Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p

EMBO Journal

Volumn 20, Issue 12, 2001, Pages 3124-3131

  Walter, J ^a   Urban, J ^a   Volkwein, C ^a   Sommer, T ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Proteasome; Sec61p tail anchored protein; Ubc6p; Yeast

Indexed keywords

CYSTEINE; MEMBRANE PROTEIN; UBIQUITIN CONJUGATING ENZYME;

ARTICLE; CATALYSIS; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN TRANSPORT;

CARRIER PROTEINS; CYSTEINE ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; INTRACELLULAR MEMBRANES; LIGASES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; SACCHAROMYCES CEREVISIAE PROTEINS; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

EID: 0035875921     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.12.3124     Document Type: Article

References (37)

1. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation
2. Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway
3. Role of Cue1p in ubiquitination and degradation at the ER surface
4. Ubiquitin and the control of protein fate in the secretory and endocytic pathways
5. Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor
6. Dissociation from BiP and retrotranslocation of unassembled immunoglobulin light chains are tightly coupled to proteasome activity
7. Structure and functions of the 20S and 26S proteasomes
8. Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: A link between the apoptosome and the proteasome pathway
9. Inhibition of proteolysis and cell cycle progression in a multiubiquitination deficient yeast mutant
10. A regulatory link between ER-associated protein degradation and the unfolded-protein response
11. 2/metaphase
12. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein
13. Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: Mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival
14. The active sites of the eukaryotic 20S proteasome and their involvement in subunit precursor processing
15. The ubiquitin system
16. ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway
17. The translocon: A dynamic gateway at the ER membrane
18. Resistance to cadmium mediated by ubiquitin-dependent proteolysis
19. Der1p, a novel protein specifically required for endoplasmic reticulum degradation in yeast
20. A class of membrane proteins with a C-terminal anchor
21. Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane
22. Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein
23. Tripartite management of unfolded proteins in the endoplasmic reticulum
24. Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation
25. Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation
26. Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes
27. In vivo function of the proteasome in the ubiquitin pathway
28. Ubc1 encodes a novel member of an essential subfamily of yeast ubiquitin-conjugation enzymes involved in protein degradation
29. A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum
30. Endoplasmic reticulum degradation: Reverse protein flow of no return
31. Recognition of the polyubiquitin proteolytic signal
32. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
33. HRD gene dependence of endoplasmic reticulum associated degradation
34. The transmembrane domain of a carboxyl-terminal anchored protein determines localization to the endoplasmic reticulum
35. The engagement of Sec61p in the ER dislocation process