Elevated hepatocyte levels of the Forkhead box A2 (HNF-3β) transcription factor cause postnatal steatosis and mitochondrial damage

Hepatology

Volumn 37, Issue 6, 2003, Pages 1414-1424

  Hughes, Douglas E ^a   Stolz, Donna Beer ^b   Yu, Songtao ^c   Tan, Yongjun ^a   Reddy, Janardan K ^c   Watkins, Simon C ^b   Diehl, Anna Mae ^d   Costa, Robert H ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCAGON; GLUCOSE; GLYCOGEN; HEPATOCYTE NUCLEAR FACTOR 3; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 3GAMMA; INSULIN; KETONE BODY; PREALBUMIN; REACTIVE OXYGEN METABOLITE; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; GENE EXPRESSION REGULATION; GLUCAGON BLOOD LEVEL; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; INSULIN BLOOD LEVEL; LIVER CELL; LIVER INJURY; MITOCHONDRIAL MEMBRANE; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STEATOSIS; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0037566080     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2003.50253     Document Type: Article

References (41)

1. Kaestner KH, Knochel W, Martinez DE. Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev 2000;14:142-146.
2. Clark KL, Halay ED, Lai E, Burley SK. Co-crystal structure of the HNF-3/fork head DNA recognition motif resembles histone H5. Nature 1993;364:412-420.
3. Wang X, Kiyokawa H, Dennewitz MB, Costa RH. The forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc Natl Acad Sci U S A 2002;99:16881-16886.
4. Carlsson P, Mahlapuu M. Forkhead transcription factors: key players in development and metabolism. Dev Biol 2002;250:1-23.
5. Costa RH, Kalinichenko VV, Lim L. Transcription factors in mouse lung development and function. Am J Physiol Lung Cell Mol Physiol 2001;280:L823-L838.
6. Duncan SA. Mechanisms controlling early development of the liver. Mech Dev 2003;120:19-33.
7. Zaret KS. Regulatory phases of early liver development: paradigms of organogenesis. Nat Rev Genet 2002;3:499-512.
8. Kaestner KH. The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism. Trends Endocrinol Metab 2000;11:281-285.
9. Lai E, Prezioso VR, Tao WF, Chen WS, Darnell JE, Jr. Hepatocyte nuclear factor 3α belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev 1991;5:416-427.
10. Overdier DG, Porcella A, Costa RH. The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix. Mol Cell Biol 1994;14:2755-2766.
11. Samadani U, Costa RH. The transcriptional activator hepatocyte nuclear factor six regulates liver gene expression. Mol Cell Biol 1996;16:6273-6284.
12. Costa RH, Holterman A-X, Rausa FM, Adami G: Gene regulation and in vivo function of liver transcription factors. In: Arias IM, Boyer JL, Chisari FV, Fausto N, Schachter D, Shafritz D, eds. The Liver: Biology and Pathobiology. 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2001;59-75.
13. Darlington GJ. Molecular mechanisms of liver development and differentiation. Curr Opin Cell Biol 1999;11:678-682.
14. Ang SL, Wierda A, Wong D, Stevens KA, Cascio S, Rossant J, Zaret KS. The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 1993;119:1301-1315.
15. Monaghan AP, Kaestner KH, Grau E, Schutz G. Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development 1993;119:567-578.
16. Ruiz i Altaba A, Prezioso VR, Darnell JE, Jessell TM. Sequential expression of HNF-3β and HNF-3α by embryonic organizing centers: the dorsal lip/node, notochord and floor plate. Mech Dev 1993;44:91-108.
17. Sasaki H, Hogan BL. Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 1993;118:47-59.
18. Ang SL, Rossant J. HNF-3β is essential for node and notochord formation in mouse development. Cell 1994;78:561-574.
19. Weinstein DC, Ruiz i Altaba A, Chen WS, Hoodless P, Prezioso VR, Jessell TM, Darnell JE, Jr. The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo. Cell 1994;78:575-588.
20. Sund NJ, Ang SL, Sackett SD, Shen W, Daigle N, Magnuson MA, Kaestner KH. Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol 2000;20:5175-5183.
21. Rausa FM, Tan Y, Zhou H, Yoo K, Stolz DB, Watkins S, Franks RR, et al. Elevated levels of HNF-3β in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis. Mol Cell Biol 2000;20:8264-8282.
22. Tan Y, Hughes DE, Wang X, Costa RH. Adenovirus-mediated hepatic increase in HNF-3β or HNF-3α shows differences in levels of liver glycogen and gene expression. HEPATOLOGY 2002;35:30-39.
23. Tan Y, Adami G, Costa RH. Maintaining HNF-6 expression prevents AdHNF3β mediated decrease in hepatic levels of Glut2 and glycogen. HEPATOLOGY 2002;35:790-798.
24. Green R. Grant/Riverside Methodist Hospitals, Grant Histology Procedure Manual. 1994.
25. Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 1999;274:305-315.
26. Shen W, Scearce LM, Brestelli JE, Sund NJ, Kaestner KH. Foxa3 (hepatocyte nuclear factor 3gamma) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast. J Biol Chem 2001;276:42812 42817.
27. Sambrook J, Russell DW. Molecular cloning: a laboratory manual. 3rd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2001.
28. Hashimoto T, Fujita T, Usuda N, Cook W, Qi C, Peters JM, Gonzalez FJ, et al. Peroxisomal and mitochondrial fatry acid beta-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotype. J Biol Chem 1999;274:19228-19236.
29. Hashimoto T, Cook W, Qi C, AV Y, Reddy J, Rao M. Defect in peroxisome proliferator activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J Biol Chem 2000;275:28918-28928.
30. Jaeschke H. Reactive oxygen and mechanisms of inflammatory liver injury. J Gastroenterol Hepatol 2000;15:718-724.
31. Kersten S. Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO Rep 2001;2:282-286.
32. Pepponi R, Graziani G, Falcinelli S, Vernole P, Levati L, Lacal PM, Pagani E, et al. hMSH3 overexpression and cellular response to cytotoxic anticancer agents. Carcinogenesis 2001;22:1131-1137.
33. van Loo G, Schotte P, van Gurp M, Demol H, Hoorelbeke B, Gevaert K, Rodriguez I, et al. Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ 2001;8:1136-1142.
34. Polimeno L, Capuano F, Marangi L, Margiotta M, Lisowsky T, Ierardi E, Francavilla R, et al. The augmenter of liver regeneration induces mitochondrial gene expression in rat liver and enhances oxidative phosphorylation capacity of liver mitochondria. Dig Liver Dis 2000;32:510-517.
35. Chen J, Ishac E, Dent P, Kunos G, Gao B. Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver. Biochem J 1998;334:669-676.
36. Zachman RD, Grummer MA. Prenatal ethanol consumption increases retinol and cellular retinol-binding protein expression in the rat fetal snout. Biol Neonate 2001;80:152-157.
37. Bollen M, Keppens S, Stalmans W. Specific features of glycogen metabolism in the liver. Biochem J 1998;336:19-31.
38. Eaton S, Bartlett K, Pourfarzam M. Mammalian mitochondrial beta-oxidation. Biochem J 1996;320:345-357.
39. Masters C. Gluconeogenesis and the peroxisome. Mol Cell Biochem 1997;166:159-168.
40. Yang S, Zhu H, Li Y, Lin H, Gabrielson K, Trush MA, Diehl AM. Mitochondrial adaptations to obesity-related oxidant stress. Arch Biochem Biophys 2000;378:259-268.
41. Rausa F, Tan Y, Costa RH. Association between HNF-6 and FoxA2 DNA Binding Domains Stimulates FoxA2 Transcriptional Activity but Inhibits HNF-6 DNA Binding. Mol Cell Biol 2003;23:437-449.