Uptake and biological effects of environmentally relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in rainbow trout (oncorhynchus mykiss)

Environmental Science and Technology

Volumn 44, Issue 6, 2010, Pages 2176-2182

  Mehinto, Alvine C ^a   Hill, Elizabeth M ^b   Tyler, Charles R ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORIES; AQUATIC ENVIRONMENTS; BIOCHEMICAL FUNCTIONS; BIOLOGICAL EFFECTS; CELL CYCLE CONTROL; CYCLOOXYGENASES; CYTOCHROME P450; DELETERIOUS EFFECTS; DICLOFENAC; ENVIRONMENTAL CONCENTRATION; EXPRESSION LEVELS; GLUCURONIDES; METHYL ESTERS; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; ONCORHYNCHUS MYKISS; PROSTAGLANDIN SYNTHESIS; RAINBOW TROUT; REACTIVE METABOLITES; SUBCHRONIC EXPOSURE; TISSUE DAMAGE;

BIOCHEMISTRY; BIOLOGICAL RADIATION EFFECTS; BODY FLUIDS; DRUG PRODUCTS; ESTERS; HISTOLOGY; LEAD; LIVER; MEATS; METABOLISM; METABOLITES;

GENE EXPRESSION;

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOCHROME P450 1A1; DICLOFENAC; PROSTAGLANDIN; PROTEIN P53; XENOBIOTIC AGENT;

BIOACCUMULATION; BIOLOGICAL UPTAKE; ENZYME ACTIVITY; GENE; GENE EXPRESSION; METABOLISM; SALMONID; SURFACE WATER; XENOBIOTICS;

ARTICLE; BILE; CELL CYCLE REGULATION; DRUG BILE LEVEL; DRUG METABOLISM; DRUG UPTAKE; FEMALE; GENE EXPRESSION; GILL; HISTOPATHOLOGY; HYPERPLASIA; INTESTINE VILLUS; KIDNEY; KIDNEY TUBULE NECROSIS; NONHUMAN; PROSTAGLANDIN SYNTHESIS; RAINBOW TROUT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL MARKERS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOCHROME P-450 CYP1A1; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; INTESTINES; KIDNEY; LIVER; ONCORHYNCHUS MYKISS; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53; WATER POLLUTANTS, CHEMICAL;

ONCORHYNCHUS MYKISS;

EID: 77949392061     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es903702m     Document Type: Article

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