The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for δ/μ opioid receptor agonists and neurokinin 1 receptor antagonists

Journal of Medicinal Chemistry

Volumn 51, Issue 20, 2008, Pages 6334-6347

  Yamamoto, Takashi ^a   Nair, Padma ^a   Jacobsen, Neil E ^a   Davis, Peg ^b   Ma, Shou Wu ^b   Navratilova, Edita ^b   Moye, Sharif ^b   Lai, Josephine ^b   Yamamura, Henry I ^b   Vanderah, Todd W ^b   Porreca, Frank ^b   Hruby, Victor J ^a  

^a University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIPHALIN; DELTA OPIATE RECEPTOR AGONIST; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; METENKEPHALIN; MU OPIATE RECEPTOR AGONIST; NEUROKININ 1 RECEPTOR ANTAGONIST; PEPTIDE DERIVATIVE; SUBSTANCE P; TYROSYL DEXTRO ALANYLGLYCYLPHENYLALANYLMETHIONYLPROLYLLEUCYLTRYPTOPHAN 3',5' (BISTRIFLUOROMETHYL)BENZYL ESTER; TYROSYL DEXTRO ALANYLGLYCYLPHENYLALANYLMETHIONYLPROLYLLEUCYLTRYPTOPHAN 3',5' (BISTRIFLUOROMETHYL)BENZYLAMIDE; TYROSYL DEXTRO ALANYLGLYCYLPHENYLALANYLMETHIONYLPROLYLLEUCYLTRYPTOPHAN BENZYLAMIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG RECEPTOR BINDING; GUINEA PIG; ILEUM; MALE; MICELLE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; STRUCTURE ACTIVITY RELATION; VAS DEFERENS;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; LIGANDS; MICELLES; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OPIOID PEPTIDES; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, NEUROKININ-1; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; SPECTROMETRY, FLUORESCENCE;

EID: 54549088960     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800389v     Document Type: Article

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