-
1
-
-
33750438123
-
The Foxa family of transcription factors in development and metabolism
-
Friedman JR, Kaestner KH, (2006) The Foxa family of transcription factors in development and metabolism. Cell Mol Life Sci 63: 2317-2328.
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 2317-2328
-
-
Friedman, J.R.1
Kaestner, K.H.2
-
2
-
-
25144482864
-
Foxa2 integrates the transcriptional response of the hepatocyte to fasting
-
Zhang L, Rubins NE, Ahima RS, Greenbaum LE, Kaestner KH, (2005) Foxa2 integrates the transcriptional response of the hepatocyte to fasting. Cell Metab 2: 141-148.
-
(2005)
Cell Metab
, vol.2
, pp. 141-148
-
-
Zhang, L.1
Rubins, N.E.2
Ahima, R.S.3
Greenbaum, L.E.4
Kaestner, K.H.5
-
3
-
-
11144244418
-
Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
-
Wolfrum C, Asilmaz E, Luca E, Friedman JM, Stoffel M, (2004) Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature 432: 1027-1032.
-
(2004)
Nature
, vol.432
, pp. 1027-1032
-
-
Wolfrum, C.1
Asilmaz, E.2
Luca, E.3
Friedman, J.M.4
Stoffel, M.5
-
4
-
-
32444451567
-
Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion
-
Wolfrum C, Stoffel M, (2006) Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Cell Metab 3: 99-110.
-
(2006)
Cell Metab
, vol.3
, pp. 99-110
-
-
Wolfrum, C.1
Stoffel, M.2
-
5
-
-
49149090637
-
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress
-
Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, et al. (2008) Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nat Med 14: 828-836.
-
(2008)
Nat Med
, vol.14
, pp. 828-836
-
-
Bochkis, I.M.1
Rubins, N.E.2
White, P.3
Furth, E.E.4
Friedman, J.R.5
-
6
-
-
0141705364
-
Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization
-
Wolfrum C, Besser D, Luca E, Stoffel M, (2003) Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. Proc Natl Acad Sci U S A 100: 11624-11629.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 11624-11629
-
-
Wolfrum, C.1
Besser, D.2
Luca, E.3
Stoffel, M.4
-
7
-
-
69949182326
-
Nuclear export-independent inhibition of Foxa2 by insulin
-
Howell JJ, Stoffel M, (2009) Nuclear export-independent inhibition of Foxa2 by insulin. J Biol Chem 284: 24816-24824.
-
(2009)
J Biol Chem
, vol.284
, pp. 24816-24824
-
-
Howell, J.J.1
Stoffel, M.2
-
8
-
-
0035900778
-
Foxa3 (hepatocyte nuclear factor 3gamma) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast
-
Shen W, Scearce LM, Brestelli JE, Sund NJ, Kaestner KH, (2001) Foxa3 (hepatocyte nuclear factor 3gamma) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast. J Biol Chem 276: 42812-42817.
-
(2001)
J Biol Chem
, vol.276
, pp. 42812-42817
-
-
Shen, W.1
Scearce, L.M.2
Brestelli, J.E.3
Sund, N.J.4
Kaestner, K.H.5
-
9
-
-
0033621155
-
Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice
-
Shih DQ, Navas MA, Kuwajima S, Duncan SA, Stoffel M, (1999) Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice. Proc Natl Acad Sci U S A 96: 10152-10157.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 10152-10157
-
-
Shih, D.Q.1
Navas, M.A.2
Kuwajima, S.3
Duncan, S.A.4
Stoffel, M.5
-
10
-
-
33750857693
-
Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation
-
Vatamaniuk MZ, Gupta RK, Lantz KA, Doliba NM, Matschinsky FM, et al. (2006) Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation. Diabetes 55: 2730-2736.
-
(2006)
Diabetes
, vol.55
, pp. 2730-2736
-
-
Vatamaniuk, M.Z.1
Gupta, R.K.2
Lantz, K.A.3
Doliba, N.M.4
Matschinsky, F.M.5
-
11
-
-
0033921664
-
Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte
-
Sund NJ, Ang SL, Sackett SD, Shen W, Daigle N, et al. (2000) Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol 20: 5175-5183.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5175-5183
-
-
Sund, N.J.1
Ang, S.L.2
Sackett, S.D.3
Shen, W.4
Daigle, N.5
-
12
-
-
0031834339
-
Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes
-
Kaestner KH, Hiemisch H, Schutz G, (1998) Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes. Mol Cell Biol 18: 4245-4251.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 4245-4251
-
-
Kaestner, K.H.1
Hiemisch, H.2
Schutz, G.3
-
13
-
-
77949916811
-
Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile
-
Moya M, Jose Gomez-Lechon M, Castell JV, Jover R, (2010) Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. Chem Biol Interact 184: 376-387.
-
(2010)
Chem Biol Interact
, vol.184
, pp. 376-387
-
-
Moya, M.1
Gomez-Lechon, M.J.2
Castell, J.V.3
Jover, R.4
-
14
-
-
0030915005
-
Adenovirus-mediated gene transfer into human hepatocytes: analysis of the biochemical functionality of transduced cells
-
Castell J, Hernandez D, Gomez F, AM, Guillen I, Donato T, et al. (1997) Adenovirus-mediated gene transfer into human hepatocytes: analysis of the biochemical functionality of transduced cells. Gene Ther 4: 455-464.
-
(1997)
Gene Ther
, vol.4
, pp. 455-464
-
-
Castell, J.1
Hernandez, D.2
Gomez, F.A.M.3
Guillen, I.4
Donato, T.5
-
15
-
-
0031577669
-
Peroxisome proliferator activated receptors in Atlantic salmon (Salmo salar): effects on PPAR transcription and acyl-CoA oxidase activity in hepatocytes by peroxisome proliferators and fatty acids
-
Ruyter B, Andersen O, Dehli A, Ostlund Farrants AK, Gjoen T, et al. (1997) Peroxisome proliferator activated receptors in Atlantic salmon (Salmo salar): effects on PPAR transcription and acyl-CoA oxidase activity in hepatocytes by peroxisome proliferators and fatty acids. Biochim Biophys Acta 1348: 331-338.
-
(1997)
Biochim Biophys Acta
, vol.1348
, pp. 331-338
-
-
Ruyter, B.1
Andersen, O.2
Dehli, A.3
Ostlund Farrants, A.K.4
Gjoen, T.5
-
16
-
-
0021809385
-
A sensitive spectrophotometric assay for peroxisomal acyl-CoA oxidase
-
Small GM, Burdett K, Connock MJ, (1985) A sensitive spectrophotometric assay for peroxisomal acyl-CoA oxidase. Biochem J 227: 205-210.
-
(1985)
Biochem J
, vol.227
, pp. 205-210
-
-
Small, G.M.1
Burdett, K.2
Connock, M.J.3
-
17
-
-
77956544811
-
CCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: application to the development of a metabolically competent human hepatic cell model
-
Benet M, Lahoz A, Guzman C, Castell JV, Jover R, (2010) CCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: application to the development of a metabolically competent human hepatic cell model. J Biol Chem 285: 28457-28471.
-
(2010)
J Biol Chem
, vol.285
, pp. 28457-28471
-
-
Benet, M.1
Lahoz, A.2
Guzman, C.3
Castell, J.V.4
Jover, R.5
-
18
-
-
0026083212
-
Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head
-
Lai E, Prezioso VR, Tao WF, Chen WS, Darnell JE Jr, (1991) Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev 5: 416-427.
-
(1991)
Genes Dev
, vol.5
, pp. 416-427
-
-
Lai, E.1
Prezioso, V.R.2
Tao, W.F.3
Chen, W.S.4
Darnell Jr., J.E.5
-
19
-
-
0030798890
-
Fatty acid regulation of very low density lipoprotein production
-
Lewis GF, (1997) Fatty acid regulation of very low density lipoprotein production. Curr Opin Lipidol 8: 146-153.
-
(1997)
Curr Opin Lipidol
, vol.8
, pp. 146-153
-
-
Lewis, G.F.1
-
20
-
-
33846106076
-
A human hepatocellular in vitro model to investigate steatosis
-
Gomez-Lechon MJ, Donato MT, Martinez-Romero A, Jimenez N, Castell JV, et al. (2007) A human hepatocellular in vitro model to investigate steatosis. Chem Biol Interact 165: 106-116.
-
(2007)
Chem Biol Interact
, vol.165
, pp. 106-116
-
-
Gomez-Lechon, M.J.1
Donato, M.T.2
Martinez-Romero, A.3
Jimenez, N.4
Castell, J.V.5
-
21
-
-
33847127557
-
Is membrane transport of FFA mediated by lipid, protein, or both? An unknown protein mediates free fatty acid transport across the adipocyte plasma membrane
-
Kampf JP, Kleinfeld AM, (2007) Is membrane transport of FFA mediated by lipid, protein, or both? An unknown protein mediates free fatty acid transport across the adipocyte plasma membrane. Physiology (Bethesda) 22: 7-14.
-
(2007)
Physiology (Bethesda)
, vol.22
, pp. 7-14
-
-
Kampf, J.P.1
Kleinfeld, A.M.2
-
22
-
-
33745897922
-
Translocation of long chain fatty acids across the plasma membrane-lipid rafts and fatty acid transport proteins
-
Ehehalt R, Fullekrug J, Pohl J, Ring A, Herrmann T, et al. (2006) Translocation of long chain fatty acids across the plasma membrane-lipid rafts and fatty acid transport proteins. Mol Cell Biochem 284: 135-140.
-
(2006)
Mol Cell Biochem
, vol.284
, pp. 135-140
-
-
Ehehalt, R.1
Fullekrug, J.2
Pohl, J.3
Ring, A.4
Herrmann, T.5
-
23
-
-
77956803815
-
FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase
-
Falcon A, Doege H, Fluitt A, Tsang B, Watson N, et al. (2010) FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase. Am J Physiol Endocrinol Metab 299: E384-393.
-
(2010)
Am J Physiol Endocrinol Metab
, vol.299
-
-
Falcon, A.1
Doege, H.2
Fluitt, A.3
Tsang, B.4
Watson, N.5
-
24
-
-
0023836685
-
Acyl-CoA oxidase activity and peroxisomal fatty acid oxidation in rat tissues
-
Reubsaet FA, Veerkamp JH, Bukkens SG, Trijbels JM, Monnens LA, (1988) Acyl-CoA oxidase activity and peroxisomal fatty acid oxidation in rat tissues. Biochim Biophys Acta 958: 434-442.
-
(1988)
Biochim Biophys Acta
, vol.958
, pp. 434-442
-
-
Reubsaet, F.A.1
Veerkamp, J.H.2
Bukkens, S.G.3
Trijbels, J.M.4
Monnens, L.A.5
-
25
-
-
0034289797
-
The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research
-
Del Mar Gonzalez-Barroso M, Ricquier D, Cassard-Doulcier AM, (2000) The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research. Obes Rev 1: 61-72.
-
(2000)
Obes Rev
, vol.1
, pp. 61-72
-
-
Del Mar Gonzalez-Barroso, M.1
Ricquier, D.2
Cassard-Doulcier, A.M.3
-
26
-
-
0025162339
-
HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally
-
Lai E, Prezioso VR, Smith E, Litvin O, Costa RH, et al. (1990) HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. Genes Dev 4: 1427-1436.
-
(1990)
Genes Dev
, vol.4
, pp. 1427-1436
-
-
Lai, E.1
Prezioso, V.R.2
Smith, E.3
Litvin, O.4
Costa, R.H.5
-
27
-
-
0033776792
-
Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis
-
Rausa FM, Tan Y, Zhou H, Yoo KW, Stolz DB, et al. (2000) Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis. Mol Cell Biol 20: 8264-8282.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 8264-8282
-
-
Rausa, F.M.1
Tan, Y.2
Zhou, H.3
Yoo, K.W.4
Stolz, D.B.5
-
28
-
-
0037566080
-
Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage
-
Hughes DE, Stolz DB, Yu S, Tan Y, Reddy JK, et al. (2003) Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. Hepatology 37: 1414-1424.
-
(2003)
Hepatology
, vol.37
, pp. 1414-1424
-
-
Hughes, D.E.1
Stolz, D.B.2
Yu, S.3
Tan, Y.4
Reddy, J.K.5
-
29
-
-
0036138553
-
Adenovirus-mediated increase in HNF-3beta or HNF-3alpha shows differences in levels of liver glycogen and gene expression
-
Tan Y, Hughes D, Wang X, Costa RH, (2002) Adenovirus-mediated increase in HNF-3beta or HNF-3alpha shows differences in levels of liver glycogen and gene expression. Hepatology 35: 30-39.
-
(2002)
Hepatology
, vol.35
, pp. 30-39
-
-
Tan, Y.1
Hughes, D.2
Wang, X.3
Costa, R.H.4
-
30
-
-
34547946930
-
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance
-
Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, et al. (2007) Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J Biol Chem 282: 22678-22688.
-
(2007)
J Biol Chem
, vol.282
, pp. 22678-22688
-
-
Choi, C.S.1
Savage, D.B.2
Kulkarni, A.3
Yu, X.X.4
Liu, Z.X.5
-
31
-
-
23044450772
-
Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice
-
Yu XX, Murray SF, Pandey SK, Booten SL, Bao D, et al. (2005) Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice. Hepatology 42: 362-371.
-
(2005)
Hepatology
, vol.42
, pp. 362-371
-
-
Yu, X.X.1
Murray, S.F.2
Pandey, S.K.3
Booten, S.L.4
Bao, D.5
-
32
-
-
19944432614
-
Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity
-
Ishigaki Y, Katagiri H, Yamada T, Ogihara T, Imai J, et al. (2005) Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. Diabetes 54: 322-332.
-
(2005)
Diabetes
, vol.54
, pp. 322-332
-
-
Ishigaki, Y.1
Katagiri, H.2
Yamada, T.3
Ogihara, T.4
Imai, J.5
-
33
-
-
0032584567
-
Regulation of a transcription factor network required for differentiation and metabolism
-
Duncan SA, Navas MA, Dufort D, Rossant J, Stoffel M, (1998) Regulation of a transcription factor network required for differentiation and metabolism. Science 281: 692-695.
-
(1998)
Science
, vol.281
, pp. 692-695
-
-
Duncan, S.A.1
Navas, M.A.2
Dufort, D.3
Rossant, J.4
Stoffel, M.5
-
34
-
-
0035108279
-
Validities of mRNA quantification using recombinant RNA and recombinant DNA external calibration curves in real-time RT-PCR
-
Pfaffl M, Hageleit M, (2001) Validities of mRNA quantification using recombinant RNA and recombinant DNA external calibration curves in real-time RT-PCR. Biotechnology Letters 23: 275-282.
-
(2001)
Biotechnology Letters
, vol.23
, pp. 275-282
-
-
Pfaffl, M.1
Hageleit, M.2
-
35
-
-
75449094816
-
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
-
Fabbrini E, Sullivan S, Klein S, (2010) Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 51: 679-689.
-
(2010)
Hepatology
, vol.51
, pp. 679-689
-
-
Fabbrini, E.1
Sullivan, S.2
Klein, S.3
-
36
-
-
20444374087
-
Does chasing selected 'Fox' to the nucleus prevent diabetes?
-
Wang H, Wollheim CB, (2005) Does chasing selected 'Fox' to the nucleus prevent diabetes? Trends Mol Med 11: 262-265.
-
(2005)
Trends Mol Med
, vol.11
, pp. 262-265
-
-
Wang, H.1
Wollheim, C.B.2
-
37
-
-
40549135297
-
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
-
Postic C, Girard J, (2008) Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 118: 829-838.
-
(2008)
J Clin Invest
, vol.118
, pp. 829-838
-
-
Postic, C.1
Girard, J.2
-
38
-
-
33847404482
-
Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease
-
Samuel VT, Liu ZX, Wang A, Beddow SA, Geisler JG, et al. (2007) Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. J Clin Invest 117: 739-745.
-
(2007)
J Clin Invest
, vol.117
, pp. 739-745
-
-
Samuel, V.T.1
Liu, Z.X.2
Wang, A.3
Beddow, S.A.4
Geisler, J.G.5
-
39
-
-
0035370569
-
Protein kinase C-mediated down-regulation of MDR3 mRNA expression in Chang liver cells
-
Wakusawa S, Ikeda R, Shiono Y, Hayashi H, (2001) Protein kinase C-mediated down-regulation of MDR3 mRNA expression in Chang liver cells. Biochem Pharmacol 61: 1339-1345.
-
(2001)
Biochem Pharmacol
, vol.61
, pp. 1339-1345
-
-
Wakusawa, S.1
Ikeda, R.2
Shiono, Y.3
Hayashi, H.4
-
40
-
-
0033032848
-
PKC-dependent phosphorylation of the p97 repressor regulates the transcription of aldolase A L-type promoter
-
Costanzo P, Lupo A, Medugno L, D'Agostino P, Zevino C, et al. (1999) PKC-dependent phosphorylation of the p97 repressor regulates the transcription of aldolase A L-type promoter. FEBS Lett 454: 61-66.
-
(1999)
FEBS Lett
, vol.454
, pp. 61-66
-
-
Costanzo, P.1
Lupo, A.2
Medugno, L.3
D'Agostino, P.4
Zevino, C.5
|