Understanding the role of Leu22 variants in methotrexate resistance: Comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH

Acta Crystallographica Section D: Biological Crystallography

Volumn 61, Issue 2, 2005, Pages 147-155

  Cody, Vivian ^a   Luft, Joe R ^a   Pangborn, Walt ^a  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DIHYDROFOLATE REDUCTASE; LEUCINE; METHOTREXATE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG RESISTANCE; HUMAN; MOLECULAR GENETICS; MOUSE; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE; HUMANS; LEUCINE; METHOTREXATE; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NADP; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 21444435324     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444904030422     Document Type: Article

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