Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor

Journal of Biological Chemistry

Volumn 283, Issue 28, 2008, Pages 19301-19313

  Livesey, Matthew R ^a   Cooper, Michelle A ^a   Deeb, Tarek Z ^b   Carland, Jane E ^a   Kozuska, Janna ^a   Hales, Tim G ^b   Lambert, Jeremy J ^a   Peters, John A ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; ANIMAL CELL CULTURE; CAPILLARITY; CESIUM; HEAT CONDUCTION; LIQUIDS; ORGANIC ACIDS; POLARIZATION;

ARGININE RESIDUES; ASPARTATE; CONDUCTION PATHWAYS; CYTOPLASMIC DOMAINS; EXTRACELLULAR; HIGH PERMEABILITIES; INHIBITORY EFFECTS; ION CHANNELS; IONIC SELECTIVITIES; MACROSCOPIC CURRENTS; SINGLE CHANNELS; STRUCTURAL DETERMINANTS;

CALCIUM;

ALANINE; AMINO ACID; ARGININE; ASPARTIC ACID; CALCIUM CHANNEL; CALCIUM ION; CATION; CYSTEINE; GLUTAMINE; SEROTONIN 3A RECEPTOR; CALCIUM; PROTEIN SUBUNIT; SEROTONIN 3 RECEPTOR;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL GRANULE; CONTROLLED STUDY; EMBRYO; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; ION PERMEABILITY; MUTATION; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; TRANSPORT KINETICS; WILD TYPE; AMINO ACID SUBSTITUTION; CELL LINE; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; CALCIUM; CELL LINE; CELL MEMBRANE PERMEABILITY; HUMANS; ION CHANNEL GATING; MUTATION; NEURONS; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, SEROTONIN, 5-HT3;

EID: 50349086199     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802406200     Document Type: Article

References (51)

1. Alexander, S. P. H., Mathie, A., and Peters, J. A. (2008) Br. J. Pharmacol. 153, Suppl. 2, S1-S207
2. Peters, J. A., Hales, T. G., and Lambert, J. J. (2005) Trends Pharmacol. Sci. 26, 587-594
3. Thompson, A. J., and Lummis, S. C. R. (2006) Curr. Pharm. Des. 12, 3615-3630
4. Sugita, S., Shen, K. Z., and North, R. A. (1992) Neuron 8, 199-203
5. Roerig, B., Nelson, D. A., and Katz, L. C. (1997) J. Neurosci. 17, 8353-8362
6. Zhou, F. M., and Hablitz, J. J. (1999) J. Neurophysiol. 82, 2989-2999
7. Férézou, I., Cauli, B., Hill, E. L., Rossier, J., Hamel, E., and Lambolez, B. (2002) J. Neurosci. 22, 7389-7397
8. Chameau, P., and van Hooft, J. A. (2006) Cell Tissue Res. 326, 573-581
9. Fink, K. B., and Göthert, M. (2007) Pharmacol. Rev. 59, 360-417
10. Maricq, A. V., Peterson, A. S., Brake, A. J., Myers, R. M., and Julius, D. (1991) Science 254, 432-437
11. Davies, P. A., Pistis, M., Hanna, M. C., Peters, J. A., Lambert, J. J., Hales, T. G., and Kirkness, E. F. (1999) Nature 397, 359-363
12. Dubin, A. E., Huvar, R., D-Andrea, M. R., Pyati, J., Zhu, J. Y., Joy, K. C., Galindo, J. E., Glass, C. A., Luo, L., Jackson, M. R., Lovenberg, T. W., and Erlander, M. G. (1999) J. Biol. Chem. 274, 30799-30810
13. Niesler, B., Frank, B., Kapeller, J., and Rappold, G. A. (2003) Gene 310, 101-111
14. Niesler, B., Walstab, J., Combrink, S., Möller, D., Kapeller, J., Rietdorf, J., Bönisch, H., Gothert, M., Rappold, G., and Brüss, M. (2007) Mol. Pharmacol. 72, 8-17
15. Karnovsky, A. M., Gotow, L. F., McKinley, D. D., Piechan, J. L., Mills, C. J., Schellin, K. A., Slightom, J. L., Fitzgerald, L. R., Benjamin, C. W., and Roberds, S. L. (2003) Gene 319, 137-148
16. Barrera, N. P., Herbert, P., Henderson, R. M., Martin, I. L., and Edwardson, J. M. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 12595-12600
17. Boyd, G. W., Low, P., Dunlop, J. I., Robertson, L. A., Vardy, A., Lambert, J. J., Peters, J. A., and Connolly, C. N. (2002) Mol. Cell. Neurosci. 21, 38 -50
18. Hu, X. Q., and Peoples, R. W. (2008) J. Biol. Chem. 283, 6826-6831
19. Solt, K., Stevens, R. J., Davies, P. A., and Raines, D. E. (2005) J. Pharmacol. Exp. Ther. 315, 771-776
20. Brown, A. M., Hope, A. G., Lambert, J. J., and Peters, J. A. (1998) J. Physiol. 507, 653-665
21. Mochizuki, S., Miyake, A., and Furuichi, K. (1999) Amino Acids 17, 243-255
22. Hales, T. G., Dunlop, J. I., Deeb, T. Z., Carland, J. E., Kelley, S. P., Lambert, J. J., and Peters, J. A. (2006) J. Biol. Chem. 281, 8062-8071
23. Krzywkowski, K., Davies, P. A., Feinberg-Zadek, P. L., Bräuner-Osborne, H., and Jensen, A. A. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 722-727
24. Brüss, M., Barann, M., Hayer-Zillgen, M., Eucker, T., Göthert, M., and Bönisch, H. (2000) Naunyn-Schmiedeberg's Arch. Pharmacol. 362, 392-401
25. Krzywkowski, K., Jensen, A. A., Connolly, C. N., and Bräuner- Osborne, H. (2007) Pharmacogenet. Genomics 17, 255-266
26. Unwin, N. (2005) J. Mol. Biol. 346, 967-989
27. Sine, S. M., and Engel, A. G. (2006) Nature 440, 448-455
28. Keramidas, A., Moorhouse, A. J., Schofield, P. R., and Barry, P. H. (2004) Prog. Biophys. Mol. Biol. 86, 161-204
29. Gunthorpe, M. J., and Lummis, S. C. R. (2001) J. Biol. Chem. 276, 10977-10983
30. Thompson, A., and Lummis, S. C. R. (2003) Br. J. Pharmacol. 140, 359-365
31. Kelley, S. P., Dunlop, J. I., Kirkness, E. F., Lambert, J. J., and Peters, J. A. (2003) Nature 424, 321-324
32. Deeb, T. Z., Carland, J. E., Cooper, M. A., Livesey, M. R., Lambert, J. J., Peters, J. A., and Hales, T. G. (2007) J. Biol. Chem. 282, 6172-6182
33. Reeves, D. C., Jansen, M., Bali, M., Lemster, T., and Akabas, M. H. (2005) J. Neurosci. 25, 9358-9366
34. Hu, X. Q., and Lovinger, D. M. (2005) J. Physiol. 568, 381-396
35. Fenwick, E. M., Marty, A., and Neher, E. (1982) J. Physiol. 331, 577-597
36. Butler, J. N. (1968) Biophys. J. 8, 1426-1433
37. Wang, J., Liu, W., Fan, J., and Lu, J. (1994) J. Chem. Soc. Faraday Trans. 90, 3281-3285
38. Lewis, C. A. (1979) J. Physiol. 286, 417-445
39. Hille, B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associates, Sunderland, MA
40. Gill, C. H., Peters, J. A., and Lambert, J. J. (1995) Br. J. Pharmacol. 114, 1211-1221
41. Niemeyer, M. I., and Lummis, S. C. R. (2001) Eur. J. Pharmacol. 428, 153-161
42. Hubbard, P. C., and Lummis, S. C. R. (2000) Eur. J. Pharmacol. 394, 189-197
43. Jensen, M. L., Schousboe, A., and Ahring, P. K. (2005) J. Neurochem. 92, 217-225
44. Jansen, M., Bali, M., and Akabas, M. H. (2008) J. Gen. Physiol., 131, 137-146
45. Dekker, E. R., and Dani, J. A. (1990) J. Neurosci. 10, 3413-3420
46. Ivanov, I., Cheng, X., Sine, S. M., and McCammon, J. A. (2007) J. Am. Chem. Soc. 129, 8217-8224
47. Wang, H.-L., Cheng, X., Taylor, P., McCammon, J. A., and Sine, S. M. (2008) PloS Comput. Biol. 4, e41
48. Tapia, L., Kuryatov, A., and Lindstrom, J. (2007) Mol. Pharmacol. 71, 769-776
49. Panicker, S., Cruz, H., Arrabit, C., and Slesinger, P. A. (2002) J. Neurosci. 22, 1629-1639
50. Hilf, R. J. C., and Dutzler, R. (2008) Nature 452, 375-379
51. Belleli, D., Balcarek, J. M., Hope, A. G., Peters, J. A., Lambert, J. J., and Blackburn, T. P. (1995) Mol. Pharmacol. 48, 1054-1062