Identification of a novel glutathione conjugate of diclofenac by LTQ-orbitrap

Drug Metabolism Letters

Volumn 2, Issue 1, 2008, Pages 35-40

  Teffera, Yohannes ^a   Waldon, Daniel J ^a   Colletti, Adria E ^a   Albrecht, Brian K ^a   Zhao, Zhiyang ^a  

^a AMGEN INC   (United States)

Author keywords

Bioactivation pathway; Diclofenac decarboxylation; DPABA; Glutathione adduct; Reconstructed ion chromatogram

Indexed keywords

2 (2,6 DICHLOROPHENYLAMINO)BENZOIC ACID; BENZOIC ACID DERIVATIVE; DICLOFENAC; GLUTATHIONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DECARBOXYLATION; DRUG ACTIVATION; DRUG CONJUGATION; DRUG DETERMINATION; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, LIQUID; DECARBOXYLATION; DICLOFENAC; GLUTATHIONE; HEPATOCYTES; HUMANS; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 40949162928     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231208783478506     Document Type: Article

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