Characterization of the xenobiotic response of Caenorhabditis elegans to the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites

Biochemical Journal

Volumn 432, Issue 3, 2010, Pages 505-514

  Laing, Steven T ^a   Ivens, Al ^b   Laing, Roz ^a   Ravikumar, Sai ^c   Butler, Victoria ^c   Woods, Debra J ^d   Gilleard, John S ^c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b Fios Genomics Ltd   (United Kingdom)

^c UNIVERSITY OF CALGARY   (Canada)

^d ZOETIS   (United States)

Author keywords

Anthelmintic resistance; Cytochrome P450; Metabolism; Nematode; UDP glucuronosyl transferase

Indexed keywords

ALBENDAZOLE; ANIMAL USE; ANTHELMINTIC RESISTANCE; CAENORHABDITIS ELEGANS; CYTOCHROME P450; DRUG METABOLISMS; DRUG TARGETS; ELEGANS; GENES ENCODING; HPLC-MS/MS; INTEGRAL PART; MUTANT STRAIN; NEMATODE; STRESS RESPONSE; TRANSCRIPTIONAL RESPONSE; UDP-GLUCURONOSYL TRANSFERASE; XENOBIOTIC-METABOLIZING ENZYMES;

GENES; MAMMALS; METABOLITES;

METABOLISM;

ALBENDAZOLE; BENZIMIDAZOLE; BETA TUBULIN; CYTOCHROME P450; GLUCOSIDE; GLUCURONOSYLTRANSFERASE;

ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DRUG METABOLISM; DRUG TRANSFORMATION; EMBRYO; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTESTINE; MAMMAL; MASS SPECTROMETER; NEMATODE; NONHUMAN; PRIORITY JOURNAL; STRESS; WORM; XENOBIOTIC METABOLISM;

ALBENDAZOLE; ANIMALS; ANTHELMINTICS; CAENORHABDITIS ELEGANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG RESISTANCE; ENZYME INDUCTION; FENOFIBRATE; GENE EXPRESSION PROFILING; GLUCOSIDES; INTESTINES; METABOLIC DETOXICATION, PHASE I; METABOLIC DETOXICATION, PHASE II; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PPAR ALPHA; TANDEM MASS SPECTROMETRY; TUBULIN;

ANIMALIA; CAENORHABDITIS ELEGANS; MAMMALIA; NEMATODA;

EID: 78649847015     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101346     Document Type: Article

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