Variants of human dihydrofolate reductase with substitutions at Leucine-22: Effect on catalytic and inhibitor binding properties

Molecular Pharmacology

Volumn 49, Issue 3, 1996, Pages 430-437

  Ercikan Abali, Emine A ^b   Waltham, Mark C ^a   Dicker, Adam P ^a   Schweitzer, Barry I ^a   Gritsman, Helena ^a   Banerjee, Debabrata ^a   Bertino, Joseph R ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPTERIN; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; METHOTREXATE; MUTANT PROTEIN; PIRITREXIM; TRIMETREXATE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHO CELL; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITOR INTERACTION; ENZYME KINETICS; HUMAN; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; CHO CELLS; CRICETINAE; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMANS; ISOLEUCINE; KINETICS; LEUCINE; METHOTREXATE; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; VARIATION (GENETICS);

EID: 0029963930     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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