New 1α,25-dihydroxy-19-norvitamin D3 compounds of high biological activity: Synthesis and biological evaluation of 2-hydroxymethyl, 2-methyl, and 2-methylene analogues

Journal of Medicinal Chemistry

Volumn 41, Issue 23, 1998, Pages 4662-4674

  Sicinski, Rafal R ^a,b   Prahl, Jean M ^a   Smith, Connie M ^a   Deluca, Hector F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

1ALPHA, 25 DIHYDROXY 19 NORVITAMIN D3 DERIVATIVE; CALCITRIOL DERIVATIVE; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; 1,25 DIHYDROXY 19 NORVITAMIN D3; 1,25-DIHYDROXY-19-NORVITAMIN D3; CALCITRIOL; CALCITRIOL RECEPTOR; CALCIUM; DRUG DERIVATIVE;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG CONFORMATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING COMPETITION; BONE; CALCIUM INTAKE; CELL LINE; CHEMISTRY; CONFORMATION; DRUG EFFECT; IN VITRO STUDY; INTESTINE; MALE; METABOLISM; RAT; SWINE; SYNTHESIS;

ANIMALS; BINDING, COMPETITIVE; BONE AND BONES; CALCITRIOL; CALCIUM; CALCIUM, DIETARY; CELL DIFFERENTIATION; CELL LINE; HUMANS; INTESTINES; MALE; MOLECULAR CONFORMATION; RATS; RECEPTORS, CALCITRIOL; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0032487676     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9802618     Document Type: Article

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