Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 10, 2005, Pages 3487-3495

  Vintém, Ana Paula B ^a,d   Price, Nigel T ^b   Silverman, Richard B ^c   Ramsay, Rona R ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b HANNAH RESEARCH INSTITUTE   (United Kingdom)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UNIVERSITY OF AVEIRO   (Portugal)

Author keywords

Allosteric effect; Chemical mechanism; Cyclopropylamine; Cysteine modification; Monoamine oxidase

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME PURIFICATION; GENE MUTATION; KINETICS; NONHUMAN; OXIDATION REDUCTION REACTION; SURFACE PROPERTY; WILD TYPE;

GYMNOMYZA SAMOENSIS;

EID: 17444368018     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.02.061     Document Type: Article

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