Synthesis and antimalarial activity of sulfonamide chalcone derivatives

Farmaco

Volumn 60, Issue 4, 2005, Pages 307-311

  Domínguez, José N ^a,b   León, Caritza ^a   Rodrigues, Juan ^b   De Domínguez, Neira Gamboa ^b   Gut, Jiri ^c   Rosenthal, Philip J ^c  

^a UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antimalarial; Chalcone; Sulfonamide; Synthesis; hematin

Indexed keywords

1 [4' N (2'',5'' DICHLOROPHENYL)SULFONYLAMIDE PHENYL] 3 (2,4 DICHLOROPHENYL) 2 PROPEN 1 ONE; 1 [4' N (2'',5'' DICHLOROPHENYL)SULFONYLAMIDE PHENYL] 3 (2,4 DIFLUOROPHENYL) 2 PROPEN 1 ONE; 1 [4' N (2'',5'' DICHLOROPHENYL)SULFONYLAMIDE PHENYL] 3 (2,4 DIMETHOXYPHENYL) 2 PROPEN 1 ONE; 1 [4' N (2'',5'' DICHLOROPHENYL)SULFONYLAMIDE PHENYL] 3 (3 PYRIDINYL) 2 PROPEN 1 ONE; 1 [4' N (2'',5'' DICHLOROPHENYL)SULFONYLAMIDE PHENYL] 3 (3,4 METHYLENDIOXYPHENYL) 2 PROPEN 1 ONE; 1 [4' N (2'',5'' DICHLOROPHENYL)SULFONYLAMIDE PHENYL] 3 (3,4,5 TRIMETHOXYPHENYL) 2 PROPEN 1 ONE; 1 [4' N (2'',5'' DICHLOROPHENYL)SULFONYLAMIDE PHENYL] 3 (4 CHLOROPHENYL) 2 PROPEN 1 ONE; 1 [4' N (2'',5'' DICHLOROPHENYL)SULFONYLAMIDE PHENYL] 3 (4 FLUOROPHENYL) 2 PROPEN 1 ONE; 1 [4' N (2'',5'' DICHLOROPHENYL)SULFONYLAMIDE PHENYL] 3 (4 METHOXYPHENYL) 2 PROPEN 1 ONE; 1 [4' N (2'',5'' DICHLOROPHENYL)SULFONYLAMIDE PHENYL] 3 (4 METHYLPHENYL) 2 PROPEN 1 ONE; 1 [4' N (2'',5'' DICHLOROPHENYL)SULFONYLAMIDE PHENYL] 3 PHENYL 2 PROPEN 1 ONE; ANTIMALARIAL AGENT; CHALCONE DERIVATIVE; CHLOROQUINE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG TARGETING; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; PLASMODIUM FALCIPARUM; SUBSTITUTION REACTION;

EID: 17444391238     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2005.01.005     Document Type: Article

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