Synthesis and functional evaluation of DNA-assembled polyamidoamine dendrimer clusters for cancer cell-specific targeting

Chemistry and Biology

Volumn 12, Issue 1, 2005, Pages 35-43

  Choi, Youngseon ^a,b   Thomas, Thommey ^b   Kotlyar, Alina ^b   Islam, Mohammad T ^b   Baker Jr , James R ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CELL SURFACE RECEPTOR; COMPLEMENTARY DNA; FLUORESCEIN; FOLATE BINDING PROTEIN; FOLATE-BINDING PROTEIN; FOLIC ACID; OLIGONUCLEOTIDE; PHOSPHATE; POLYAMINE;

ARTICLE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; EVALUATION; HUMAN; METABOLISM; MOLECULAR WEIGHT; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY; SYNTHESIS; TUMOR CELL LINE;

CARRIER PROTEINS; CELL LINE, TUMOR; DNA, COMPLEMENTARY; DRUG DESIGN; EVALUATION STUDIES; FLUORESCEIN; FOLIC ACID; HUMANS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; OLIGONUCLEOTIDES; PHOSPHATES; POLYAMINES; RECEPTORS, CELL SURFACE; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

EID: 12344295674     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2004.10.016     Document Type: Article

References (30)

1. J.R. Baker, A. Quintana, L.T. Piehler, M.M.B. Holl, D.A. Tomalia, and E. Raczka Synthesis and testing of anti-cancer therapeutic nanodevices Biomed. Microdevices 3 2001 61 69
2. E.C. Wiener, S. Konda, A. Shadron, M. Brechbiel, and O. Gansow Targeting dendrimer-chelates to tumors and tumor cells expressing the high-affinity folate receptor Invest. Radiol. 32 1997 748 754
3. J.F. Kukowska-Latallo, A.U. Bielinska, J. Johnson, R. Spindler, D.A. Tomalia, and J.R. Baker Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers Proc. Natl. Acad. Sci. USA 93 1996 4897 4902
4. J.J. Landers, Z.Y. Cao, I. Lee, L.T. Piehler, P.P. Myc, A. Myc, T. Hamouda, A.T. Galecki, and J.R. Baker Prevention of influenza pneumonitis by sialic acid-conjugated dendritic polymers J. Infect. Dis. 186 2002 1222 1230
5. A. Quintana, E. Raczka, L.T. Piehler, I. Lee, A. Myc, I. Majoros, A.K. Patri, T. Thomas, J. Mule, and J.R. Baker Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor Pharm. Res. 19 2002 1310 1316
6. K. Kono, M.J. Liu, and J.M.J. Frechet Design of dendritic macromolecules containing folate or methotrexate residues Bioconjug. Chem. 10 1999 1115 1121
7. Y.S. Choi, A. Mecke, B.G. Orr, M.M.B. Holl, and J.R. Baker DNA-directed synthesis of generation 7 and 5 PAMAM dendrimer nanoclusters Nano Lett. 4 2004 391 397
8. C.M. Niemeyer, T. Sano, C.L. Smith, and C.R. Cantor Oligonucleotide- directed self-assembly of proteins - semisynthetic DNA streptavidin hybrid molecules as connectors for the generation of macroscopic arrays and the construction of supramolecular bioconjugates Nucleic Acids Res. 22 1994 5530 5539
9. A.P. Alivisatos, K.P. Johnsson, X.G. Peng, T.E. Wilson, C.J. Loweth, M.P. Bruchez, and P.G. Schultz Organization of 'nanocrystal molecules' using DNA Nature 382 1996 609 611
10. C.A. Mirkin, R.L. Letsinger, R.C. Mucic, and J.J. Storhoff A DNA-based method for rationally assembling nanoparticles into macroscopic materials Nature 382 1996 607 609
11. F.W. Zeng, and S.C. Zimmerman Dendrimers in supramolecular chemistry: from molecular recognition to self-assembly Chem. Rev. 97 1997 1681 1712
12. I. Majoros, K. Balasz, S. Wohler, T. Bull, and J.R. Baker Acetylation of poly(amidoamine) dendrimers Macromolecules 36 2003 5526 5529
13. D.A. Tomalia, A.M. Naylor, and W.A. Goddard Starburst dendrimers - molecular-level control of size, shape, surface-chemistry, topology, and flexibility from atoms to macroscopic matter Angew. Chem. Int. Ed. Engl. 29 1990 138 175
14. G.J. Kallos, D.A. Tomalia, D.M. Hedstrand, S. Lewis, and J. Zhou Molecular-weight determination of a polyamidoamine starburst polymer by electrospray ionization mass-spectrometry Rapid Commun. Mass Spectrom. 5 1991 383 386
15. J. Peterson, V. Allikmaa, J. Subbi, T. Pehk, and M. Lopp Structural deviations in poly(amidoamine) dendrimers: a MALDI-TOF MS analysis Eur. Polym. J. 39 2003 33 42
16. J.J. Storhoff, and C.A. Mirkin Programmed materials synthesis with DNA Chem. Rev. 99 1999 1849 1862
17. C.M. Niemeyer DNA as a material for nanotechnology Angew. Chem. Int. Ed. Engl. 36 1997 585 587
18. R. Elghanian, J.J. Storhoff, R.C. Mucic, R.L. Letsinger, and C.A. Mirkin Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles Science 277 1997 1078 1081
19. J.M. Nam, C.S. Thaxton, and C.A. Mirkin Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins Science 301 2003 1884 1886
20. P. Alivisatos The use of nanocrystals in biological detection Nat. Biotechnol. 22 2004 47 52
21. S.A. Bell, M.E. McLean, S.K. Oh, S.E. Tichy, W. Zhang, R.M. Corn, R.M. Crooks, and E.E. Simanek Synthesis and characterization of covalently linked single-stranded DNA oligonucleotide-dendron conjugates Bioconjug. Chem. 14 2003 488 493
22. C.R. DeMattei, B.H. Huang, and D.A. Tomalia Designed dendrimer syntheses by self-assembly of single-site, ssDNA functionalized dendrons Nano Lett. 4 2004 771 777
23. B.C.F. Chu, G.M. Wahl, and L.E. Orgel Derivatization of unprotected polynucleotides Nucleic Acids Res. 11 1983 6513 6529
24. N. Tomioka, D. Takasu, T. Takahashi, and T. Aida Electrostatic assembly of dendrimer electrolytes: negatively and positively charged dendrimer porphyrins Angew. Chem. Int. Ed. Engl. 37 1998 1531 1534
25. C.P. Leamon, and P.S. Low Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis Proc. Natl. Acad. Sci. USA 88 1991 5572 5576
26. P. Garin-Chesa, I. Campbell, P.E. Saigo, J.L. Lewis, L.J. Old, and W.J. Rettig Trophoblast and ovarian-cancer antigen-Lk26. Sensitivity and specificity in immunopathology and molecular identification as a folate-binding protein Am. J. Pathol. 142 1993 557 567
27. J.F. Ross, P.K. Chaudhuri, and M. Ratnam Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications Cancer 73 1994 2432 2443
28. S.D. Weitman, R.H. Lark, L.R. Coney, D.W. Fort, V. Frasca, V.R. Zurawski, and B.A. Kamen Distribution of the folate receptor Gp38 in normal and malignant cell lines and tissues Cancer Res. 52 1992 3396 3401
29. I.G. Campbell, T.A. Jones, W.D. Foulkes, and J. Trowsdale Folate-binding protein is a marker for ovarian cancer Cancer Res. 51 1991 5329 5338
30. Y.J. Lu, and P.S. Low Folate-mediated delivery of macromolecular anticancer therapeutic agents Adv. Drug Deliv. Rev. 54 2002 675 693