The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice

Journal of Neuroscience

Volumn 30, Issue 29, 2010, Pages 9683-9694

  Shin, Jung Bum ^a,d   Longo Guess, Chantal M ^c   Gagnon, Leona H ^c   Saylor, Katherine W ^a   Dumont, Rachel A ^a   Spinelli, Kateri J ^a   Pagana, James M ^a   Wilmarth, Phillip A ^a,b   David, Larry L ^a,b   Gillespie, Peter G ^a   Johnson, Kenneth R ^c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c JACKSON LABORATORY   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN 23; FASCIN; FASCIN 2; UNCLASSIFIED DRUG;

AHL8 LOCUS; ANIMAL CELL; ARTICLE; CHICKEN; DBA 2 MOUSE; GENE INTERACTION; GENE LOCUS; GENE MUTATION; HAIR CELL; HAIR GROWTH; HEARING LOSS; MECHANOTRANSDUCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN FUNCTION; STEREOCILIUM; WILD TYPE;

ACTINS; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; CADHERINS; CARRIER PROTEINS; CHICK EMBRYO; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EVOKED POTENTIALS, AUDITORY; HAIR CELLS, AUDITORY, INNER; HEARING LOSS; MICE; MICE, INBRED DBA; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; POLYMORPHISM, GENETIC; SACCULE AND UTRICLE; XENOPUS LAEVIS;

EID: 77954847853     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1541-10.2010     Document Type: Article

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