Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

European Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2009, Pages 1900-1912

  Dallavalle, Sabrina ^a   Cincinelli, Raffaella ^a   Nannei, Raffaella ^a   Merlini, Lucio ^a   Morini, Gabriella ^b   Penco, Sergio ^c   Pisano, Claudio ^c   Vesci, Loredana ^c   Barbarino, Marcella ^c   Zuco, Valentina ^d   De Cesare, Michelandrea ^d   Zunino, Franco ^d  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF GASTRONOMIC SCIENCES   (Italy)

^c Sigma Tau SpA   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Antiproliferative activity; Histone deacetylase; Synthesis

Indexed keywords

5 (BIPHENYL 4 YL)PENTANOIC ACID N HYDROXYAMIDE; 5 BIPHENYL 4 YL PENTA 2,4 DIENOIC ACID N HYDROXYAMIDE; ALPHA TUBULIN; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITOR; ISOENZYME; N HYDROXY 3 (4' CYANOBIPHENYL 4 YL)ACRYLAMIDE; N HYDROXY 3 (4' HYDROXYBIPHENYL 4 YL)ACRYLAMIDE; N HYDROXY 3 (4' HYDROXYBIPHENYL 4 YL)PROPIONAMIDE; N HYDROXY 3 (4' METHOXYBIPHENYL 4 YL)ACRYLAMIDE; N HYDROXY 3 [4 (4 HYDROXYPHENYL)CYCLOHEXYL]ACRYLAMIDE; N HYDROXY 3 [4 (4 HYDROXYPHENYL)CYCLOHEXYL]PROPIONAMIDE; N HYDROXY 3 [4' HYDROXYBIPHENYL 3 YL]ACRYLAMIDE; N HYDROXY 3 [4' HYDROXYMETHYLBIPHENYL 4 YL]ACRYLAMIDE; PROTEIN P53; UNCLASSIFIED DRUG; VORINOSTAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLON CARCINOMA; CONTROLLED STUDY; DRUG ACETYLATION; DRUG BINDING SITE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CARCINOMA; MOLECULAR DOCKING; MOUSE; NONHUMAN; OVARY CARCINOMA;

ACETYLATION; APOPTOSIS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; ENZYME INHIBITORS; FEMALE; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; OVARIAN NEOPLASMS; PROTEIN BINDING; TUBULIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 62749154929     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.11.005     Document Type: Article

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