Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol- containing transition-state mimic

Journal of Medicinal Chemistry

Volumn 51, Issue 4, 2008, Pages 1053-1057

  Wu, Xiongyu ^a   Öhrngren, Per ^a   Ekegren, Jenny K ^a   Unge, Johan ^a   Unge, Torsten ^a   Wallberg, Hans ^b   Samuelsson, Bertil ^b   Hallberg, Anders ^a   Larhed, Mats ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MEDIVIR AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1 [N' [4 HYDROXY 4 (2 HYDROXY INDAN 1 YL CARBAMOYL) 5 PHENYLPENTYL] N' (4 PYRIDIN 4 YLBENZYL)HYDRAZINOCARBANOYL] 2,2 DIMETHYLPROPYL]CARBAMIC ACID METHYL ESTER; ALCOHOL DERIVATIVE; CARBON; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; X RAY ANALYSIS;

ALCOHOLS; BINDING SITES; CARBAMATES; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; HYDRAZINES; IMIDAZOLES; MODELS, MOLECULAR; MOLECULAR MIMICRY; OXADIAZOLES; PYRIDINES; STEREOISOMERISM;

EID: 39749165062     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070680h     Document Type: Article

References (29)