Analysis of the S3 and S3′ subsite specificities of feline immunodeficiency virus (FIV) protease: Development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 3, 1998, Pages 939-944

  Lee, Taekyu ^a   Laco, Gary S ^a,b   Torbett, Bruce E ^a   Fox, Howard S ^a   Lerner, Danica L ^a   Elder, John H ^a   Wong, Chi Huey ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 DIBENZYL 2,3 DIOL; 4,7 DIBENZYL 2,3,4,5,6,7 HEXAHYDRO 5,6 DIHYDROXY 1,3 BIS[4 (HYDROXYMETHYL)BENZYL] 2H 1,3 DIAZEPIN 2 ONE; HOE 793; PROTEINASE INHIBITOR; SAQUINAVIR; UNCLASSIFIED DRUG; VIRUS ENZYME;

AMINO ACID SEQUENCE; BINDING SITE; CONFERENCE PAPER; DRUG PROTEIN BINDING; ENZYME CONFORMATION; ENZYME SPECIFICITY; FELINE IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEINASE INHIBITION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; VIRUS INHIBITION;

ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CATS; CELL LINE; DISEASE MODELS, ANIMAL; DRUG DESIGN; FELINE ACQUIRED IMMUNODEFICIENCY SYNDROME; HIV INFECTIONS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; IMMUNODEFICIENCY VIRUS, FELINE; KINETICS; PROTEASE INHIBITORS; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP;

FELIDAE; FELINE IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0032477910     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.3.939     Document Type: Article

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