Design, synthesis, and evaluation of anti-inflammatory, analgesic, ulcerogenicity, and nitric oxide releasing studies of novel indomethacin analogs as non-ulcerogenic derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 25, Issue 4, 2010, Pages 520-530

  Bhandari, Shashikant V ^a   Parikh, Jignesh K ^a   Bothara, Kailash G ^a   Chitre, Trupti S ^a   Lokwani, Deepak K ^a   Devale, Titiksh L ^a   Modhave, Nileema S ^a   Pawar, Vidya S ^a   Panda, Santosh ^a  

^a AISSMS COLLEGE OF PHARMACY   (India)

Author keywords

1,3,4 oxadiazole; Hybrid drugs; Indomethacin; Nitric oxide donor; Ulcerogenicity

Indexed keywords

2 (5 (2 PHENYL 1 H INDOL 5 YL) 1,3,4 OXADIAZOLE 2YLTHIO) 1 (3 HYDROXYPHENYL)ETHANONE; 2 (5 (2 PHENYL 1 H INDOL 5 YL) 1,3,4 OXADIAZOLE 2YLTHIO) 1 (3 NITROPHENYL)ETHANONE; 2 (5 (2 PHENYL 1 H INDOL 5 YL) 1,3,4 OXADIAZOLE 2YLTHIO) 1 (3,4 DIMETHOXYPHENYL)ETHANONE; 2 (5 (2 PHENYL 1 H INDOL 5 YL) 1,3,4 OXADIAZOLE 2YLTHIO) 1 (4 HYDROXYPHENYL)ETHANONE; 2 (5 (2 PHENYL 1 H INDOL 5 YL) 1,3,4 OXADIAZOLE 2YLTHIO) 1 (4 NITROPHENYL)ETHANONE; 2 (5 (2 PHENYL 1 H INDOL 5 YL) 1,3,4 OXADIAZOLE 2YLTHIO) 1 (PHENYL)ETHANONE; 2 CHLORO 1 (5 (5 (2 (3 HYDROXYPHENYL) 2 OXO 2 PHENYLETHYLTHIO) 1,3,4 OXADIAZOLE 2 YL) 2 PHENYL 1H INDOL 1 YL)ETHANONE; 2 CHLORO 1 (5 (5 (2 (3 NITROPHENYL) 2 OXO 2 PHENYLETHYLTHIO) 1,3,4 OXADIAZOLE 2 YL) 2 PHENYL 1H INDOL 1 YL)ETHANONE; 2 CHLORO 1 (5 (5 (2 (3,4 DIMETHOXYPHENYL) 2 OXO 2 PHENYLETHYLTHIO) 1,3,4 OXADIAZOLE 2 YL) 2 PHENYL 1H INDOL 1 YL)ETHANONE; 2 CHLORO 1 (5 (5 (2 (4 HYDROXYPHENYL) 2 OXO 2 PHENYLETHYLTHIO) 1,3,4 OXADIAZOLE 2 YL) 2 PHENYL 1H INDOL 1 YL)ETHANONE; 2 CHLORO 1 (5 (5 (2 (4 NITROPHENYL) 2 OXO 2 PHENYLETHYLTHIO) 1,3,4 OXADIAZOLE 2 YL) 2 PHENYL 1H INDOL 1 YL)ETHANONE; 2 CHLORO 1 (5 (5 (2 OXO 2 PHENYLETHYLTHIO) 1,3,4 OXADIAZOLE 2 YL) 2 PHENYL 1 H INDOL 1 YL)ETHANONE; 2 OXO 2 (5 (5 (2 OXO 2 PHENYLETHYLTHIO) 1,3,4 OXADIAZOLE 2 YL) 2 PHENYL 1H INDOL 1 YL)ETHYL NITRATE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ANTIULCER AGENT; DICLOFENAC; INDOMETACIN DERIVATIVE; NITRIC OXIDE DONOR; UNCLASSIFIED DRUG; INDOMETACIN; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HISTOPATHOLOGY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICALLY INDUCED; GASTROINTESTINAL DISEASE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; ULCER;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG DESIGN; GASTROINTESTINAL DISEASES; INDOMETHACIN; NITRIC OXIDE; STRUCTURE-ACTIVITY RELATIONSHIP; ULCER;

EID: 77954398500     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756360903357585     Document Type: Article

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