New 2-alkylidene 1α,25-dihydroxy-19-norvitamin D3 analogues of high intestinal activity: Synthesis and biological evaluation of 2-(3′-alkoxypropylidene) and 2-(3′-hydroxypropylidene) derivatives

Journal of Medicinal Chemistry

Volumn 49, Issue 10, 2006, Pages 2909-2920

  Glebocka, Agnieszka ^a,b   Sicinski, Rafal R ^a,b   Plum, Lori A ^a   Clagett Dame, Margaret ^a   DeLuca, Hector F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

1ALPHA,25 DIHYDROXY 19 NORVITAMIN D3 DERIVATIVE; 2 (3' HYDROXY)PROPYLIDENE DERIVATIVE; 3' (METHOXYMETHOXY)PROPYLIDENE DERIVATIVE; ALKENE; COLECALCIFEROL DERIVATIVE; CYCLOHEXANONE DERIVATIVE; LACTONE DERIVATIVE; PHOSPHINE OXIDE DERIVATIVE; QUINIC ACID; SULFONE; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM MOBILIZATION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORNER REACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE ABSORPTION; ISOMER; MALE; MELTING POINT; MOLECULAR MODEL; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RECEPTOR AFFINITY; WITTIG REACTION;

ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; CALCITRIOL; CALCIUM; CELL DIFFERENTIATION; CELL LINE, TUMOR; HUMANS; INTESTINAL MUCOSA; LIGANDS; MICE; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RATS; RECEPTORS, CALCITRIOL; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 33646717173     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051082a     Document Type: Article

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