메뉴 건너뛰기




Volumn 23, Issue 3, 2012, Pages 1151-1161

Premature T cell senescence in Ovx mice is inhibited by repletion of estrogen and medicarpin: A possible mechanism for alleviating bone loss

Author keywords

Immunological senescence; Menopause; Osteoporosis; TNF

Indexed keywords

CD28 ANTIGEN; ESTROGEN; MEDICARPIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84857441459     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-011-1650-x     Document Type: Article
Times cited : (46)

References (42)
  • 1
    • 28544439444 scopus 로고    scopus 로고
    • The role of the immune system in the pathophysiology of osteoporosis
    • DOI 10.1111/j.0105-2896.2005.00334.x
    • JA Clowes BL Riggs S Khosla 2005 The role of the immune system in the pathophysiology of osteoporosis Immunol Rev 208 207 227 16313351 1:CAS:528:DC%2BD28Xks1ehsw%3D%3D 10.1111/j.0105-2896.2005.00334.x (Pubitemid 41746395)
    • (2005) Immunological Reviews , vol.208 , pp. 207-227
    • Clowes, J.A.1    Riggs, B.L.2    Khosla, S.3
  • 2
    • 37249045914 scopus 로고    scopus 로고
    • T cells: Unexpected players in the bone loss induced by estrogen deficiency and in basal bone homeostasis
    • DOI 10.1196/annals.1402.068, Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling
    • MN Weitzmann R Pacifici 2007 T cells: unexpected players in the bone loss induced by estrogen deficiency and in basal bone homeostasis Ann N Y Acad Sci 1116 360 375 18083938 1:CAS:528:DC%2BD1cXitVKgsw%3D%3D 10.1196/annals.1402.068 (Pubitemid 350274346)
    • (2007) Annals of the New York Academy of Sciences , vol.1116 , pp. 360-375
    • Weitzmann, M.N.1    Pacifici, R.2
  • 4
    • 33749354009 scopus 로고    scopus 로고
    • Osteoporosis, inflammation and ageing
    • DOI 10.1186/1742-4933-2-14
    • L Ginaldi MC Di Benedetto M De Martinis 2005 Osteoporosis, inflammation and ageing Immun Ageing 2 14 16271143 10.1186/1742-4933-2-14 (Pubitemid 44848797)
    • (2005) Immunity and Ageing , vol.2 , pp. 14
    • Ginaldi, L.1    Di Benedetto, M.C.2    De Martinis, M.3
  • 5
    • 37249090724 scopus 로고    scopus 로고
    • Osteoporosis - an immune mediated disease?
    • DOI 10.1016/j.ddstr.2007.09.001, PII S1740677307000174, Immunological Disorders / Renal Diseases
    • M De Martinins LP Mengoli L Ginaldi 2007 Osteoporosis-an immune mediated disease? Drug Discov Today Ther Strat 4 3 9 10.1016/j.ddstr.2007.09.001 (Pubitemid 350263749)
    • (2007) Drug Discovery Today: Therapeutic Strategies , vol.4 , Issue.1 , pp. 3-9
    • De Martinis, M.1    Mengoli, L.P.2    Ginaldi, L.3
  • 6
    • 0033708837 scopus 로고    scopus 로고
    • Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha
    • 11086024 1:CAS:528:DC%2BD3cXotlChu78%3D 10.1172/JCI11066
    • S Cenci MN Weitzmann C Roggia N Namba D Novack J Woodring, et al. 2000 Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha J Clin Invest 106 1229 1237 11086024 1:CAS:528:DC%2BD3cXotlChu78%3D 10.1172/JCI11066
    • (2000) J Clin Invest , vol.106 , pp. 1229-1237
    • Cenci, S.1    Weitzmann, M.N.2    Roggia, C.3    Namba, N.4    Novack, D.5    Woodring, J.6
  • 7
    • 28544445957 scopus 로고    scopus 로고
    • The role of T lymphocytes in bone metabolism
    • DOI 10.1111/j.0105-2896.2005.00324.x
    • MN Weitzmann R Pacifici 2005 The role of T lymphocytes in bone metabolism Immunol Rev 208 154 168 16313347 1:CAS:528:DC%2BD28Xks1eitQ%3D%3D 10.1111/j.0105-2896.2005.00324.x (Pubitemid 41746391)
    • (2005) Immunological Reviews , vol.208 , pp. 154-168
    • Weitzmann, M.N.1    Pacifici, R.2
  • 8
    • 34548460388 scopus 로고    scopus 로고
    • T cells and post menopausal osteoporosis in murine models
    • DOI 10.1186/ar2126
    • R Pacifici 2007 T cells and post menopausal osteoporosis in murine models Arthritis Res Ther 9 102 17349065 10.1186/ar2126 (Pubitemid 47354235)
    • (2007) Arthritis Research and Therapy , vol.9 , Issue.2 , pp. 102
    • Pacifici, R.1
  • 9
    • 44949083462 scopus 로고    scopus 로고
    • Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: A key mechanism in osteoporosis
    • 18407820 10.1016/j.bone.2008.02.017
    • P D'Amelio A Grimaldi S Di Bella SZ Brianza MA Cristofaro C Tamone, et al. 2008 Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis Bone 43 92 100 18407820 10.1016/j.bone.2008.02.017
    • (2008) Bone , vol.43 , pp. 92-100
    • D'Amelio, P.1    Grimaldi, A.2    Di Bella, S.3    Brianza, S.Z.4    Cristofaro, M.A.5    Tamone, C.6
  • 10
    • 0032478816 scopus 로고    scopus 로고
    • Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity
    • DOI 10.1074/jbc.273.14.8119
    • AN Vallejo AR Nestel M Schirmer CM Weyand JJ Goronzy 1998 Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity J Biol Chem 273 8119 8129 9525915 1:CAS:528:DyaK1cXitlOhtrw%3D 10.1074/jbc.273.14.8119 (Pubitemid 28168866)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.14 , pp. 8119-8129
    • Vallejo, A.N.1    Nestel, A.R.2    Schirmer, M.3    Weyand, C.M.4    Goronzy, J.J.5
  • 11
    • 1442299281 scopus 로고    scopus 로고
    • T-cell senescence: A culprit of immune abnormalities in chronic inflammation and persistent infection
    • DOI 10.1016/j.molmed.2004.01.002, PII S147149140400019X
    • AN Vallejo CM Weyand JJ Goronzy 2004 T cell senescense: a culprit of immune abnormalities in chronic inflammation and persistent infection Trends Mol Med 10 119 124 15102354 1:CAS:528:DC%2BD2cXhslSktLs%3D 10.1016/j.molmed.2004. 01.002 (Pubitemid 38293347)
    • (2004) Trends in Molecular Medicine , vol.10 , Issue.3 , pp. 119-124
    • Vallejo, A.N.1    Weyand, C.M.2    Goronzy, J.J.3
  • 12
    • 0031472503 scopus 로고    scopus 로고
    • Loss of CD28 expression on T lymphocytes: A marker of replicative senescence
    • DOI 10.1016/S0145-305X(97)00027-X, PII S0145305X9700027X
    • RB Effros 1997 Loss of CD28 expression on T lymphocytes: a marker of replicative senescence Dev Comp Immunol 21 471 478 9463780 1:STN:280: DyaK1c7isV2nsw%3D%3D 10.1016/S0145-305X(97)00027-X (Pubitemid 28030860)
    • (1997) Developmental and Comparative Immunology , vol.21 , Issue.6 , pp. 471-478
    • Effros, R.B.1
  • 13
    • 0033151972 scopus 로고    scopus 로고
    • Modulation of CD28 expression: Distinct regulatory pathways during activation and replicative senescence
    • AN Vallejo JC Brandes CM Weyand JJ Goronzy 1999 Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence J Immunol 162 6572 6579 10352273 1:CAS:528:DyaK1MXjtlKit7w%3D (Pubitemid 29309380)
    • (1999) Journal of Immunology , vol.162 , Issue.11 , pp. 6572-6579
    • Vallejo, A.N.1    Brandes, J.C.2    Weyand, C.M.3    Goronzy, J.J.4
  • 14
    • 0037033105 scopus 로고    scopus 로고
    • Molecular basis for the loss of CD28 expression in senescent T cells
    • DOI 10.1074/jbc.M207352200
    • AN Vallejo E Bryl K Klarskov S Naylor CM Weyand JJ Goronzy 2002 Molecular basis for the loss of CD28 expression in senescent T cells J Biol Chem 277 46940 46949 12324461 1:CAS:528:DC%2BD38XptFSksL8%3D 10.1074/jbc.M207352200 (Pubitemid 36159198)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.49 , pp. 46940-46949
    • Vallejo, A.N.1    Bryl, E.2    Klarskov, K.3    Naylor, S.4    Weyand, C.M.5    Goronzy, J.J.6
  • 15
    • 0031852987 scopus 로고    scopus 로고
    • Replicative senescence: Impact on T cell immunity in the elderly
    • RB Effros 1998 Replicative senescence: impact on T cell immunity in the elderly Aging (Milano) 10 152 1:STN:280:DyaK1czjtVKitg%3D%3D (Pubitemid 28318497)
    • (1998) Aging - Clinical and Experimental Research , vol.10 , Issue.2 , pp. 152
    • Effros, R.B.1
  • 16
    • 0028043586 scopus 로고
    • + T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence
    • DOI 10.1016/0531-5565(94)90073-6
    • RB Effros N Boucher V Porter X Zhu C Spaulding RL Walford, et al. 1994 Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence Exp Gerontol 29 601 609 9435913 1:STN:280:DyaK1c%2FpvVaisA%3D%3D 10.1016/0531-5565(94)90073-6 (Pubitemid 24382608)
    • (1994) Experimental Gerontology , vol.29 , Issue.6 , pp. 601-609
    • Effros, R.B.1    Boucher, N.2    Porter, V.3    Zhu, X.4    Spaulding, C.5    Walford, R.L.6    Kronenberg, M.7    Cohen, D.8    Schachter, F.9
  • 17
    • 0035884911 scopus 로고    scopus 로고
    • Down-regulation of CD28 expression by TNF-alpha
    • 11544310 1:CAS:528:DC%2BD3MXmvFGitLo%3D
    • E Bryl AN Vallejo CM Weyand JJ Goronzy 2001 Down-regulation of CD28 expression by TNF-alpha J Immunol 167 3231 3238 11544310 1:CAS:528: DC%2BD3MXmvFGitLo%3D
    • (2001) J Immunol , vol.167 , pp. 3231-3238
    • Bryl, E.1    Vallejo, A.N.2    Weyand, C.M.3    Goronzy, J.J.4
  • 18
    • 26844513278 scopus 로고    scopus 로고
    • Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis
    • DOI 10.1002/art.21353
    • E Bryl AN Vallejo EL Matteson JM Witkowski CM Weyand JJ Goronzy 2005 Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis Arthritis Rheum 52 2996 3003 16200579 1:CAS:528: DC%2BD2MXhtF2msr3L 10.1002/art.21353 (Pubitemid 41447078)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.10 , pp. 2996-3003
    • Bryl, E.1    Vallejo, A.N.2    Matteson, E.L.3    Witkowski, J.M.4    Weyand, C.M.5    Goronzy, J.J.6
  • 19
    • 34249072897 scopus 로고    scopus 로고
    • The bone-protective effect of the phytoestrogen genistein is mediated via ERalpha-dependent mechanisms and strongly enhanced by physical activity
    • DOI 10.1016/j.bone.2007.02.006, PII S8756328207000646
    • T Hertrampf MJ Gruca J Seibel U Laudenbach KH Fritzemeier P Diel 2007 The bone-protective effect of the phytoestrogen genistein is mediated via ER alpha-dependent mechanisms and strongly enhanced by physical activity Bone 40 1529 1535 17383949 1:CAS:528:DC%2BD2sXlsF2nur0%3D 10.1016/j.bone.2007.02.006 (Pubitemid 46779003)
    • (2007) Bone , vol.40 , Issue.6 , pp. 1529-1535
    • Hertrampf, T.1    Gruca, M.J.2    Seibel, J.3    Laudenbach, U.4    Fritzemeier, K.H.5    Diel, P.6
  • 20
    • 67849088714 scopus 로고    scopus 로고
    • Protective effect of genistein aglycone on the development of osteonecrosis of the femoral head and secondary osteoporosis induced by methylprednisolone in rats
    • 19332450 1:CAS:528:DC%2BD1MXntFGnsb4%3D 10.1677/JOE-08-0552
    • A Bitto F Polito B Burnett R Levy V Di Stefano MA Armbruster, et al. 2009 Protective effect of genistein aglycone on the development of osteonecrosis of the femoral head and secondary osteoporosis induced by methylprednisolone in rats J Endocrinol 201 321 328 19332450 1:CAS:528:DC%2BD1MXntFGnsb4%3D 10.1677/JOE-08-0552
    • (2009) J Endocrinol , vol.201 , pp. 321-328
    • Bitto, A.1    Polito, F.2    Burnett, B.3    Levy, R.4    Di Stefano, V.5    Armbruster, M.A.6
  • 21
    • 77954383266 scopus 로고    scopus 로고
    • Medicarpin inhibits osteoclastogenesis and has nonestrogenic bone conserving effect in ovariectomized mice
    • 20570709 1:CAS:528:DC%2BC3cXos1ykur8%3D 10.1016/j.mce.2010.05.016
    • AM Tyagi AK Gautam A Kumar K Srivastava B Bhargavan R Trivedi, et al. 2010 Medicarpin inhibits osteoclastogenesis and has nonestrogenic bone conserving effect in ovariectomized mice Mol Cell Endocrinol 325 101 109 20570709 1:CAS:528:DC%2BC3cXos1ykur8%3D 10.1016/j.mce.2010.05.016
    • (2010) Mol Cell Endocrinol , vol.325 , pp. 101-109
    • Tyagi, A.M.1    Gautam, A.K.2    Kumar, A.3    Srivastava, K.4    Bhargavan, B.5    Trivedi, R.6
  • 23
    • 0032986491 scopus 로고    scopus 로고
    • + T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice
    • PJ Baker M Dixon RT Evans L Dufour E Johnson DC Roopenian 1999 CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice Infect Immun 67 2804 2809 10338484 1:CAS:528:DyaK1MXjsFSgurg%3D (Pubitemid 29244693)
    • (1999) Infection and Immunity , vol.67 , Issue.6 , pp. 2804-2809
    • Baker, P.J.1    Dixon, M.2    Evans, R.T.3    Dufour, L.4    Johnson, E.5    Roopenian, D.C.6
  • 24
    • 67650261864 scopus 로고    scopus 로고
    • Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis
    • 19519881 10.1186/1742-4933-6-8
    • O Tarjanyi F Boldizsar P Nemeth K Mikecz TT Glant 2009 Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis Immun Ageing 6 8 19519881 10.1186/1742-4933-6-8
    • (2009) Immun Ageing , vol.6 , pp. 8
    • Tarjanyi, O.1    Boldizsar, F.2    Nemeth, P.3    Mikecz, K.4    Glant, T.T.5
  • 25
    • 35048863845 scopus 로고    scopus 로고
    • + T cells in mice
    • DOI 10.1111/j.1365-2567.2007.02667.x
    • E Kozlowska M Biernacka M Ciechomska N Drela 2007 Age-related changes in the occurrence and characteristics of thymic CD4(+) CD25(+) T cells in mice Immunology 122 445 453 17627771 1:CAS:528:DC%2BD2sXht12jtrfO 10.1111/j.1365-2567.2007.02667.x (Pubitemid 47556482)
    • (2007) Immunology , vol.122 , Issue.3 , pp. 445-453
    • Kozlowska, E.1    Biernacka, M.2    Ciechomska, M.3    Drela, N.4
  • 27
    • 0031858870 scopus 로고    scopus 로고
    • Prenylflavonoids: A new class of non-steroidal phytoestrogen (Part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism
    • M Miyamoto Y Matsushita A Kiyokawa C Fukuda Y Iijima M Sugano, et al. 1998 Prenylflavonoids: a new class of non-steroidal phytoestrogen (part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism Planta Med 64 516 519 9741296 1:CAS:528:DyaK1cXltlOqtLc%3D 10.1055/s-2006-957505 (Pubitemid 28383883)
    • (1998) Planta Medica , vol.64 , Issue.6 , pp. 516-519
    • Miyamoto, M.1    Matsushita, Y.2    Kiyokawa, A.3    Fukuda, C.4    Iijima, Y.5    Sugano, M.6    Akiyama, T.7
  • 28
    • 0027744430 scopus 로고
    • In vitro morpho-functional analysis of pancreatic islets isolated from the domestic chicken
    • DOI 10.1016/0040-8166(93)90030-O
    • F Bianchi N Bernardini P Marchetti R Navalesi R Giannarelli A Dolfi, et al. 1993 In vitro morpho-functional analysis of pancreatic islets isolated from the domestic chicken Tissue Cell 25 817 824 8140577 1:STN:280: DyaK2c7ovVyrtw%3D%3D 10.1016/0040-8166(93)90030-O (Pubitemid 24025812)
    • (1993) Tissue and Cell , vol.25 , Issue.6 , pp. 817-824
    • Bianchi, F.1    Bernardini, N.2    Marchetti, P.3    Navalesi, R.4    Giannarelli, R.5    Dolfi, A.6    Lupetti, M.7
  • 29
    • 0028176750 scopus 로고
    • Collagenase distension, two-step sequential filtration, and histopaque gradient purification for consistent isolation of pure pancreatic islets from the market-age (6-month-old) pig
    • P Marchetti R Giannarelli G Villani M Andreozzi L Cruschelli S Cosimi, et al. 1994 Collagenase distension, two-step sequential filtration, and histopaque gradient purification for consistent isolation of pure pancreatic islets from the market-age (6-month-old) pig Transplantation 57 1532 1535 8197621 1:STN:280:DyaK2c3lsF2ntA%3D%3D 10.1097/00007890-199402150-00005 (Pubitemid 24169959)
    • (1994) Transplantation , vol.57 , Issue.10 , pp. 1532-1535
    • Marchetti, P.1    Giannarelli, R.2    Villani, G.3    Andreozzi, M.4    Cruschelli, L.5    Cosimi, S.6    Viacava, P.7    Di Carlo, A.8    Bevilacqua, G.9    Navalesi, R.10
  • 30
    • 0034319148 scopus 로고    scopus 로고
    • Effects of raloxifene, a selective estrogen receptor modulator, on thymus, T cell reactivity, and inflammation in mice
    • DOI 10.1006/cimm.2000.1719
    • MC Erlandsson E Gomori M Taube H Carlsten 2000 Effects of raloxifene, a selective estrogen receptor modulator, on thymus, T cell reactivity, and inflammation in mice Cell Immunol 205 103 109 11104582 1:CAS:528: DC%2BD3cXosVOmt74%3D 10.1006/cimm.2000.1719 (Pubitemid 32005726)
    • (2000) Cellular Immunology , vol.205 , Issue.2 , pp. 103-109
    • Erlandsson, M.C.1    Gomori, E.2    Taube, M.3    Carlsten, H.4
  • 31
    • 56549089663 scopus 로고    scopus 로고
    • Oxidative stress, free radicals and bone remodeling
    • 18847368 1:CAS:528:DC%2BD1cXhsVOjtLzJ 10.1515/CCLM.2008.302
    • G Banfi EL Iorio MM Corsi 2008 Oxidative stress, free radicals and bone remodeling Clin Chem Lab Med 46 1550 1555 18847368 1:CAS:528:DC%2BD1cXhsVOjtLzJ 10.1515/CCLM.2008.302
    • (2008) Clin Chem Lab Med , vol.46 , pp. 1550-1555
    • Banfi, G.1    Iorio, E.L.2    Corsi, M.M.3
  • 34
    • 84855854953 scopus 로고    scopus 로고
    • Osteoporosis and inflammation
    • 18240539 10.1301/nr.2007.dec.S147-S151
    • GR Mundy 2007 Osteoporosis and inflammation Nutr Rev 65 S147 S151 18240539 10.1301/nr.2007.dec.S147-S151
    • (2007) Nutr Rev , vol.65
    • Mundy, G.R.1
  • 36
    • 0025084320 scopus 로고
    • Influence of growth hormone on the immunosuppressive effect of prednisolone in mice
    • P Franco O Marelli D Lattuada V Locatelli D Cocchi EE Muller 1990 Influence of growth hormone on the immunosuppressive effect of prednisolone in mice Acta Endocrinol (Copenh) 123 339 344 1:CAS:528:DyaK3MXisVSru7s%3D (Pubitemid 20340324)
    • (1990) Acta Endocrinologica , vol.123 , Issue.3 , pp. 339-344
    • Franco, P.1    Marelli, O.2    Lattuada, D.3    Locatelli, V.4    Cocchi, D.5    Muller, E.E.6
  • 38
    • 0037951860 scopus 로고    scopus 로고
    • Dietary n-3 Fatty Acids Decrease Osteoclastogenesis and Loss of Bone Mass in Ovariectomized Mice
    • DOI 10.1359/jbmr.2003.18.7.1206
    • D Sun A Krishnan K Zaman R Lawrence A Bhattacharya G Fernandes 2003 Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice J Bone Miner Res 18 1206 1216 12854830 1:CAS:528: DC%2BD3sXlsFGktL8%3D 10.1359/jbmr.2003.18.7.1206 (Pubitemid 37294913)
    • (2003) Journal of Bone and Mineral Research , vol.18 , Issue.7 , pp. 1206-1216
    • Sun, D.1    Krishnan, A.2    Zaman, K.3    Lawrence, R.4    Bhattacharya, A.5    Fernandes, G.6
  • 40
    • 20444441960 scopus 로고    scopus 로고
    • Estrogen reduces angiotensin II-induced acceleration of senescence in endothelial progenitor cells
    • DOI 10.1291/hypres.28.263
    • T Imanishi T Hano I Nishio 2005 Estrogen reduces angiotensin II-induced acceleration of senescence in endothelial progenitor cells Hypertens Res 28 263 271 16097371 1:CAS:528:DC%2BD2MXltlCqs70%3D 10.1291/hypres.28.263 (Pubitemid 40812612)
    • (2005) Hypertension Research , vol.28 , Issue.3 , pp. 263-271
    • Imanishi, T.1    Hano, T.2    Nishio, I.3
  • 41
    • 0142217368 scopus 로고    scopus 로고
    • Hydrogen peroxide induced down-regulation of CD28 expression of Jurkat cells is associated with a change of site alpha-specific nuclear factor binding activity and the activation of caspase-3
    • DOI 10.1016/S0531-5565(03)00166-9
    • S Ma H Ochi L Cui J Zhang W He 2003 Hydrogen peroxide induced down-regulation of CD28 expression of Jurkat cells is associated with a change of site alpha-specific nuclear factor binding activity and the activation of caspase-3 Exp Gerontol 38 1109 1118 14580864 1:CAS:528:DC%2BD3sXot12jtr8%3D 10.1016/S0531-5565(03)00166-9 (Pubitemid 37324422)
    • (2003) Experimental Gerontology , vol.38 , Issue.10 , pp. 1109-1118
    • Ma, S.1    Ochi, H.2    Cui, L.3    Zhang, J.4    He, W.5
  • 42
    • 79251622710 scopus 로고    scopus 로고
    • The effects of estrogen receptors alpha- and beta-specific agonists and antagonists on cell proliferation and energy metabolism in human bone cell line
    • 21268084 1:CAS:528:DC%2BC3MXhtVehu7s%3D 10.1002/jcb.22959
    • D Somjen S Katzburg O Sharon M Grafi-Cohen E Knoll N Stern 2011 The effects of estrogen receptors alpha- and beta-specific agonists and antagonists on cell proliferation and energy metabolism in human bone cell line J Cell Biochem 112 2 625 632 21268084 1:CAS:528:DC%2BC3MXhtVehu7s%3D 10.1002/jcb.22959
    • (2011) J Cell Biochem , vol.112 , Issue.2 , pp. 625-632
    • Somjen, D.1    Katzburg, S.2    Sharon, O.3    Grafi-Cohen, M.4    Knoll, E.5    Stern, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.