Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H- naphthalen-1-one (tetralone) derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 22, 2004, Pages 5651-5654

  Yee, Sook Wah ^a   Simons, Claire ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

2 Substituted 3,4 dihydro 2H naphthalen 1 one (tetralone) derivatives; 24 Hydroxylase (CYP24); Differentiating therapy; Enzyme inhibition

Indexed keywords

2 BENZYL 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 2 BENZYLIDENE 3,4 DIHYDRO 2H NAPHTHALEN 1 ONE; 25 HYDROXYCOLECALCIFEROL 24 HYDROXYLASE; ANTINEOPLASTIC AGENT; CYTOCHROME P450; KETOCONAZOLE; KETONE DERIVATIVE; KIDNEY ENZYME; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; IC 50; INHIBITION KINETICS; KIDNEY; MITOCHONDRION;

CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MOLECULAR STRUCTURE; STEROID HYDROXYLASES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRALONES;

EID: 5144222591     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.08.040     Document Type: Article

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