Synthesis and biological properties of 2-methylene-19-nor-25-dehydro-1α-hydroxyvitamin D3-26,23-lactones-weak agonists

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 18, 2008, Pages 8563-8573

  Chiellini, Grazia ^a   Grzywacz, Pawel ^a   Plum, Lori A ^a   Barycki, Rafal ^a   Clagett Dame, Margaret ^a   DeLuca, Hector F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Antagonists; Calcemic activity; Transcription activity; Vitamin D

Indexed keywords

2 METHYLENE 19 NOR 25 DEHYDRO 1ALPHA HYDROXYVITAMIN D3 26,23 LACTONE; AD 47; CALCITRIOL; CALCITRIOL DERIVATIVE; LACTONE DERIVATIVE; OU 72; TEI 9647; TEI 9648; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR; ZK 168281;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; BONE CELL; CALCIUM BLOOD LEVEL; CELL DIFFERENTIATION; CELL STRAIN HL 60; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; STEREOCHEMISTRY; VITAMIN D DEFICIENCY;

ALDEHYDES; ALLYL COMPOUNDS; ANIMALS; BINDING SITES; CALCITRIOL; LACTONES; MALE; METHACRYLATES; PHOSPHINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 51449093060     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.011     Document Type: Article

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