A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl) aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation

Drug Metabolism and Disposition

Volumn 36, Issue 9, 2008, Pages 1740-1744

  Grillo, Mark P ^a   Ma, Ji ^a   Teffera, Yohannes ^a   Waldon, Daniel J ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2C9; DICLOFENAC; FREE RADICAL; GLUTATHIONE; IMINE; KETOCONAZOLE; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN; QUINIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SULFAPHENAZOLE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; DECARBOXYLATION; DRUG ACTIVATION; DRUG ELIMINATION; DRUG METABOLISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; LIVER TOXICITY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARBOXYLIC ACIDS; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; MICROSOMES, LIVER; OXIDATION-REDUCTION; RATS; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 50049132591     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.021287     Document Type: Article

References (9)

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