Glucocorticoid-mediated inhibition of Lck modulates the pattern of T cell receptor-induced calcium signals by down-regulating inositol 1,4,5-trisphosphate receptors

Journal of Biological Chemistry

Volumn 284, Issue 46, 2009, Pages 31860-31871

  Harr, Michael W ^a   Rong, Yiping ^a   Bootman, Martin D ^b   Roderick, H Llewelyn ^b,c   Distelhorst, Clark W ^a,d,e  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

^e UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM OSCILLATION; CALCIUM SIGNALING; DEXAMETHASONES; GLUCOCORTICOIDS; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN-2; LOW CONCENTRATIONS; SIGNALING EVENTS; SRC-FAMILY KINASE; T CELL RECEPTOR; T-CELL RECEPTORS;

ALCOHOLS; CALCIUM ALLOYS; CELL MEMBRANES; ELECTRIC REACTORS; INTERNET PROTOCOLS; SIGNALING; SUGARS; THERMAL CONDUCTIVITY OF SOLIDS;

CALCIUM;

DEXAMETHASONE; GLUCOCORTICOID; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; INTERLEUKIN 2; MESSENGER RNA; PROTEIN KINASE LCK; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GENE ACTIVATION; GENE EXPRESSION; IMMUNOMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STIMULATION; T LYMPHOCYTE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; DEXAMETHASONE; IMMUNOPRECIPITATION; INOSITOL 1,4,5-TRISPHOSPHATE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; THYMOMA; THYMUS NEOPLASMS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 70450246916     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.005579     Document Type: Article

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