Targeting pathophysiological rhythms: Prednisone chronotherapy shows sustained efficacy in rheumatoid arthritis

Annals of the Rheumatic Diseases

Volumn 69, Issue 7, 2010, Pages 1275-1280

  Buttgereit, Frank ^a   Doering, Gisela ^b   Schaeffler, Achim ^c   Witte, Stephan ^c   Sierakowski, Stanislaw ^d   Gromnica Ihle, Erika ^e   Jeka, Slawomir ^f   Krueger, Klaus ^g   Szechinski, Jacek ^h   Alten, Rieke ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MERCK KGAA   (Germany)

^c Nitec Pharma GmbH   (Germany)

^d MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^e MARTIN LUTHER KRANKENHAUS   (Germany)

^f Clinical Trials Office   (Poland)

^g Praxiszentrum St Bonifatius   (Germany)

^h Katedra I Klinika Reumatologii I Chorob Wewnetrznych AM   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE MODIFYING ANTIRHEUMATIC DRUG; GLUCOCORTICOID; INTERLEUKIN 6; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISONE; ANTIRHEUMATIC AGENT;

ABDOMINAL PAIN; ARTICLE; BACKACHE; BLINDNESS; BLOOD LEVEL; CHRONOTHERAPY; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DRUG RELEASE; DRUG SAFETY; DRUG TOLERABILITY; EVENING DOSAGE; GASTRITIS; GASTROINTESTINAL DISEASE; GASTROINTESTINAL HEMORRHAGE; HUMAN; INFECTION; JOINT; LABORATORY; LOW DRUG DOSE; MORNING STIFFNESS; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE; PATHOPHYSIOLOGY; PLASMA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; RHEUMATOLOGY; RIGIDITY; RISK BENEFIT ANALYSIS; SCORING SYSTEM; SIDE EFFECT; STOMACH PERFORATION; UPPER RESPIRATORY TRACT INFECTION; WEIGHT GAIN; ADULT; AGED; CIRCADIAN RHYTHM; DELAYED RELEASE FORMULATION; FEMALE; HOSPITALIZATION; MALE; MIDDLE AGED; TREATMENT OUTCOME;

ADULT; AGED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CIRCADIAN RHYTHM; DELAYED-ACTION PREPARATIONS; DOUBLE-BLIND METHOD; FEMALE; GLUCOCORTICOIDS; HUMANS; MALE; MIDDLE AGED; PREDNISONE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77954979202     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2009.126888     Document Type: Article

References (17)

1. Westhoff G, Buttgereit F, Gromnica-Ihle E, et al. Morning stiffness and its influence on early retirement in patients with recent onset rheumatoid arthritis. Rheumatology (Oxford) 2008;47:980-4.
2. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
3. Ranganath VK, Khanna D, Paulus HE. ACR remission criteria and response criteria. Clin Exp Rheumatol 2006;24(6 Suppl 43):S14-21.
4. Khurana R, Berney SM. Clinical aspects of rheumatoid arthritis. Pathophysiology 2005;12:153-65.
5. Buttgereit F, Doering G, Schaeffler A, et al. Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial. Lancet 2008;371:205-14.
6. Straub RH, Cutolo M. Circadian rhythms in rheumatoid arthritis: implications for pathophysiology and therapeutic management. Arthritis Rheum 2007;56:399-408.
7. Cutolo M, Masi AT. Circadian rhythms and arthritis. Rheum Dis Clin North Am 2005;31:115-29, ix-x.
8. Cutolo M, Seriolo B, Craviotto C, et al. Circadian rhythms in RA. Ann Rheum Dis 2003;62:593-6.
9. Arvidson NG, Gudbjörnsson B, Elfman L, et al. Circadian rhythm of serum interleukin-6 in rheumatoid arthritis. Ann Rheum Dis 1994;53:521-4.
10. Cutolo M, Villaggio B, Otsa K, et al. Altered circadian rhythms in rheumatoid arthritis patients play a role in the disease's symptoms. Autoimmun Rev 2005;4:497-502.
11. Perry MG, Kirwan JR, Jessop DS, et al. Overnight variations in cortisol, interleukin 6, tumour necrosis factor alpha and other cytokines in people with rheumatoid arthritis. Ann Rheum Dis 2009;68:63-8.
12. Bijlsma JW, Jacobs JW. Glucocorticoid chronotherapy in rheumatoid arthritis. Lancet 2008;371:183-4.
13. Da Silva JA, Jacobs JW, Kirwan JR, et al. Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data. Ann Rheum Dis 2006;65:285-93.
14. Da Silva JA, Jacobs JW, Bijlsma JW. Revisiting the toxicity of low-dose glucocorticoids: risks and fears. Ann N Y Acad Sci 2006;1069:275-88.
15. Alten R, Doering G, Cutolo M, et al. Hypothalamus-pituitary-adrenal (HPA) axis function in patients with rheumatoid arthritis (RA) treated with a new night-time-release prednisone. J Rheumatol 2010; (in press).
16. Cutolo M, Straub RH. Polymyalgia rheumatica: evidence for a hypothalamic-pituitary-adrenal axis-driven disease. Clin Exp Rheumatol 2000;18:655-8.
17. Cutolo M, Cimmino MA, Sulli A. Polymyalgia rheumatica vs late-onset rheumatoid arthritis. Rheumatology (Oxford) 2009;48:93-5.