Characterization of activity and binding mode of glycyrrhetinic acid derivatives inhibiting 11β-hydroxysteroid dehydrogenase type 2

Journal of Steroid Biochemistry and Molecular Biology

Volumn 125, Issue 1-2, 2011, Pages 129-142

  Kratschmar, Denise V ^a   Vuorinen, Anna ^b   Da Cunha, Thierry ^a   Wolber, Gerhard ^c,d   Classen Houben, Dirk ^e   Doblhoff, Otto ^e   Schuster, Daniela ^b   Odermatt, Alex ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d Inte:Ligand GmbH   (Austria)

^e Onepharm Research and Development GmbH   (Austria)

Author keywords

11 Hydroxysteroid dehydrogenase; Glucocorticoid; Glycyrrhetinic acid; Inhibitor; Pharmacophore; Steroid metabolism

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; CARBOXYL GROUP; GLUCOCORTICOID RECEPTOR; GLYCYRRHETINIC ACID DERIVATIVE; HYDROXYL GROUP; RECOMBINANT ENZYME;

ANIMAL CELL; ARTICLE; BIOASSAY; CANCER CELL CULTURE; CELL LYSATE; COLON CANCER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG DETERMINATION; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANIMALS; GLUCOCORTICOIDS; GLYCYRRHETINIC ACID; HEK293 CELLS; HUMANS; ISOENZYMES; MALE; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLUCOCORTICOID;

GLYCYRRHIZA;

EID: 79957758271     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.12.019     Document Type: Article

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