The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin and increases its solubility

Molecular and Cellular Biochemistry

Volumn 346, Issue 1-2, 2011, Pages 137-145

  Wang, Haiping ^a   Li, Qi ^a   Shen, Yujun ^a   Sun, Aimin ^a   Zhu, Xiaoguang ^b   Fang, Shengyun ^c   Shen, Yuxian ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b BENGBU MEDICAL COLLEGE   (China)

^c UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

Alpha 1 antitrypsin Z variant; ER associated degradation; Hrd1; Ubiquitin proteasome pathway

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALPHA 1 ANTITRYPSIN Z; CYCLOHEXIMIDE; PROTEASOME; UBIQUITIN; UBIQUITIN LIGASE HRD1; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL STRUCTURE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; GENETIC VARIABILITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; INTRACELLULAR MEMBRANE; PLASMID; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SOLUBILITY;

ALPHA 1-ANTITRYPSIN; BASE SEQUENCE; DNA PRIMERS; HUMANS; HYDROLYSIS; RNA INTERFERENCE; SOLUBILITY; UBIQUITIN-PROTEIN LIGASES;

EID: 78751621901     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0600-9     Document Type: Article

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