revisited
    • Parfitt, A.M. 1992. The two-stage concept of bone loss revisited. Triangle. 31:99-110.
    • (1992) Triangle , vol.31 , pp. 99-110
    • Parfitt, A.M.1
  • 34
    • 0023729554 scopus 로고
    • Bone formation rate in older normal women: Concurrent assessment with bone histomorphometry, calcium kinetics, and biochemical markers
    • Eastell, R., P.D. Delmas, S.F. Hodgson, E.F. Eriksen, K.G. Mann, and B.L. Riggs. 1988. Bone formation rate in older normal women: concurrent assessment with bone histomorphometry, calcium kinetics, and biochemical markers. J. Clin. Endocrinol. Metab. 67:741-748.
    • (1988) J. Clin. Endocrinol. Metab. , vol.67 , pp. 741-748
    • Eastell, R.1    Delmas, P.D.2    Hodgson, S.F.3    Eriksen, E.F.4    Mann, K.G.5    Riggs, B.L.6
  • 36
    • 0029082311 scopus 로고
    • The insulin-like growth factor system and the coupling of formation to resorption
    • Hayden, J.M., S. Mohan, and D.J. Baylink. 1995. The insulin-like growth factor system and the coupling of formation to resorption. Bone. 17(Suppl):93S-98S.
    • (1995) Bone , vol.17 , Issue.SUPPL.
    • Hayden, J.M.1    Mohan, S.2    Baylink, D.J.3
  • 37
    • 0000348680 scopus 로고
    • Suggested sequential mode of control of changes in cell behavior in adult bone remodelling
    • Hattner, R., B.N. Epker, and H.M. Frost. 1965. Suggested sequential mode of control of changes in cell behavior in adult bone remodelling. Nature. 206:489-490.
    • (1965) Nature , vol.206 , pp. 489-490
    • Hattner, R.1    Epker, B.N.2    Frost, H.M.3
  • 38
    • 0342981654 scopus 로고    scopus 로고
    • Effect of alendronate treatment on the osteoclastogenic potential of bone marrow cells in mice
    • van Beek, E.R., C.W. Löwik, and S.E. Papapoulos. 1997. Effect of alendronate treatment on the osteoclastogenic potential of bone marrow cells in mice. Bone. 4:335-340.
    • (1997) Bone , vol.4 , pp. 335-340
    • Van Beek, E.R.1    Löwik, C.W.2    Papapoulos, S.E.3
  • 39
    • 0001030697 scopus 로고    scopus 로고
    • Interleukin-6-type cytokines and their receptors
    • J.P. Bilezikian, L.G. Raisz, and G.A. Rodan, editors. Academic Press, San Diego, CA
    • Manolagas, S.C., R.L. Jilka, T. Bellido, C.A. O'Brien, and A.M. Parfitt. 1996. Interleukin-6-type cytokines and their receptors. In Principles of Bone Biology. J.P. Bilezikian, L.G. Raisz, and G.A. Rodan, editors. Academic Press, San Diego, CA. 701-713.
    • (1996) Principles of Bone Biology , pp. 701-713
    • Manolagas, S.C.1    Jilka, R.L.2    Bellido, T.3    O'Brien, C.A.4    Parfitt, A.M.5
  • 40
    • 0030857451 scopus 로고    scopus 로고
    • Activation of the JAK/STAT signal transduction pathway by IL-6 type cytokines promotes osteoblast differentiation
    • Bellido, T., V.Z.C. Borba, P. Roberson, and S.C. Manolagas. 1997. Activation of the JAK/STAT signal transduction pathway by IL-6 type cytokines promotes osteoblast differentiation. Endocrinology. 138:3666-3676.
    • (1997) Endocrinology , vol.138 , pp. 3666-3676
    • Bellido, T.1    Borba, V.Z.C.2    Roberson, P.3    Manolagas, S.C.4
  • 42
    • 0343474047 scopus 로고
    • Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor
    • Metcalf, D., and D.P. Gearing. 1989. Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor. Proc. Natl. Acad. Sci. USA. 86:5948-5952.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5948-5952
    • Metcalf, D.1    Gearing, D.P.2
  • 43
    • 0028918381 scopus 로고
    • Developmental abnormalities in mice transgenic for bovine oncostatin M
    • Malik, N., U.S. Haugen, B. Modrell, M. Shoyab, and C.H. Clegg. 1995. Developmental abnormalities in mice transgenic for bovine oncostatin M. Mol. Cell Biol. 15:2349-2358.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 2349-2358
    • Malik, N.1    Haugen, U.S.2    Modrell, B.3    Shoyab, M.4    Clegg, C.H.5
  • 44
    • 2642648293 scopus 로고    scopus 로고
    • WAF1.C1P1 gene in osteoblasts: A prerequisite for the biologic effects of IL-6 type cytokines
    • Abstr.
    • WAF1.C1P1 gene in osteoblasts: a prerequisite for the biologic effects of IL-6 type cytokines. J. Bone Miner. Res. 12:S159(Abstr.).
    • (1997) J. Bone Miner. Res. , vol.12
    • Bellido, T.1    Han, L.2    Jilka, R.L.3    Manolagas, S.C.4


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