Diclofenac metabolism in the mouse: Novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry

Xenobiotica

Volumn 42, Issue 2, 2012, Pages 179-194

  Sarda, Sunil ^a   Page, Chris ^a   Pickup, Kathryn ^a   Schulz Utermoehl, Timothy ^a   Wilson, Ian ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Glucosylation; Indolinone; Oxidative decarboxylation; Reactive intermediate; Ribosylation; Taurine conjugation

Indexed keywords

BENZOIC ACID; DICLOFENAC; GLUCOSE; GLUCURONIC ACID; TAURINE;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ARTICLE; DECARBOXYLATION; DRUG DISPOSITION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG URINE LEVEL; GLUTATHIONE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; ION TRAP MASS SPECTROMETRY; MALE; MOUSE; NONHUMAN;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DECARBOXYLATION; DICLOFENAC; GLUCOSE; GLUCURONIC ACID; HYDROXYLATION; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION; TAURINE;

MUS;

EID: 84855447409     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.607865     Document Type: Article

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