Synthesis, anti-inflammatory activity and ulcerogenic liability of novel nitric oxide donating/chalcone hybrids

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 195-206

  Abuo Rahma, Gamal El Din A A ^a   Abdel Aziz, Mohamed ^a   Mourad, Mai A E ^a   Farag, Hassan H ^b  

^a Minia University   (Egypt)

^b Assiut University   (Egypt)

Author keywords

Anti inflammatory; Chalcones; Gastric ulceration; Histopathology; Nitric oxide donors

Indexed keywords

1 (4 AMINOPHENYL) 3 ARYLPROP 2 EN 1 ONE; 2 (4 ACETYLPHENOXY) N [4 (3 BENZO[1,3]DIOXOL 5 YLACRYLOYL)PHENYL]ACETAMIDE; 2 (4 ACETYLPHENOXY) N [4 (3 FURAN 2 YLACRYLOYL)PHENYL]ACETAMIDE; 2 (4 ACETYLPHENOXY) N [4 [3 (4 CHLOROPHENYL)ACRYLOYL]PHENYL]ACETAMIDE; 2 (4 ACETYLPHENOXY) N [4 [3 (4 METHOXYPHENYL)ACRYLOYL]PHENYL]ACETAMIDE; 2 [4 ( HYDROXYIMINOETHYL)PHENOXY] N [4 [3 (4 METHOXYPHENYL)ACRYLOYL]PHENYL]ACETAMIDE; 2 BROMO N [4 (3 ARYLACRYLOYL)PHENYL]ACETAMIDE DERIVATIVE; 2 BROMO N [4 (3 FURAN 2 YLACRYLOYL)PHENYL]ACETAMIDE; 2 BROMO N [4 (3 FURAN 2 YLACRYLOYL)PHENYL]PROPIONAMIDE; 2 BROMO N [4 [3 (4 CHLOROPHENYL)ACRYLOYL]PHENYL]ACETAMIDE; 2 BROMO N [4 [3 (4 CHLOROPHENYL)ACRYLOYL]PHENYL]PROPIONAMIDE; 2 BROMO N [4 [3 (4 METHOXYPHENYL)ACRYLOYL]PHENYL]ACETAMIDE; 2 BROMO N [4 [3 (4 METHOXYPHENYL)ACRYLOYL]PHENYL]PROPIONAMIDE; 3 PHENYL 4 FUROXANMETHANOL; ANTIINFLAMMATORY AGENT; CHALCONE DERIVATIVE; INDOMETACIN; N [4 (3 BENZO[1,3]DIOXOL 5 YLACRYLOYL)PHENYL] 2 [4 (1 HYDROXYIMINOETHYL)PHENOXY]ACETAMIDE; N [4 (3 BENZO[1,3]DIOXOL 5 YLACRYLOYL)PHENYL] 2 BROMOACETAMIDE; N [4 (3 BENZO[1,3]DIOXOL 5 YLACRYLOYL)PHENYL] 2 BROMOPROPIONAMIDE; N [4 (3 BENZO[1,3]DIOXOL 5 YLACRYLOYL)PHENYL] 2 NITROOXYACETAMIDE; N [4 (3 FURAN 2 YLACRYLOYL)PHENYL] 2 NITROOXYACETAMIDE; N [4 (3 FURAN 2 YLACRYLOYL)PHENYL] 2 NITROOXYPROPIONAMIDE; N [4 [3 (4 CHLOROPHENYL)ACRYLOYL]PHENYL] 2 [4 (1 HYDROXYIMINOETHYL)PHENOXY]ACETAMIDE; N [4 [3 (4 CHLOROPHENYL)ACRYLOYL]PHENYL] 2 NITROOXYACETAMIDE; N [4 [3 (4 CHLOROPHENYL)ACRYLOYL]PHENYL] 2 NITROOXYPROPIONAMIDE; N [4 [3 (4 METHOXYPHENYL)ACRYLOYL]PHENYL] 2 NITROOXYACETAMIDE; N [4 [3 (4 METHOXYPHENYL)ACRYLOYL]PHENYL] 2 NITROOXYPROPIONAMIDE; NITRIC OXIDE DONOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HISTOPATHOLOGY; MALE; MUCOSA; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STOMACH ULCER;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CHALCONE; EDEMA; GASTROINTESTINAL TRACT; INDOMETHACIN; NITRIC OXIDE; NITRIC OXIDE DONORS; RATS;

RATTUS;

EID: 84855186971     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.012     Document Type: Article

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