메뉴 건너뛰기




Volumn 2, Issue 1, 2011, Pages

Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CADHERIN 23; CALCIUM ION; FASCIN; ION CHANNEL; MEPROBAMATE; MYOSIN I; MYOSIN VI; MYOSIN VIIA;

EID: 84855687554     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms1533     Document Type: Review
Times cited : (70)

References (133)
  • 1
    • 38449111852 scopus 로고    scopus 로고
    • Mechanotransduction: Touch and feel at the molecular level as modeled in Caenorhabditis elegans
    • DOI 10.1007/s12035-007-8009-5
    • Bianchi, L. Mechanotransduction: touch and feel at the molecular level as modeled in Caenorhabditis elegans. Mol. Neurobiol. 36, 254-271 (2007). (Pubitemid 351360340)
    • (2007) Molecular Neurobiology , vol.36 , Issue.3 , pp. 254-271
    • Bianchi, L.1
  • 2
    • 66749156456 scopus 로고    scopus 로고
    • Linking genes underlying deafness to hair-bundle development and function
    • Petit, C. & Richardson, G. P. Linking genes underlying deafness to hair-bundle development and function. Nat. Neurosci. 12, 703-710 (2009).
    • (2009) Nat. Neurosci. , vol.12 , pp. 703-710
    • Petit, C.1    Richardson, G.P.2
  • 3
    • 0022162342 scopus 로고
    • The cellular basis of hearing: The biophysics of hair cells
    • Hudspeth, A. J. The cellular basis of hearing: the biophysics of hair cells. Science 230, 745-752 (1985). (Pubitemid 16193962)
    • (1985) Science , vol.230 , Issue.4727 , pp. 745-752
    • Hudspeth, A.J.1
  • 4
    • 0019732325 scopus 로고
    • Directional sensitivity of individual vertebrate hair cells to controlled deflection of their hair bundles
    • Shotwell, S. L., Jacobs, R. & Hudspeth, A. J. Directional sensitivity of individual vertebrate hair cells to controlled deflection of their hair bundles. Ann. N Y Acad. Sci. 374, 1-10 (1981). (Pubitemid 12214038)
    • (1981) Annals of the New York Academy of Sciences , vol.374 , pp. 1-10
    • Shotwell, S.L.1    Jacobs, R.2    Hudspeth, A.J.3
  • 5
    • 0021179678 scopus 로고
    • Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction
    • DOI 10.1016/0378-5955(84)90041-8
    • Pickles, J. O., Comis, S. D. & Osborne, M. P. Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction. Hear. Res. 15, 103-112 (1984). (Pubitemid 14068925)
    • (1984) Hearing Research , vol.15 , Issue.2 , pp. 103-112
    • Pickles, J.O.1    Comis, S.D.2    Osborne, M.P.3
  • 8
    • 65549128486 scopus 로고    scopus 로고
    • Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging
    • Beurg, M., Fettiplace, R., Nam, J. H. & Ricci, A. J. Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging. Nat. Neurosci. 12, 553-558 (2009).
    • (2009) Nat. Neurosci. , vol.12 , pp. 553-558
    • Beurg, M.1    Fettiplace, R.2    Nam, J.H.3    Ricci, A.J.4
  • 10
    • 77956125583 scopus 로고    scopus 로고
    • Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15
    • Lelli, A., Kazmierczak, P., Kawashima, Y., Muller, U. & Holt, J. R. Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15. J. Neurosci. 30, 11259-11269 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 11259-11269
    • Lelli, A.1    Kazmierczak, P.2    Kawashima, Y.3    Muller, U.4    Holt, J.R.5
  • 11
    • 0026326113 scopus 로고
    • Tip-link integrity and mechanical transduction in vertebrate hair cells
    • Assad, J. A., Shepherd, G. M. & Corey, D. P. Tip-link integrity and mechanical transduction in vertebrate hair cells. Neuron 7, 985-994 (1991).
    • (1991) Neuron , vol.7 , pp. 985-994
    • Assad, J.A.1    Shepherd, G.M.2    Corey, D.P.3
  • 12
    • 7444253983 scopus 로고    scopus 로고
    • The MinK-related peptides
    • DOI 10.1016/j.neuropharm.2004.06.018, PII S0028390804001716
    • McCrossan, Z. A. & Abbott, G. W. The MinK-related peptides. Neuropharmacology 47, 787-821 (2004). (Pubitemid 39440975)
    • (2004) Neuropharmacology , vol.47 , Issue.6 , pp. 787-821
    • McCrossan, Z.A.1    Abbott, G.W.2
  • 13
    • 0034708452 scopus 로고    scopus 로고
    • A Drosophila mechanosensory transduction channel
    • DOI 10.1126/science.287.5461.2229
    • Walker, R. G., Willingham, A. T. & Zuker, C. S. A Drosophila mechanosensory transduction channel. Science 287, 2229-2234 (2000). (Pubitemid 30177021)
    • (2000) Science , vol.287 , Issue.5461 , pp. 2229-2234
    • Walker, R.G.1    Willingham, A.T.2    Zuker, C.S.3
  • 15
    • 0037710542 scopus 로고    scopus 로고
    • NompC TRP channel required for vertebrate sensory hair cell mechanotransduction
    • DOI 10.1126/science.1084370
    • Sidi, S., Friedrich, R. W. & Nicolson, T. NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science 301, 96-99 (2003). (Pubitemid 36801569)
    • (2003) Science , vol.301 , Issue.5629 , pp. 96-99
    • Sidi, S.1    Friedrich, R.W.2    Nicolson, T.3
  • 16
    • 0345967828 scopus 로고    scopus 로고
    • Tonotopic variation in the conductance of the hair cell mechanotransducer channel
    • DOI 10.1016/S0896-6273(03)00721-9
    • Ricci, A. J., Crawford, A. C. & Fettiplace, R. Tonotopic variation in the conductance of the hair cell mechanotransducer channel. Neuron 40, 983-990 (2003). (Pubitemid 37522055)
    • (2003) Neuron , vol.40 , Issue.5 , pp. 983-990
    • Ricci, A.J.1    Crawford, A.C.2    Fettiplace, R.3
  • 17
    • 4444357289 scopus 로고    scopus 로고
    • Probing the pore of the auditory hair cell mechanotransducer channel in turtle
    • DOI 10.1113/jphysiol.2004.061267
    • Farris, H. E., LeBlanc, C. L., Goswami, J. & Ricci, A. J. Probing the pore of the auditory hair cell mechanotransducer channel in turtle. J. Physiol. 558, 769-792 (2004). (Pubitemid 39199104)
    • (2004) Journal of Physiology , vol.558 , Issue.3 , pp. 769-792
    • Farris, H.E.1    LeBlanc, C.L.2    Goswami, J.3    Ricci, A.J.4
  • 18
    • 23944458137 scopus 로고    scopus 로고
    • The transduction channel filter in auditory hair cells
    • DOI 10.1523/JNEUROSCI.1127-05.2005
    • Ricci, A. J., Kennedy, H. J., Crawford, A. C. & Fettiplace, R. The transduction channel filter in auditory hair cells. J. Neurosci. 25, 7831-7839 (2005). (Pubitemid 41208655)
    • (2005) Journal of Neuroscience , vol.25 , Issue.34 , pp. 7831-7839
    • Ricci, A.J.1    Kennedy, H.J.2    Crawford, A.C.3    Fettiplace, R.4
  • 19
    • 0020633119 scopus 로고
    • Kinetics of the receptor current in bullfrog saccular hair cells
    • Corey, D. P. & Hudspeth, A. J. Kinetics of the receptor current in bullfrog saccular hair cells. J. Neurosci. 3, 962-976 (1983). (Pubitemid 13135421)
    • (1983) Journal of Neuroscience , vol.3 , Issue.5 , pp. 962-976
    • Corey, D.P.1    Hudspeth, A.J.2
  • 20
    • 0024002893 scopus 로고
    • Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the bullfrog's saccular hair cell
    • Howard, J. & Hudspeth, A. J. Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the bullfrog's saccular hair cell. Neuron 1, 189-199 (1988).
    • (1988) Neuron , vol.1 , pp. 189-199
    • Howard, J.1    Hudspeth, A.J.2
  • 21
    • 0036138893 scopus 로고    scopus 로고
    • Mechanisms of active hair bundle motion in auditory hair cells
    • Ricci, A. J., Crawford, A. C. & Fettiplace, R. Mechanisms of active hair bundle motion in auditory hair cells. J. Neurosci. 22, 44-52 (2002). (Pubitemid 34033482)
    • (2002) Journal of Neuroscience , vol.22 , Issue.1 , pp. 44-52
    • Ricci, A.J.1    Crawford, A.C.2    Fettiplace, R.3
  • 23
    • 77951892218 scopus 로고    scopus 로고
    • Structural determinants of cadherin-23 function in hearing and deafness
    • Sotomayor, M., Weihofen, W. A., Gaudet, R. & Corey, D. P. Structural determinants of cadherin-23 function in hearing and deafness. Neuron 66, 85-100 (2010).
    • (2010) Neuron , vol.66 , pp. 85-100
    • Sotomayor, M.1    Weihofen, W.A.2    Gaudet, R.3    Corey, D.P.4
  • 24
    • 1842535278 scopus 로고    scopus 로고
    • Hypothesis: A helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors [1]
    • DOI 10.1016/j.cub.2004.02.050, PII S0960982204001423
    • Howard, J. & Bechstedt, S. Hypothesis: a helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors. Curr. Biol. 14, R224-226 (2004). (Pubitemid 38431268)
    • (2004) Current Biology , vol.14 , Issue.6
    • Howard, J.1    Bechstedt, S.2
  • 25
    • 0023415077 scopus 로고
    • Adaptation of mechanoelectrical transduction in hair cells of the bullfrog's sacculus
    • Eatock, R. A., Corey, D. P. & Hudspeth, A. J. Adaptation of mechanoelectrical transduction in hair cells of the bullfrog's sacculus. J. Neurosci. 7, 2821-2836 (1987).
    • (1987) J. Neurosci. , vol.7 , pp. 2821-2836
    • Eatock, R.A.1    Corey, D.P.2    Hudspeth, A.J.3
  • 26
    • 0031008059 scopus 로고    scopus 로고
    • The effects of calcium buffering and cyclic AMP on mechano-electrical transduction in turtle auditory hair cells
    • DOI 10.1111/j.1469-7793.1997.111bo.x
    • Ricci, A. J. & Fettiplace, R. The effects of calcium buffering and cyclic AMP on mechano-electrical transduction in turtle auditory hair cells. J. Physiol. (Lond) 501, 111-124 (1997). (Pubitemid 27230406)
    • (1997) Journal of Physiology , vol.501 , Issue.1 , pp. 111-124
    • Ricci, A.J.1    Fettiplace, R.2
  • 27
    • 0042532277 scopus 로고    scopus 로고
    • Fast adaptation of mechanoelectrical transducer channels in mammalian cochlear hair cells
    • DOI 10.1038/nn1089
    • Kennedy, H. J., Evans, M. G., Crawford, A. C. & Fettiplace, R. Fast adaptation of mechanoelectrical transducer channels in mammalian cochlear hair cells. Nat. Neurosci. 6, 832-836 (2003). (Pubitemid 36929704)
    • (2003) Nature Neuroscience , vol.6 , Issue.8 , pp. 832-836
    • Kennedy, H.J.1    Evans, M.G.2    Crawford, A.C.3    Fettiplace, R.4
  • 28
    • 14544269417 scopus 로고    scopus 로고
    • Force generation by mammalian hair bundles supports a role in cochlear amplification
    • DOI 10.1038/nature03367
    • Kennedy, H. J., Crawford, A. C. & Fettiplace, R. Force generation by mammalian hair bundles supports a role in cochlear amplification. Nature 433, 880-883 (2005). (Pubitemid 40314898)
    • (2005) Nature , vol.433 , Issue.7028 , pp. 880-883
    • Kennedy, H.J.1    Crawford, A.C.2    Fettiplace, R.3
  • 29
    • 16644397827 scopus 로고    scopus 로고
    • The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals
    • DOI 10.1038/nn1362
    • O'Hagan, R., Chalfie, M. & Goodman, M. B. The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nat. Neurosci. 8, 43-50 (2005). (Pubitemid 41236730)
    • (2005) Nature Neuroscience , vol.8 , Issue.1 , pp. 43-50
    • O'Hagan, R.1    Chalfie, M.2    Goodman, M.B.3
  • 30
    • 77953053747 scopus 로고    scopus 로고
    • Adaptive behavior of bacterial mechanosensitive channels is coupled to membrane mechanics
    • Belyy, V., Kamaraju, K., Akitake, B., Anishkin, A. & Sukharev, S. Adaptive behavior of bacterial mechanosensitive channels is coupled to membrane mechanics. J. Gen. Physiol. 135, 641-652 (2010).
    • (2010) J. Gen. Physiol. , vol.135 , pp. 641-652
    • Belyy, V.1    Kamaraju, K.2    Akitake, B.3    Anishkin, A.4    Sukharev, S.5
  • 31
    • 49849096118 scopus 로고    scopus 로고
    • Making an effort to listen: Mechanical amplification in the ear
    • Hudspeth, A. J. Making an effort to listen: mechanical amplification in the ear. Neuron 59, 530-545 (2008).
    • (2008) Neuron , vol.59 , pp. 530-545
    • Hudspeth, A.J.1
  • 32
    • 33845268874 scopus 로고    scopus 로고
    • 2+]
    • DOI 10.1523/JNEUROSCI.3569-06.2006
    • Farris, H. E., Wells, G. B. & Ricci, A. J. Steady-state adaptation of mechanotransduction modulates the resting potential of auditory hair cells, providing an assay for endolymph [Ca2+]. J. Neurosci. 26, 12526-12536 (2006). (Pubitemid 44864517)
    • (2006) Journal of Neuroscience , vol.26 , Issue.48 , pp. 12526-12536
    • Farris, H.E.1    Wells, G.B.2    Ricci, A.J.3
  • 33
    • 79959306372 scopus 로고    scopus 로고
    • Prestin-driven cochlear amplification is not limited by the outer hair cell membrane time constant
    • Johnson, S. L., Beurg, M., Marcotti, W. & Fettiplace, R. Prestin-driven cochlear amplification is not limited by the outer hair cell membrane time constant. Neuron 70, 1143-1154 (2011).
    • (2011) Neuron , vol.70 , pp. 1143-1154
    • Johnson, S.L.1    Beurg, M.2    Marcotti, W.3    Fettiplace, R.4
  • 34
    • 0024804277 scopus 로고
    • Activation and adaptation of transducer currents in turtle hair cells
    • Crawford, A. C., Evans, M. G. & Fettiplace, R. Activation and adaptation of transducer currents in turtle hair cells. J. Physiol. (Lond) 419, 405-434 (1989). (Pubitemid 20012026)
    • (1989) Journal of Physiology , vol.419 , pp. 405-434
    • Crawford, A.C.1    Evans, M.G.2    Fettiplace, R.3
  • 35
    • 0025967552 scopus 로고
    • The actions of calcium on the mechano-electrical transducer current of turtle hair cells
    • Crawford, A. C., Evans, M. G. & Fettiplace, R. The actions of calcium on the mechano-electrical transducer current of turtle hair cells. J. Physiol. (Lond) 434, 369-398 (1991).
    • (1991) J. Physiol. (Lond) , vol.434 , pp. 369-398
    • Crawford, A.C.1    Evans, M.G.2    Fettiplace, R.3
  • 36
    • 0031984135 scopus 로고    scopus 로고
    • Calcium permeation of the turtle hair cell mechanotransducer channel and its relation to the composition of endolymph
    • DOI 10.1111/j.1469-7793.1998.159bx.x
    • Ricci, A. J. & Fettiplace, R. Calcium permeation of the turtle hair cell mechanotransducer channel and its relation to the composition of endolymph [published erratum appears in J. Physiol. (Lond) 1998 Mar 15;507(Pt 3):939]. J. Physiol. (Lond) 506, 159-173 (1998). (Pubitemid 28046044)
    • (1998) Journal of Physiology , vol.506 , Issue.1 , pp. 159-173
    • Ricci, A.J.1    Fettiplace, R.2
  • 37
    • 0021891154 scopus 로고
    • The mechanical properties of ciliary bundles of turtle cochlear hair cells
    • Crawford, A. C. & Fettiplace, R. The mechanical properties of ciliary bundles of turtle cochlear hair cells. J. Physiol. (Lond) 364, 359-379 (1985). (Pubitemid 15067219)
    • (1985) Journal of Physiology , vol.VOL. 364 , pp. 359-379
    • Crawford, A.C.1    Fettiplace, R.2
  • 38
    • 0345227330 scopus 로고
    • Mechanical relaxation of the hair bundle mediates adaptation in mechanoelectrical transduction by the bullfrog's saccular hair cell
    • DOI 10.1073/pnas.84.9.3064
    • Howard, J. & Hudspeth, A. J. Mechanical relaxation of the hair bundle mediates adaptation in mechanoelectrical transduction by the bullfrog's saccular hair cell. Proc. Natl Acad. Sci. USA 84, 3064-3068 (1987). (Pubitemid 17064780)
    • (1987) Proceedings of the National Academy of Sciences of the United States of America , vol.84 , Issue.9 , pp. 3064-3068
    • Howard, J.1    Hudspeth, A.J.2
  • 39
    • 0026666397 scopus 로고
    • An active motor model for adaptation by vertebrate hair cells
    • Assad, J. A. & Corey, D. P. An active motor model for adaptation by vertebrate hair cells. J. Neurosci. 12, 3291-3309 (1992).
    • (1992) J. Neurosci. , vol.12 , pp. 3291-3309
    • Assad, J.A.1    Corey, D.P.2
  • 41
    • 0027439124 scopus 로고
    • Identification of a 120 kd hair-bundle myosin located near stereociliary tips
    • DOI 10.1016/0896-6273(93)90071-X
    • Gillespie, P. G., Wagner, M. C. & Hudspeth, A. J. Identification of a 120 kd hair-bundle myosin located near stereociliary tips. Neuron 11, 581-594 (1993). (Pubitemid 23321769)
    • (1993) Neuron , vol.11 , Issue.4 , pp. 581-594
    • Gillespie, P.G.1    Wagner, M.C.2    Hudspeth, A.J.3
  • 42
    • 0032194948 scopus 로고    scopus 로고
    • Localization of myosin-Iβ near both ends of tip links in frog saccular hair cells
    • Garcia, J. A., Yee, A. G., Gillespie, P. G. & Corey, D. P. Localization of myosin-Ibeta near both ends of tip links in frog saccular hair cells. J. Neurosci. 18, 8637-8647 (1998). (Pubitemid 28491730)
    • (1998) Journal of Neuroscience , vol.18 , Issue.21 , pp. 8637-8647
    • Garcia, J.A.1    Yee, A.G.2    Gillespie, P.G.3    Corey, D.P.4
  • 43
    • 73949146587 scopus 로고    scopus 로고
    • Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells
    • Michalski, N. et al. Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells. Pflugers Arch. 459, 115-130 (2009).
    • (2009) Pflugers Arch. , vol.459 , pp. 115-130
    • Michalski, N.1
  • 46
    • 0029562476 scopus 로고
    • Calcium imaging of single stereocilia in hair cells: Localization of transduction channels at both ends of tip links
    • DOI 10.1016/0896-6273(95)90010-1
    • Denk, W., Holt, J. R., Shepherd, G. M. & Corey, D. P. Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links. Neuron 15, 1311-1321 (1995). (Pubitemid 26005369)
    • (1995) Neuron , vol.15 , Issue.6 , pp. 1311-1321
    • Denk, W.1    Holt, J.R.2    Shepherd, G.M.G.3    Corey, D.P.4
  • 47
    • 0032718959 scopus 로고    scopus 로고
    • Two components of transducer adaptation in auditory hair cells
    • Wu, Y.- C., Ricci, A. J. & Fettiplace, R. Two components of transducer adaptation in auditory hair cells. J. Neurophysiol. 82, 2171-2181 (1999).
    • (1999) J. Neurophysiol. , vol.82 , pp. 2171-2181
    • Wu -, Y.C.1    Ricci, A.J.2    Fettiplace, R.3
  • 48
    • 37249014360 scopus 로고    scopus 로고
    • Stepwise morphological and functional maturation of mechanotransduction in rat outer hair cells
    • DOI 10.1523/JNEUROSCI.2159-07.2007
    • Waguespack, J., Salles, F. T., Kachar, B. & Ricci, A. J. Stepwise morphological and functional maturation of mechanotransduction in rat outer hair cells. J. Neurosci. 27, 13890-13902 (2007). (Pubitemid 350278258)
    • (2007) Journal of Neuroscience , vol.27 , Issue.50 , pp. 13890-13902
    • Waguespack, J.1    Salles, F.T.2    Kachar, B.3    Ricci, A.J.4
  • 49
    • 0034307572 scopus 로고    scopus 로고
    • Active hair bundle motion linked to fast transducer adaptation in auditory hair cells
    • Ricci, A. J., Crawford, A. C. & Fettiplace, R. Active hair bundle motion linked to fast transducer adaptation in auditory hair cells. J. Neurosci. 20, 7131-7142 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 7131-7142
    • Ricci, A.J.1    Crawford, A.C.2    Fettiplace, R.3
  • 50
    • 66349126903 scopus 로고    scopus 로고
    • Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea
    • Lelli, A., Asai, Y., Forge, A., Holt, J. R. & Geleoc, G. S. Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea. J. Neurophysiol. 101, 2961-2973 (2009).
    • (2009) J. Neurophysiol. , vol.101 , pp. 2961-2973
    • Lelli, A.1    Asai, Y.2    Forge, A.3    Holt, J.R.4    Geleoc, G.S.5
  • 52
    • 65249091289 scopus 로고    scopus 로고
    • Fast adaptation and Ca2+ sensitivity of the mechanotransducer require myosin-XVa in inner but not outer cochlear hair cells
    • Stepanyan, R. & Frolenkov, G. I. Fast adaptation and Ca2+ sensitivity of the mechanotransducer require myosin-XVa in inner but not outer cochlear hair cells. J. Neurosci. 29, 4023-4034 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 4023-4034
    • Stepanyan, R.1    Frolenkov, G.I.2
  • 54
    • 79960999113 scopus 로고    scopus 로고
    • Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction
    • Grati, M. & Kachar, B. Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction. Proc. Natl Acad. Sci. USA 108, 11476-11481 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 11476-11481
    • Grati, M.1    Kachar, B.2
  • 55
    • 33750937612 scopus 로고    scopus 로고
    • Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice
    • Phillips, K. R., Tong, S., Goodyear, R., Richardson, G. P. & Cyr, J. L. Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice. J. Neurosci. 26, 10777-10788 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 10777-10788
    • Phillips, K.R.1    Tong, S.2    Goodyear, R.3    Richardson, G.P.4    Cyr, J.L.5
  • 56
    • 5144227109 scopus 로고    scopus 로고
    • Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation
    • DOI 10.1016/j.neuron.2004.09.020, PII S0896627304005781
    • Hirono, M., Denis, C. S., Richardson, G. P. & Gillespie, P. G. Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation. Neuron 44, 309-320 (2004). (Pubitemid 39346254)
    • (2004) Neuron , vol.44 , Issue.2 , pp. 309-320
    • Hirono, M.1    Denis, C.S.2    Richardson, G.P.3    Gillespie, P.G.4
  • 57
    • 0032531844 scopus 로고    scopus 로고
    • The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells
    • Ricci, A. J., Wu, Y. C. & Fettiplace, R. The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells. J. Neurosci. 18, 8261-8277 (1998). (Pubitemid 28465003)
    • (1998) Journal of Neuroscience , vol.18 , Issue.20 , pp. 8261-8277
    • Ricci, A.J.1    Wu, Y.-C.2    Fettiplace, R.3
  • 58
    • 70349448090 scopus 로고    scopus 로고
    • Mechanotransduction by hair cells: Models, molecules, and mechanisms
    • Gillespie, P. G. & Muller, U. Mechanotransduction by hair cells: models, molecules, and mechanisms. Cell 139, 33-44 (2009).
    • (2009) Cell , vol.139 , pp. 33-44
    • Gillespie, P.G.1    Muller, U.2
  • 59
    • 33748892963 scopus 로고    scopus 로고
    • A large-conductance calcium-selective mechanotransducer channel in mammalian cochlear hair cells
    • DOI 10.1523/JNEUROSCI.2188-06.2006
    • Beurg, M., Evans, M. G., Hackney, C. M. & Fettiplace, R. A large-conductance calcium-selective mechanotransducer channel in mammalian cochlear hair cells. J. Neurosci. 26, 10992-11000 (2006). (Pubitemid 44772189)
    • (2006) Journal of Neuroscience , vol.26 , Issue.43 , pp. 10992-11000
    • Beurg, M.1    Evans, M.G.2    Hackney, C.M.3    Fettiplace, R.4
  • 61
    • 0021276455 scopus 로고
    • Studies on hair cells in isolated coils from the guinea pig cochlea
    • Flock, A. F. & Strelioff, D. Studies on hair cells in isolated coils from the guinea pig cochlea. Hear. Res. 15, 11-18 (1984). (Pubitemid 14093323)
    • (1984) Hearing Research , vol.15 , Issue.1 , pp. 11-18
    • Flock, A.1    Strelioff, D.2
  • 62
    • 79959252972 scopus 로고    scopus 로고
    • Forces between clustered stereocilia minimize friction in the ear on a subnanometre scale
    • Kozlov, A. S., Baumgart, J., Risler, T., Versteegh, C. P. & Hudspeth, A. J. Forces between clustered stereocilia minimize friction in the ear on a subnanometre scale. Nature 474, 376-379 (2011).
    • (2011) Nature , vol.474 , pp. 376-379
    • Kozlov, A.S.1    Baumgart, J.2    Risler, T.3    Versteegh, C.P.4    Hudspeth, A.J.5
  • 63
    • 77953269447 scopus 로고    scopus 로고
    • Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing
    • Kitajiri, S. et al. Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell 141, 786-798 (2010).
    • (2010) Cell , vol.141 , pp. 786-798
    • Kitajiri, S.1
  • 64
    • 33646131833 scopus 로고    scopus 로고
    • Ca2+ changes the force sensitivity of the hair-cell transduction channel
    • Cheung, E. L. & Corey, D. P. Ca2+ changes the force sensitivity of the hair-cell transduction channel. Biophys. J. 90, 124-139 (2006).
    • (2006) Biophys. J. , vol.90 , pp. 124-139
    • Cheung, E.L.1    Corey, D.P.2
  • 65
    • 41649107686 scopus 로고    scopus 로고
    • The actions of calcium on hair bundle mechanics in mammalian cochlear hair cells
    • Beurg, M., Nam, J. H., Crawford, A. & Fettiplace, R. The actions of calcium on hair bundle mechanics in mammalian cochlear hair cells. Biophys. J. 94, 2639-2653 (2008).
    • (2008) Biophys. J. , vol.94 , pp. 2639-2653
    • Beurg, M.1    Nam, J.H.2    Crawford, A.3    Fettiplace, R.4
  • 67
    • 37549027947 scopus 로고    scopus 로고
    • Sensory transduction and adaptation in inner and outer hair cells of the mouse auditory system
    • Stauffer, E. A. & Holt, J. R. Sensory transduction and adaptation in inner and outer hair cells of the mouse auditory system. J. Neurophysiol. 98, 3360-3369 (2007).
    • (2007) J. Neurophysiol. , vol.98 , pp. 3360-3369
    • Stauffer, E.A.1    Holt, J.R.2
  • 68
    • 0025071012 scopus 로고
    • Spontaneous and electrically induced movements of ampullary kinocilia and stereovilli
    • Rusch, A. & Thurm, U. Spontaneous and electrically induced movements of ampullary kinocilia and stereovilli. Hear. Res. 48, 247-263 (1990).
    • (1990) Hear. Res. , vol.48 , pp. 247-263
    • Rusch, A.1    Thurm, U.2
  • 69
    • 0038614902 scopus 로고    scopus 로고
    • Spontaneous oscillation by hair bundles of the bullfrog's sacculus
    • Martin, P., Bozovic, D., Choe, Y. & Hudspeth, A. J. Spontaneous oscillation by hair bundles of the bullfrog's sacculus. J. Neurosci. 23, 4533-4548 (2003). (Pubitemid 36706184)
    • (2003) Journal of Neuroscience , vol.23 , Issue.11 , pp. 4533-4548
    • Martin, P.1    Bozovic, D.2    Choe, Y.3    Hudspeth, A.J.4
  • 70
    • 0029050218 scopus 로고
    • The kinocilium of auditory hair cells and evidence for its morphogenetic role during the regeneration of stereocilia and cuticular plates
    • Sobkowicz, H. M., Slapnick, S. M. & August, B. K. The kinocilium of auditory hair cells and evidence for its morphogenetic role during the regeneration of stereocilia and cuticular plates. J. Neurocytol. 24, 633-653 (1995).
    • (1995) J. Neurocytol. , vol.24 , pp. 633-653
    • Sobkowicz, H.M.1    Slapnick, S.M.2    August, B.K.3
  • 71
    • 0026677618 scopus 로고
    • Actin filaments, stereocilia, and hair cells: How cells count and measure
    • Tilney, L. G., Tilney, M. S. & DeRosier, D. J. Actin filaments, stereocilia, and hair cells: how cells count and measure. Annu. Rev. Cell Biol. 8, 257-274 (1992). (Pubitemid 23000998)
    • (1992) Annual Review of Cell Biology , vol.8 , pp. 257-274
    • Tilney, L.G.1    Tilney, M.S.2    DeRosier, D.J.3
  • 72
    • 36048968147 scopus 로고    scopus 로고
    • Shaping the mammalian auditory sensory organ by the planar cell polarity pathway
    • DOI 10.1387/ijdb.072344mk
    • Kelly, M. & Chen, P. Shaping the mammalian auditory sensory organ by the planar cell polarity pathway. Int. J. Dev. Biol. 51, 535-547 (2007). (Pubitemid 350084409)
    • (2007) International Journal of Developmental Biology , vol.51 , Issue.6-7 , pp. 535-547
    • Kelly, M.1    Chen, P.2
  • 73
    • 1642322799 scopus 로고    scopus 로고
    • An actin molecular treadmill and myosins maintain stereocilia functional architecture and self-renewal
    • DOI 10.1083/jcb.200310055
    • Rzadzinska, A. K., Schneider, M. E., Davies, C., Riordan, G. P. & Kachar, B. An actin molecular treadmill and myosins maintain stereocilia functional architecture and self-renewal. J. Cell Biol. 164, 887-897 (2004). (Pubitemid 38366900)
    • (2004) Journal of Cell Biology , vol.164 , Issue.6 , pp. 887-897
    • Rzadzinska, A.K.1    Schneider, M.E.2    Davies, C.3    Riordan, G.P.4    Kachar, B.5
  • 74
    • 0028075559 scopus 로고
    • Postnatal development of the hamster cochlea. II. Growth and differentiation of stereocilia bundles
    • DOI 10.1002/cne.903500204
    • Kaltenbach, J. A., Falzarano, P. R. & Simpson, T. H. Postnatal development of the hamster cochlea. II. Growth and differentiation of stereocilia bundles. J. Comp. Neurol. 350, 187-198 (1994). (Pubitemid 24346678)
    • (1994) Journal of Comparative Neurology , vol.350 , Issue.2 , pp. 187-198
    • Kaltenbach, J.A.1    Falzarano, P.R.2    Simpson, T.H.3
  • 75
    • 0034604349 scopus 로고    scopus 로고
    • The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins
    • Zheng, L. et al. The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins. Cell 102, 377-385 (2000).
    • (2000) Cell , vol.102 , pp. 377-385
    • Zheng, L.1
  • 76
    • 16844368993 scopus 로고    scopus 로고
    • Development and properties of stereociliary link types in hair cells of the mouse cochlea
    • DOI 10.1002/cne.20513
    • Goodyear, R. J., Marcotti, W., Kros, C. J. & Richardson, G. P. Development and properties of stereociliary link types in hair cells of the mouse cochlea. J. Comp. Neurol. 485, 75-85 (2005). (Pubitemid 40488087)
    • (2005) Journal of Comparative Neurology , vol.485 , Issue.1 , pp. 75-85
    • Goodyear, R.J.1    Marcotti, W.2    Kros, C.J.3    Richardson, G.P.4
  • 78
    • 78650229876 scopus 로고    scopus 로고
    • Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane
    • Verpy, E. et al. Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane. J. Comp. Neurol. 519, 194-210 (2011).
    • (2011) J. Comp. Neurol. , vol.519 , pp. 194-210
    • Verpy, E.1
  • 79
    • 0344629711 scopus 로고    scopus 로고
    • Developmental assembly of transduction apparatus in chick basilar papilla
    • Si, F., Brodie, H., Gillespie, P. G., Vazquez, A. E. & Yamoah, E. N. Developmental assembly of transduction apparatus in chick basilar papilla. J. Neurosci. 23, 10815-10826 (2003). (Pubitemid 37499688)
    • (2003) Journal of Neuroscience , vol.23 , Issue.34 , pp. 10815-10826
    • Si, F.1    Brodie, H.2    Gillespie, P.G.3    Vazquez, A.E.4    Yamoah, E.N.5
  • 80
    • 0141765843 scopus 로고    scopus 로고
    • Developmental acquisition of sensory transduction in hair cells of the mouse inner ear
    • DOI 10.1038/nn1120
    • Geleoc, G. S. & Holt, J. R. Developmental acquisition of sensory transduction in hair cells of the mouse inner ear. Nat. Neurosci. 6, 1019-1020 (2003). (Pubitemid 37186191)
    • (2003) Nature Neuroscience , vol.6 , Issue.10 , pp. 1019-1020
    • Geleoc, G.S.G.1    Holt, J.R.2
  • 81
    • 44449102085 scopus 로고    scopus 로고
    • A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth
    • DOI 10.1242/dev.012922
    • Lefevre, G. et al. A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth. Development 135, 1427-1437 (2008). (Pubitemid 351753633)
    • (2008) Development , vol.135 , Issue.8 , pp. 1427-1437
    • Lefevre, G.1    Michel, V.2    Weil, D.3    Lepelletier, L.4    Bizard, E.5    Wolfrum, U.6    Hardelin, J.-P.7    Petit, C.8
  • 82
    • 54849439728 scopus 로고    scopus 로고
    • CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes
    • Yip, M. F. et al. CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes. Cell Metab. 8, 384-398 (2008).
    • (2008) Cell Metab. , vol.8 , pp. 384-398
    • Yip, M.F.1
  • 83
    • 33644537736 scopus 로고    scopus 로고
    • Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells
    • Senften, M. et al. Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. J. Neurosci. 26, 2060-2071 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 2060-2071
    • Senften, M.1
  • 84
    • 70349622812 scopus 로고    scopus 로고
    • MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear
    • Rzadzinska, A. K., Nevalainen, E. M., Prosser, H. M., Lappalainen, P. & Steel, K. P. MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear. PLoS ONE 4, e7097 (2009).
    • (2009) PLoS ONE , vol.4
    • Rzadzinska, A.K.1    Nevalainen, E.M.2    Prosser, H.M.3    Lappalainen, P.4    Steel, K.P.5
  • 85
    • 46849113840 scopus 로고    scopus 로고
    • Dynamic compartmentalization of protein tyrosine phosphatase receptor Q at the proximal end of stereocilia: Implication of myosin Vi-based transport
    • DOI 10.1002/cm.20275
    • Sakaguchi, H. et al. Dynamic compartmentalization of protein tyrosine phosphatase receptor Q at the proximal end of stereocilia: implication of myosin VI-based transport. Cell Motil. Cytoskeleton 65, 528-538 (2008). (Pubitemid 351956381)
    • (2008) Cell Motility and the Cytoskeleton , vol.65 , Issue.7 , pp. 528-538
    • Sakaguchi, H.1    Tokita, J.2    Naoz, M.3    Bowen-Pope, D.4    Gov, N.S.5    Kachar, B.6
  • 89
    • 0026802046 scopus 로고
    • A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites
    • Sato, N., Funayama, N., Nagafuchi, A., Yonemura, S. & Tsukita, S. A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. J. Cell Sci. 103(Part 1), 131-143 (1992).
    • (1992) J. Cell Sci. , vol.103 , Issue.PART 1 , pp. 131-143
    • Sato, N.1    Funayama, N.2    Nagafuchi, A.3    Yonemura, S.4    Tsukita, S.5
  • 91
    • 72849115649 scopus 로고    scopus 로고
    • Twinfilin 2 regulates actin filament lengths in cochlear stereocilia
    • Peng, A. W., Belyantseva, I. A., Hsu, P. D., Friedman, T. B. & Heller, S. Twinfilin 2 regulates actin filament lengths in cochlear stereocilia. J. Neurosci. 29, 15083-15088 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 15083-15088
    • Peng, A.W.1    Belyantseva, I.A.2    Hsu, P.D.3    Friedman, T.B.4    Heller, S.5
  • 92
    • 79151470659 scopus 로고    scopus 로고
    • Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8
    • Manor, U. et al. Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8. Curr. Biol. 21, 167-172 (2011).
    • (2011) Curr. Biol. , vol.21 , pp. 167-172
    • Manor, U.1
  • 93
    • 79955488611 scopus 로고    scopus 로고
    • Eps8 regulates hair bundle length and functional maturation of Mammalian auditory hair cells
    • Zampini, V. et al. Eps8 regulates hair bundle length and functional maturation of Mammalian auditory hair cells. PLoS Biol. 9, e1001048 (2011).
    • (2011) PLoS Biol. , vol.9
    • Zampini, V.1
  • 94
    • 33846551830 scopus 로고    scopus 로고
    • Hair bundles are specialized for ATP delivery via creatine kinase
    • Shin, J. B. et al. Hair bundles are specialized for ATP delivery via creatine kinase. Neuron 53, 371-386 (2007).
    • (2007) Neuron , vol.53 , pp. 371-386
    • Shin, J.B.1
  • 95
    • 70349560369 scopus 로고    scopus 로고
    • Defining features of the hair cell mechanoelectrical transducer channel
    • Fettiplace, R. Defining features of the hair cell mechanoelectrical transducer channel. Pflugers Arch. 458, 1115-1123 (2009).
    • (2009) Pflugers Arch. , vol.458 , pp. 1115-1123
    • Fettiplace, R.1
  • 96
    • 0022017195 scopus 로고
    • Mechano-electrical transduction currents in islated vestibular hair cells of the chick
    • Ohmori, H. Mechano-electrical transduction currents in isolated vestibular hair cells of the chick. J. Physiol. (Lond) 359, 189-217 (1985). (Pubitemid 15152934)
    • (1985) Journal of Physiology , vol.VOL. 359 , pp. 189-217
    • Ohmori, H.1
  • 97
    • 0030885522 scopus 로고    scopus 로고
    • The selectivity of the hair cell's mechanoelectrical-transduction channel promotes Ca2+ flux at low Ca2+ concentrations
    • Lumpkin, E. A., Marquis, R. E. & Hudspeth, A. J. The selectivity of the hair cell's mechanoelectrical-transduction channel promotes Ca2+ flux at low Ca2+ concentrations. Proc. Natl Acad. Sci. USA 94, 10997-11002 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 10997-11002
    • Lumpkin, E.A.1    Marquis, R.E.2    Hudspeth, A.J.3
  • 98
    • 0026726645 scopus 로고
    • Mechano-electrical transducer currents in hair cells of the cultured neonatal mouse cochlea
    • Kros, C. J., Rusch, A. & Richardson, G. P. Mechano-electrical transducer currents in hair cells of the cultured neonatal mouse cochlea. Proc. R Soc. Lond. B Biol. Sci. 249, 185-193 (1992).
    • (1992) Proc. R Soc. Lond. B Biol. Sci. , vol.249 , pp. 185-193
    • Kros, C.J.1    Rusch, A.2    Richardson, G.P.3
  • 99
    • 0027498363 scopus 로고
    • Ionic effects on amiloride block of the mechanosensitive channel in Xenopus oocytes
    • Lane, J. W., McBride, D. W. Jr. & Hamill, O. P. Ionic effects on amiloride block of the mechanosensitive channel in Xenopus oocytes. Br. J. Pharmacol. 108, 116-119 (1993). (Pubitemid 23007418)
    • (1993) British Journal of Pharmacology , vol.108 , Issue.1 , pp. 116-119
    • Lane, J.W.1    McBride Jr., D.W.2    Hamill, O.P.3
  • 100
    • 0028085049 scopus 로고
    • Block by amiloride and its derivatives of mechano-electrical transduction in outer hair cells of mouse cochlear cultures
    • Rusch, A., Kros, C. J. & Richardson, G. P. Block by amiloride and its derivatives of mechano-electrical transduction in outer hair cells of mouse cochlear cultures. J. Physiol. (Lond) 474, 75-86 (1994). (Pubitemid 24045634)
    • (1994) Journal of Physiology , vol.474 , Issue.1 , pp. 75-86
    • Rusch, A.1    Kros, C.J.2    Richardson, G.P.3
  • 101
    • 78049273246 scopus 로고    scopus 로고
    • Acid-sensing ion channels (ASICs): Pharmacology and implication in pain
    • Deval, E. et al. Acid-sensing ion channels (ASICs): pharmacology and implication in pain. Pharmacol. Ther. 128, 549-558 (2010).
    • (2010) Pharmacol. Ther. , vol.128 , pp. 549-558
    • Deval, E.1
  • 102
    • 77951978312 scopus 로고    scopus 로고
    • Mechanosensitive gating of CFTR
    • Zhang, W. K. et al. Mechanosensitive gating of CFTR. Nat. Cell Biol. 12, 507-U214 (2010).
    • (2010) Nat. Cell Biol. , vol.12
    • Zhang, W.K.1
  • 103
    • 0033529578 scopus 로고    scopus 로고
    • Molecular identification of a eukaryotic, stretch-activated nonselective cation channel
    • DOI 10.1126/science.285.5429.882
    • Kanzaki, M. et al. Molecular identification of a eukaryotic, stretch-activated nonselective cation channel. Science 285, 882-886 (1999). (Pubitemid 29381987)
    • (1999) Science , vol.285 , Issue.5429 , pp. 882-886
    • Kanzaki, M.1    Nagasawa, M.2    Kojima, I.3    Sato, C.4    Naruse, K.5    Sokabe, M.6    Iida, H.7
  • 104
  • 106
    • 58049127392 scopus 로고    scopus 로고
    • ATP-gated P2X cation-channels
    • Jarvis, M. F. & Khakh, B. S. ATP-gated P2X cation-channels. Neuropharmacology 56, 208-215 (2009).
    • (2009) Neuropharmacology , vol.56 , pp. 208-215
    • Jarvis, M.F.1    Khakh, B.S.2
  • 107
    • 77957332682 scopus 로고    scopus 로고
    • Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels
    • Coste, B. et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330, 55-60 (2010).
    • (2010) Science , vol.330 , pp. 55-60
    • Coste, B.1
  • 108
    • 77952915353 scopus 로고    scopus 로고
    • Eukaryotic mechanosensitive channels
    • Arnadottir, J. & Chalfie, M. Eukaryotic mechanosensitive channels. Annu. Rev. Biophys. 39, 111-137 (2010).
    • (2010) Annu. Rev. Biophys. , vol.39 , pp. 111-137
    • Arnadottir, J.1    Chalfie, M.2
  • 110
    • 33947360830 scopus 로고    scopus 로고
    • 2P channels: Focus on TREK1
    • DOI 10.1038/nrn2117, PII NRN2117
    • Honore, E. The neuronal background K-2P channels: focus on TREK1. Nat. Rev. Neurosci. 8, 251-261 (2007). (Pubitemid 46452327)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.4 , pp. 251-261
    • Honore, E.1
  • 111
    • 38749089813 scopus 로고    scopus 로고
    • Recent advance and possible future in TREK-2: A two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment
    • Huang, D. Y. & Yu, B. W. Recent advance and possible future in TREK-2: A two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment. Med. Hypotheses 70, 618-624 (2008).
    • (2008) Med. Hypotheses , vol.70 , pp. 618-624
    • Huang, D.Y.1    Yu, B.W.2
  • 112
    • 0345118935 scopus 로고    scopus 로고
    • + channels
    • DOI 10.1016/j.tips.2003.10.008
    • Kim, D. Fatty acid-sensitive two-pore domain K+ channels. Trends Pharmacol. Sci. 24, 648-654 (2003). (Pubitemid 37494787)
    • (2003) Trends in Pharmacological Sciences , vol.24 , Issue.12 , pp. 648-654
    • Kim, D.1
  • 113
    • 33646856845 scopus 로고    scopus 로고
    • Molecular basis of human Usher syndrome: Deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease
    • DOI 10.1016/j.exer.2005.11.010, PII S0014483506000686
    • Reiners, J., Nagel-Wolfrum, K., Jurgens, K., Marker, T. & Wolfrum, U. Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease. Exp. Eye Res. 83, 97-119 (2006). (Pubitemid 43783252)
    • (2006) Experimental Eye Research , vol.83 , Issue.1 , pp. 97-119
    • Reiners, J.1    Nagel-Wolfrum, K.2    Jurgens, K.3    Marker, T.4    Wolfrum, U.5
  • 114
    • 65549085188 scopus 로고    scopus 로고
    • Harmonin mutations cause mechanotransduction defects in cochlear hair cells
    • Grillet, N. et al. Harmonin mutations cause mechanotransduction defects in cochlear hair cells. Neuron 62, 375-387 (2009).
    • (2009) Neuron , vol.62 , pp. 375-387
    • Grillet, N.1
  • 116
    • 79954994430 scopus 로고    scopus 로고
    • Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia
    • Caberlotto, E. et al. Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia. Proc. Natl Acad. Sci. USA 108, 5825-5830 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 5825-5830
    • Caberlotto, E.1
  • 118
    • 34250366660 scopus 로고    scopus 로고
    • The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development
    • DOI 10.1002/cm.20199
    • Mogensen, M. M., Rzadzinska, A. & Steel, K. P. The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development. Cell Motil. Cytoskeleton 64, 496-508 (2007). (Pubitemid 46919603)
    • (2007) Cell Motility and the Cytoskeleton , vol.64 , Issue.7 , pp. 496-508
    • Mogensen, M.M.1    Rzadzinska, A.2    Steel, K.P.3
  • 119
    • 67650757671 scopus 로고    scopus 로고
    • Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation
    • Geng, R. et al. Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Hum. Mol. Genet. 18, 2748-2760 (2009).
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 2748-2760
    • Geng, R.1
  • 122
    • 67649861392 scopus 로고    scopus 로고
    • Gamma-actin is required for cytoskeletal maintenance but not development
    • Belyantseva, I. A. et al. Gamma-actin is required for cytoskeletal maintenance but not development. Proc. Natl Acad. Sci. USA 106, 9703-9708 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 9703-9708
    • Belyantseva, I.A.1
  • 123
    • 33750450039 scopus 로고    scopus 로고
    • Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli
    • DOI 10.1007/s00018-006-6148-x
    • Sekerkova, G., Zheng, L., Loomis, P. A., Mugnaini, E. & Bartles, J. R. Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli. Cell Mol. Life Sci. 63, 2329-2341 (2006). (Pubitemid 44653043)
    • (2006) Cellular and Molecular Life Sciences , vol.63 , Issue.19-20 , pp. 2329-2341
    • Sekerkova, G.1    Zheng, L.2    Loomis, P.A.3    Mugnaini, E.4    Bartles, J.R.5
  • 124
    • 77954847853 scopus 로고    scopus 로고
    • The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice
    • Shin, J. B. et al. The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice. J. Neurosci. 30, 9683-9694 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 9683-9694
    • Shin, J.B.1
  • 125
    • 79955786736 scopus 로고    scopus 로고
    • A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
    • Walsh, V. L. et al. A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA. Mamm. Genome 22, 170-177 (2011).
    • (2011) Mamm. Genome , vol.22 , pp. 170-177
    • Walsh, V.L.1
  • 126
    • 55249098639 scopus 로고    scopus 로고
    • A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells
    • Hertzano, R. et al. A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells. PLoS Genet. 4, e1000207 (2008).
    • (2008) PLoS Genet. , vol.4
    • Hertzano, R.1
  • 128
    • 84880297409 scopus 로고    scopus 로고
    • Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human
    • Charizopoulou, N. et al. Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human. Nat. Commun. 2, 201 (2011).
    • (2011) Nat. Commun. , vol.2 , pp. 201
    • Charizopoulou, N.1
  • 129
    • 76049130314 scopus 로고    scopus 로고
    • Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse
    • Odeh, H. et al. Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse. Am. J. Hum. Genet. 86, 148-160 (2010).
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 148-160
    • Odeh, H.1
  • 130
    • 35048861818 scopus 로고    scopus 로고
    • Targeted knockout and lacZ reporter expression of the mouse Tmhs deafness gene and characterization of the hscy-2J mutation
    • DOI 10.1007/s00335-007-9049-x
    • Longo-Guess, C. M., Gagnon, L. H., Fritzsch, B. & Johnson, K. R. Targeted knockout and lacZ reporter expression of the mouse Tmhs deafness gene and characterization of the hscy-2J mutation. Mamm. Genome 18, 646-656 (2007). (Pubitemid 47556515)
    • (2007) Mammalian Genome , vol.18 , Issue.9 , pp. 646-656
    • Longo-Guess, C.M.1    Gagnon, L.H.2    Fritzsch, B.3    Johnson, K.R.4
  • 131
    • 33746217842 scopus 로고    scopus 로고
    • Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea
    • DOI 10.1113/jphysiol.2005.095661
    • Marcotti, W., Erven, A., Johnson, S. L., Steel, K. P. & Kros, C. J. Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea. J. Physiol. 574, 677-698 (2006). (Pubitemid 44089067)
    • (2006) Journal of Physiology , vol.574 , Issue.3 , pp. 677-698
    • Marcotti, W.1    Erven, A.2    Johnson, S.L.3    Steel, K.P.4    Kros, C.J.5
  • 132
    • 33646061333 scopus 로고    scopus 로고
    • TRPA1 contributes to cold, mechanical, and chemical Nociception but is not essential for hair-cell transduction
    • Kwan, K. Y. et al. TRPA1 contributes to cold, mechanical, and chemical Nociception but is not essential for hair-cell transduction. Neuron 50, 277-289 (2006).
    • (2006) Neuron , vol.50 , pp. 277-289
    • Kwan, K.Y.1
  • 133
    • 78650770894 scopus 로고    scopus 로고
    • Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice
    • Jors, S., Grimm, C., Becker, L. & Heller, S. Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice. PLoS ONE 5, e14317 (2010).
    • (2010) PLoS ONE , vol.5
    • Jors, S.1    Grimm, C.2    Becker, L.3    Heller, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.