A new class of ibuprofen derivatives with reduced gastrotoxicity

Journal of Medicinal Chemistry

Volumn 44, Issue 21, 2001, Pages 3463-3468

  Lolli, M L ^a   Cena, C ^a   Medana, C ^a   Lazzarato, L ^a   Morini, G ^b   Coruzzi, G ^b   Manarini, S ^c   Fruttero, R ^a   Gasco, A ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(3 BENZENESULFONYL)FUROXAN 4 YLOXY]PROPYL 2 (4 ISOBUTYLPHENYL)PROPIONATE; 3 [3 (PHENYLTHIO)FUROXAN 4 YLOXY]PROPYL 2 (4 ISOBUTYLPHENYL)PROPIONATE; CARBOXYL GROUP; CARRAGEENAN; FURAZAN DERIVATIVE; FUROXAN DERIVATIVE; IBUPROFEN; IBUPROFEN DERIVATIVE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG HYDROLYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; NONHUMAN; PAW EDEMA; RAT; STOMACH MUCOSA; STOMACH ULCER; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION; ULCEROGENESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CYCLIC N-OXIDES; EDEMA; GASTRIC MUCOSA; HUMANS; IBUPROFEN; MALE; NITRIC OXIDE DONORS; OXADIAZOLES; PEPTIC ULCER; PLATELET AGGREGATION INHIBITORS; RATS; RATS, WISTAR;

EID: 0035846069     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0108799     Document Type: Article

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