Potentiation of the glycine-activated Cl- current by ethanol in cultured mouse spinal neurons

Journal of Pharmacology and Experimental Therapeutics

Volumn 279, Issue 3, 1996, Pages 1116-1122

  Aguayo, Luis G ^a   Tapia, Juan C ^a   Pancetti, Floria C ^a,b  

^a UNIVERSITY OF CONCEPCIÓN   (Chile)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCINE;

ANIMAL CELL; ARTICLE; CHLORIDE CURRENT; DRUG POTENTIATION; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPINAL CORD NERVE CELL;

ANIMALS; CHLORIDE CHANNELS; CHOLERA TOXIN; DRUG SYNERGISM; ENZYME ACTIVATION; ENZYME INHIBITORS; ETHANOL; GAMMA-AMINOBUTYRIC ACID; GLYCINE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MICE; MICE, INBRED C57BL; N-METHYLASPARTATE; NEURONS; PERTUSSIS TOXIN; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; SPINAL CORD; VIRULENCE FACTORS, BORDETELLA;

EID: 0030438454     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. AGUAYO, L. G. AND GROSSIE, J.: Dopamine inhibits a sustained calcium current through activation of alpha adrenergic receptors and a GTP-binding protein in adult rat sympathetic neurons. J. Pharmacol. Exp. Ther. 269: 503-508, 1994.
2. - current in cultured mouse neurons. J. Pharmacol. Exp. Ther. 270: 61-69, 1994.
3. AGUAYO, L. G., PANCETTI, F. C., KLEIN, R. L. AND HARRIS, A. R.: Differential effects of GABAergic ligands in mouse and rat hippocampal neurons. Brain Res. 647: 97-105, 1994.
4. i-mediated adenylate cyclase inhibitory response in rat brain cortex in vitro. FEBS Lett. 219: 296-300, 1987.
5. BECKER, D. M., HOCK, W. AND BETZ, H.: Glycine receptor heterogeneity in rat spinal cord during postnatal development. EMBO J. 7: 3717-3726, 1988.
6. BETZ, H.: Glycine receptors: Heterogenous and widespread in the mammalian brain. Trends Neurosci. 14: 458-461, 1991.
7. BODE, D. C. AND MOLINOFF, P. B.: Effects of ethanol in vitro on the beta adrenergic receptor-coupled adenylate cyclase system. J. Pharmacol. Exp. Ther. 246: 1040-1047, 1988.
8. CARR, C., LONEY, C., UNSON, C., KNOWLER, J. AND MILLIGAN, G.: Chronic exposure of rat glioma C6 cells to cholera toxin induces loss of the α-subunit of the stimulatory guanine nucleotide-binding protein. Eur. J. Pharmacol. 188: 203-209, 1990.
9. CELENTANO, J. J., GIBBS, T. T. AND FARB, D. H.: Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons. Brain Res. 455: 377-380, 1988.
10. CHEN, H.-C., KEMP, B. E., PEARSON, R. B., SMITH, A. J., MISCONI, L., VAN PATTEN, S. M. AND WALSH, D. A.: A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J. Biol. Chem. 261: 989-992, 1986.
11. CHERUBINI, E., GAIARSA, J. L. AND BEN-ARI, Y.: GABA: An excitatory transmitter in early postnatal life. Trends Neurosci. 14: 515-519, 1991.
12. FELDMAN, A. M., LEVINE, M. A., CATES, A. E. BAUGHMAN, K. L. VAN DOP, C.: Multiple effects of ethanol on cardiac adenylate cyclase. J. Cardiovasc. Pharmacol. 13: 774-780, 1989.
13. GRENNINGLOH, G., PRIBILLA, I., PRIOR, P., MULTHAUP, G., BEYREUTHER, K., TALEB, O. AND BETZ, H.: Cloning and expression of the 58 kd β subunit of the inhibitory glycine receptor. Neuron 4: 963-970, 1990.
14. HAMILL, O. P., MARTY, A., NEHER, E., SAKMANN, B. AND SIGWORTH, F. J.: Improved patch-clamp techniques for high-resolution current recordings from cells and cell-free membrane patches. Pflügers Arch. 391: 85-100, 1981.
15. HIDAKA, H. INAGAKI, M., KAWAMOTO, S. AND SASAKI, Y.: Isoquinolinesulfon-amides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23: 5036-5041, 1984.
16. HOFFMAN, P. L. AND TABAKOFF, B.: Ethanol and guanine nucleotide binding proteins: A selective interaction. Fed. Am. Soc. Exp. Biol. J. 4: 2612-2622, 1990.
17. ITO, S. AND CHERUBINI, E.: Strychnine-sensitive glycine responses of neonatal rat hippocampal neurons. J. Physiol. (Lond.) 440: 67-83, 1991.
18. KUHSE, J., SCHMIEDEN, V. AND BETZ, H.: A single amino acid exchange alters the pharmacology of neonatal rat glycine receptor subunit. Neuron 5: 867-873, 1990.
19. 3 receptor-mediated ion current in neuroblastoma and isolated adult mammalian neurons. Mol. Pharmacol. 40: 263-270, 1991.
20. LOVINGER, D. M., WHITE, G. AND WEIGHT, F. F.: Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science (Wash. DC) 243: 1721-1724, 1989.
21. LUTHIN, G. R. AND TABAKOFF, B.: Activation of adenylate cyclase by alcohols requires the nucleotide-binding protein. J. Pharmacol. Exp. Ther. 228: 579-587, 1984.
22. MALOSIO, M. L., GRENNINGLOH, G., KUHSE, J., SCHMIEDEN, V., SCHMITT, B., PRIOR, P. AND BETZ, H.: Alternative splicing generates two variants of the α1 subunit of the inhibitory glycine receptor. J. Biol. Chem. 266: 2048-2053, 1991.
23. A-gated chloride channels. J. Pharmacol. Exp. Ther. 246: 558-564, 1988.
24. RABIN, R. A. AND MOLINOFF, P. B.: Activation of adenylate cyclase by ethanol in mouse striatal tissue. J. Pharmacol. Exp. Ther. 216: 129-134, 1981.
25. RABIN, R. A. AND MOLINOFF, P. B.: Multiple sites of action of ethanol on adenylate cyclase. J. Pharmacol. Exp. Ther. 227: 551-556, 1983.
26. RALL, T. W.: Hypnotics and sedatives; ethanol. In The Goodman & Gilman's Pharmacological Basis of Therapeutics, ed. by A. Goodman, T. W. Rall, A. S. Nies and P. Taylor, 8th ed., pg. 345-380, Pergamon Press, Inc., New York, 1990.
27. SCHWARTZ, R. D., HEUSCHNEIDER, G., EDGAR, P. P. AND COHN, J. A.: cAMP analog inhibits γ-aminobutyric acid-gated chloride flux and activates protein kinase A in brain synaptoneurosomes. Mol. Pharmacol. 39: 370-375, 1991.
28. SCHMID, K., BOHMER, G. AND GEBAUER, K.: Glycine receptor-mediated fast synaptic inhibition in the brainstem respiratory system. Respir. Physiol. 84: 351-361, 1991.
29. ca channels by Gsα independent of phosphorylation by protein kinase A. Am. J. Physiol. 265: H1460-H1465, 1993.
30. SMITH, T. L.: Selective effects of acute and chronic ethanol exposure on neuropeptide and guanine nucleotide stimulated phospholipase C activity in intact N1E-115 neuroblastoma. J. Pharmacol. Exp. Ther. 258: 410-415, 1991.
31. SONG, Y. AND HUANG, L. Y. M.: Modulation of glycine receptor chloride channels by cAMP-dependent protein kinase in spinal trigeminal neurones. Nature (Lond.) 348: 242-245, 1990.
32. ST. JOHN, P. A. AND STEPHENS, S. L.: Adult-type glycine receptors form clusters on embryonic rat spinal cord neurons developing in vitro. J. Neurosci. 13: 2749-2757, 1993.
33. VAELLO, M. L., GOMEZ, A. R., LERMA, J. AND MAYOR, F., JR.: Modulation of inhibitory glycine receptors by phosphorylation by protein kinase C and cAMP-dependent protein kinase. J. Biol. Chem. 269: 2002-2008, 1994.
34. WALSH, K. B., BEGENISICH, T. B. AND KASS, R. S.: β-Adrenergic modulation in the heart. Independent regulation of K and Ca channels. Pflügers Arch. 411: 232-234, 1988.
35. WALSH, K. B. AND KASS, R. S.: Regulation of a heart potassium channel by protein kinase A and C. Science (Wash. DC) 242: 67-69, 1988.
36. A-mediated synaptic current by ethanol in hippocampal CA1 neurons: Possible role of protein kinase C. J. Pharmacol. Exp. Ther. 268: 1388-1395, 1994a.
37. A-mediated synaptic currents in hippocampal CA1 neurons. Brain Res. 665: 307-310, 1994b.
38. 2+ channels of sympathetic neurons via a pertussis toxin-insensitive but cholera toxin-sensitive pathway. Neuron 13: 657-669, 1994.