The basic property of Lys385 is important for potentiation of the human α1 glycine receptor by ethanol

Journal of Pharmacology and Experimental Therapeutics

Volumn 340, Issue 2, 2012, Pages 339-349

  Castro, Patricio A ^a   Figueroa, Maximiliano ^a,b   Yevenes, Gonzalo E ^a,c   San Martin, Loreto S ^a   Aguayo, Luis G ^a  

^a UNIVERSITY OF CONCEPCIÓN   (Chile)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; GLUTAMIC ACID; GLUTAMINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA1 SUBUNIT; LEUCINE; LYSINE; METHANETHIOSULFONATE; REAGENT; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BIOCHEMISTRY; CELL STRAIN HEK293; CONTROLLED STUDY; GENE DELETION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; INTRACELLULAR RECORDING; MOLECULAR INTERACTION; MOLECULAR MODEL; PATCH CLAMP; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY;

AMINO ACID SUBSTITUTION; CELL MEMBRANE; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ELECTROPHYSIOLOGICAL PHENOMENA; ETHANOL; ETHYL METHANESULFONATE; GLYCINE; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HEK293 CELLS; HUMANS; ION CHANNEL GATING; LYSINE; MODELS, MOLECULAR; NEUROTRANSMITTER AGENTS; PATCH-CLAMP TECHNIQUES; PHYSICOCHEMICAL PHENOMENA; PROPOFOL; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, GLYCINE; RECOMBINANT FUSION PROTEINS; STATIC ELECTRICITY; SURFACE PROPERTIES; TRANSFECTION;

EID: 84856002611     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.185140     Document Type: Article

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