Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: Cross-talk between E3s in the endoplasmic reticulum

Biochemical and Biophysical Research Communications

Volumn 390, Issue 3, 2009, Pages 758-762

  Shmueli, Ayelet ^a   Tsai, Yien Che ^a   Yang, Mei ^a   Braun, Mary A ^a   Weissman, Allan M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Atherosclerosis; Autocrine motility factor receptor; KAI1; Pael R; Parkinson's disease; RNF45

Indexed keywords

BETA ACTIN; GREEN FLUORESCENT PROTEIN; MEMBRANE PROTEIN; PROTEASOME; PROTEIN GP78; PROTEIN HRD1; PROTEIN INSIG 1; RING FINGER PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; MAMMAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; ENDOPLASMIC RETICULUM; HUMANS; MICE; PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTORS, CYTOKINE; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

MAMMALIA;

EID: 70449729362     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.10.045     Document Type: Article

References (23)

1. Nakatsukasa K., and Brodsky J.L. The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum. Traffic 9 (2008) 861-870
2. Ron D., and Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8 (2007) 519-529
3. Kostova Z., Tsai Y.C., and Weissman A.M. Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation. Semin. Cell Dev. Biol. 18 (2007) 770-779
4. Omura T., Kaneko M., Okuma Y., Orba Y., Nagashima K., Takahashi R., Fujitani N., Matsumura S., Hata A., Kubota K., Murahashi K., Uehara T., and Nomura Y. A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. J. Neurochem. 99 (2006) 1456-1469
5. Amano T., Yamasaki S., Yagishita N., Tsuchimochi K., Shin H., Kawahara K., Aratani S., Fujita H., Zhang L., Ikeda R., Fujii R., Miura N., Komiya S., Nishioka K., Maruyama I., Fukamizu A., and Nakajima T. Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev. 17 (2003) 2436-2449
6. Chen B., Mariano J., Tsai Y.C., Chan A.H., Cohen M., and Weissman A.M. The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. Proc. Natl. Acad. Sci. USA 103 (2006) 341-346
7. Song B.L., Sever N., and DeBose-Boyd R.A. Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. Mol. Cell 19 (2005) 829-840
8. Lee J.N., Song B., DeBose-Boyd R.A., and Ye J. Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78. J. Biol. Chem. 281 (2006) 39308-39315
9. Liang J.S., Kim T., Fang S., Yamaguchi J., Weissman A.M., Fisher E.A., and Ginsberg H.N. Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. J. Biol. Chem. 278 (2003) 23984-23988
10. Pabarcus M.K., Hoe N., Sadeghi S., Patterson C., Wiertz E., and Correia M.A. CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. Arch. Biochem. Biophys. 483 (2009) 66-74
11. Z. Ying, H. Wang, H. Fan, X. Zhu, J. Zhou, E. Fei, G. Wang, Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation, Hum. Mol. Genet. (2009) [Epub ahead of print].
12. Shen Y., Ballar P., and Fang S. Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin. Biochem. Biophys. Res. Commun. 349 (2006) 1285-1293
13. Morito D., Hirao K., Oda Y., Hosokawa N., Tokunaga F., Cyr D.M., Tanaka K., Iwai K., and Nagata K. Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508. Mol. Biol. Cell 19 (2008) 1328-1336
14. Tsai Y.C., Mendoza A., Mariano J.M., Zhou M., Kostova Z., Chen B., Veenstra T., Hewitt S.M., Helman L.J., Khanna C., and Weissman A.M. The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation. Nat. Med. 13 (2007) 1504-1509
15. Das R., Mariano J., Tsai Y.C., Kalathur R.C., Kostova Z., Li J., Tarasov S.G., McFeeters R.L., Altieri A.S., Ji X., Byrd R.A., and Weissman A.M. Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78. Mol. Cell 34 (2009) 674-685
16. Ye Y., Shibata Y., Kikkert M., van Voorden S., Wiertz E., and Rapoport T.A. Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc. Natl. Acad. Sci. USA 102 (2005) 14132-14138
17. Yagishita N., Ohneda K., Amano T., Yamasaki S., Sugiura A., Tsuchimochi K., Shin H., Kawahara K., Ohneda O., Ohta T., Tanaka S., Yamamoto M., Maruyama I., Nishioka K., Fukamizu A., and Nakajima T. Essential role of synoviolin in embryogenesis. J. Biol. Chem. 280 (2005) 7909-7916
18. Kikkert M., Doolman R., Dai M., Avner R., Hassink G., van Voorden S., Thanedar S., Roitelman J., Chau V., and Wiertz E. Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. J. Biol. Chem. 279 (2004) 3525-3534
19. Imai Y., Soda M., Inoue H., Hattori N., Mizuno Y., and Takahashi R. An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 105 (2001) 891-902
20. Dobrosotskaya I.Y., Goldstein J.L., Brown M.S., and Rawson R.B. Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs. J. Biol. Chem. 278 (2003) 35837-35843
21. Treier M., Staszewski L.M., and Bohmann D. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78 (1994) 787-798
22. Magnifico A., Ettenberg S., Yang C., Mariano J., Tiwari S., Fang S., Lipkowitz S., and Weissman A.M. WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation. J. Biol. Chem. 278 (2003) 43169-43177
23. Benmaamar R., and Pagano M. Involvement of the SCF complex in the control of Cdh1 degradation in S-phase. Cell Cycle 4 (2005) 1230-1232