Pentacycloundecane derived hydroxy acid peptides: A new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease inhibitors

Bioorganic Chemistry

Volumn 40, Issue 1, 2012, Pages 19-29

  Karpoormath, Rajshekhar ^a   Sayed, Yasien ^b   Govender, Patrick ^a   Govender, Thavendran ^a   Kruger, Hendrik G ^a   Soliman, Mahmoud E S ^c   Maguire, Glenn E M ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c Zagazig University   (Egypt)

Author keywords

5 Hydrozxy 4 oxahexacyclo 5.4.1.0 2,6.0 3,10.0 5,9.0 8,11 dodecane peptides; Docking; HIV protease inhibitor; HIV 1 wild type C SA protease; Inhibitory concentration (IC 50); Molecular dynamics; PCU derived peptides; Transition state analogs

Indexed keywords

AMPRENAVIR; HYDROXYACID; PENTACYCLOUNDECANE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; ENZYME ACTIVATION; ETHER, ETHYL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; HYDROXY ACIDS; MOLECULAR DYNAMICS SIMULATION; PEPTIDES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84855875382     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2011.08.002     Document Type: Article

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