Engineering a protein-protein interface using a computationally designed library

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 45, 2010, Pages 19296-19301

  Guntas, Gurkan ^a   Purbeck, Carrie ^a   Kuhlman, Brian ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Computational protein design; Protein engineering; Rosetta

Indexed keywords

ALANINE; ARGININE; ASPARAGINE; ASPARTIC ACID; BINDING PROTEIN; CYSTEINE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTIDINE; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; NEDD8 CONJUGATING ENZYME UBC12; PHENYLALANINE; PROLINE; SERINE; THREONINE; TRYPTOPHAN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN CONJUGATING ENZYME UBC12; UBIQUITIN LIGASE E6AP; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; VALINE;

ALGORITHM; AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; BINDING SITE; CALCULATION; COMBINATORIAL LIBRARY; CONFERENCE PAPER; ENZYME ASSAY; ENZYME ENGINEERING; ENZYME STABILITY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN PROTEIN INTERACTION; SIMULATION; SPLIT DIHYDROFOLATE REDUCTASE COMPLEMENTATION ASSAY; SURFACE PROPERTY;

EID: 78650610802     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1006528107     Document Type: Article

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