Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells

Nature

Volumn 449, Issue 7158, 2007, Pages 87-91

  Kazmierczak, Piotr ^a,b   Sakaguchi, Hirofumi ^c   Tokita, Joshua ^c   Wilson Kubalek, Elizabeth M ^a   Milligan, Ronald A ^a   Müller, Ulrich ^a,b   Kachar, Bechara ^c  

^a Departments of Cell Biology   (United States)

^b Institute for Childhood and Neglected Diseases   (United States)

^c NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CADHERIN 23; PROTOCADHERIN 15; UNCLASSIFIED DRUG;

CELL ORGANELLE; ELECTROCHEMISTRY; HAIR; RODENT;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HAIR CELL; HEARING IMPAIRMENT; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; STEREOCILIUM;

RODENTIA;

EID: 34548509448     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06091     Document Type: Article

References (29)

1. Corey, D. Sensory transduction in the ear. J. Cell Sci. 116, 1-3 (2003).
2. Gillespie, P. G. & Walker, R. G. Molecular basis of mechanosensory transduction. Nature 413, 194-202 (2001).
3. Hudspeth, A. J. How hearing happens. Neuron 19, 947-950 (1997).
4. Ahmed, Z. M. et al. The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15. J. Neurosci. 26, 7022-7034 (2006).
5. Lagziel, A. et al. Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development. Dev. Biol. 280, 295-306 (2005).
6. Michel, V. et al. Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells. Dev. Biol. 280, 281-294 (2005).
7. Siemens, J. et al. Cadherin 23 is a component of the tip link in hair-cell stereocilia. Nature 428, 950-955 (2004).
8. Sollner, C. et al. Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells. Nature 428, 955-959 (2004).
9. Kachar, B., Parakkal, M., Kurc, M., Zhao, Y. & Gillespie, P. G. High-resolution structure of hair-cell tip links. Proc. Natl Acad. Sci. USA 97, 13336-13341 (2000).
10. Sotomayor, M., Corey, D. P. & Schulten, K. In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats. Structure 13, 669-682 (2005).
11. Tsuprun, V., Goodyear, R. J. & Richardson, G. P. The structure of tip links and kinocilial links in avian sensory hair bundles. Biophys. J. 87, 4106-4112 (2004).
12. Ahmed, Z. M. et al. Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F. Am. J. Hum. Genet. 69, 25-34 (2001).
13. Bolz, H. et al. Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D. Nature Genet. 27, 108-112 (2001).
14. Bork, J. M. et al. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of the novel cadherin-like gene CDH23. Am. J. Hum. Genet. 68, 26-37 (2001).
15. Di Palma, F. et al. Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D. Nature Genet. 27, 103-107 (2001).
16. Ahmed, Z. M. et al. PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23. Hum. Mol. Genet. 12, 3215-3223 (2003).
17. Assad, J. A., Shepherd, G. M. & Corey, D. P. Tip-link integrity and mechanical transduction in vertebrate hair cells. Neuron 7, 985-994 (1991).
18. Halbleib, J. M. & Nelson, W. J. Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev. 20, 3199-3214 (2006).
19. Boggon, T. J. et al. C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Science 296, 1308-1313 (2002).
20. 2+-NTA gold cluster and single particle analysis. J. Mol. Biol. 312, 371-379 (2001).
21. Anniko, M. & Wroblewski, R. Ionic environment of cochlear hair cells. Hear. Res. 22, 279-293 (1986).
22. Brieher, W. M., Yap, A. S. & Gumbiner, B. M. Lateral dimerization is required for the homophilic binding activity of C-cadherin. J. Cell Biol. 135, 487-496 (1996).
23. Pokutta, S., Herrenknecht, K., Kemler, R. & Engel, J. Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding. Eur. J. Biochem. 223, 1019-1026 (1994).
24. Patel, S. D. et al. Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell 124, 1255-1268 (2006).
25. Phillips, K. R., Tong, S., Goodyear, R., Richardson, G. P. & Cyr, J. L. Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice. J. Neurosci. 26, 10777-10788 (2006).
26. Senften, M. et al. Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. J. Neurosci. 26, 2060-2071 (2006).
27. Schneider, M. E. et al. A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression. J. Neurosci. 26, 10243-10252 (2006).
28. Siemens, J. et al. The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions. Proc. Natl Acad. Sci. USA 99, 14946-14951 (2002).
29. Gillespie, P. G., Dumont, R. A. & Kachar, B. Have we found the tip link, transduction channel, and gating spring of the hair cell? Curr. Opin. Neurobiol. 15, 389-396 (2005)