Integrated HPLC-MS and 1H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides

Xenobiotica

Volumn 40, Issue 1, 2010, Pages 9-23

  Johnson, C H ^a,d   Karlsson, E ^b   Sarda, S ^b   Iddon, L ^c   Iqbal, M ^c,e   Meng, X ^c   Harding, J R ^b   Stachulski, A V ^c   Nicholson, J K ^a   Wilson, I D ^b   Lindon, J C ^a  

^a Sir Alexander Fleming Building ^*  (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d NATIONAL CANCER INSTITUTE   (United States)

^e NATIONAL INSTITUTE FOR BIOTECHNOLOGY AND GENETIC ENGINEERING NIBGE   (Pakistan)

Author keywords

Acyl glucuronide; High performance liquid chromatography mass spectrometry (HPLC MS); Hydrolysis; Ibufenac; Ibuprofen; Nuclear magnetic resonance (NMR) spectroscopy; Plasma; Transacylation

Indexed keywords

1 BETA O ACYL GLUCURONIDE; AGLYCONE; BUFFER; DRUG METABOLITE; GLUCURONIDE; IBUFENAC; IBUPROFEN; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY MASS SPECTROMETRY; HUMAN; HYDROLYSIS; ISOMER; ISOMERIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME;

ACYLATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONIDES; HUMANS; HYDROLYSIS; IBUPROFEN; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHENYLACETATES;

EID: 72949118480     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498250903348720     Document Type: Article

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