Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase

Steroids

Volumn 77, Issue 3, 2012, Pages 212-223

  Chiellini, Grazia ^a,b   Rapposelli, Simona ^b   Zhu, Jinge ^a   Massarelli, Ilaria ^c   Saraceno, Marilena ^b   Bianucci, Anna Maria ^b,d   Plum, Lori A ^a   Clagett Dame, Margaret ^a   Deluca, Hector F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF PISA   (Italy)

^c Istituto Nazionale per la Scienza e la Tecnologia Dei Materiali   (Italy)

^d International Centre for Studies and Research in Biomedicine ICB   (Luxembourg)

Author keywords

1,25 Dihydroxyvitamin D 3; Cancer therapy; Cyclopropylamines; CYP24A1; Cytochrome P450 inhibitors; Molecular docking

Indexed keywords

2 METHYLENE 22 (IMIDAZOL 1 YL) 19,23,24,25,26,27 ESANOR 1ALPHA HYDROXYVITAMIN D3; CYTOCHROME P450; CYTOCHROME P450 24A1; CYTOCHROME P450 27B1; CYTOCHROME P450 INHIBITOR; IMIDAZOLE DERIVATIVE; ISOENZYME; N CYCLOPROPYL 2 METHYLENE 19,25,26,27 TETRANOR 25 AZA 1ALPHA HYDROXYVITAMIN D; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FREE SYSTEM; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HORNER REACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOBLAST; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; AMINO ACID SEQUENCE; ANIMALS; CALCIFEDIOL; CALCIUM; CELL DIFFERENTIATION; CYCLOPROPANES; ENZYME ACTIVATION; ENZYME INHIBITORS; HALF-LIFE; HL-60 CELLS; HUMANS; HYDROXYCHOLECALCIFEROLS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR SEQUENCE DATA; OSTEOBLASTS; RATS; SEQUENCE HOMOLOGY, AMINO ACID; STEROID HYDROXYLASES; TRANSCRIPTIONAL ACTIVATION; VITAMIN D;

EID: 84855900039     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.11.007     Document Type: Article

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