Dendrimer-based multivalent methotrexates as dual acting nanoconjugates for cancer cell targeting

European Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2012, Pages 560-572

  Li, Ming Hsin ^a,b   Choi, Seok Ki ^a   Thomas, Thommey P ^a   Desai, Ankur ^a   Lee, Kyung Hoon ^a,b   Kotlyar, Alina ^a   Banaszak Holl, Mark M ^a,b   Baker Jr , James R ^a,b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Dual activity; Folate receptor; Methotrexate; Multivalent binding; Poly(amidoamine) dendrimer; Targeted drug delivery

Indexed keywords

ANTINEOPLASTIC AGENT; DENDRIMER; DIHYDROFOLATE REDUCTASE; FOLATE RECEPTOR; METHOTREXATE DERIVATIVE; MULTIVALENT METHOTREXATE; NANOCONJUGATE; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER CELL DESTRUCTION; CARBON NUCLEAR MAGNETIC RESONANCE; CYTOTOXICITY; DISSOCIATION CONSTANT; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; MOLECULAR DYNAMICS; MOLECULARLY TARGETED THERAPY; PROTON NUCLEAR MAGNETIC RESONANCE; SIMULATION; SURFACE PLASMON RESONANCE;

ANTINEOPLASTIC AGENTS; DENDRIMERS; FOLIC ACID ANTAGONISTS; HUMANS; KB CELLS; METHOTREXATE; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; NANOCONJUGATES; SURFACE PLASMON RESONANCE; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84855801985     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.11.027     Document Type: Article

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