Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 11, 2009, Pages 3829-3837

  Abdel Hafez, El Shimaa M N ^a   Abuo Rahma, Gamal El Din A A ^a   Abdel Aziz, Mohamed ^a   Radwan, Mohamed F ^a   Farag, Hassan H ^b  

^a Minia University   (Egypt)

^b Assiut University   (Egypt)

Author keywords

Anti inflammatory; Antibacterial; Histopathological investigation; Nitrate esters; Nitric oxide donors; Oximes; Pyrazole 3 carboxylic acid; Ulcerogenicity

Indexed keywords

2 [4 (4 BENZOYL 1,5 DIPHENYL 1H PYRAZOLE 3 CARBONYL)PIPERAZIN 1 YL] 2 OXOETHYL NITRATE; 4 [[4 [HYDROXYIMINO (PHENYL)METHYL] 1,5 DIPHENYL 1H 3 PYRAZOLYLCARBONYL]AMINO]BENZOIC ACID; CARBOXYLIC ACID DERIVATIVE; CIPROFLOXACIN; ESTER DERIVATIVE; INDOMETACIN; N (4 CHLOROPHENYL) 4 [HYDROXYIMINO (PHENYL)METHYL] 1,5 DIPHENYL 1H 3 PYRAZOLECARBOXAMIDE; N (4 METHOXYPHENYL) 4 [HYDROXYIMINO (PHENYL)METHYL] 1,5 DIPHENYL 1H 3 PYRAZOLECARBOXAMIDE; NITRIC ACID DERIVATIVE; NITRIC OXIDE; NITRIC OXIDE DONOR; OXIME; PYRAZOLE 3 CARBOXYLIC ACID DERIVATIVE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ESCHERICHIA COLI; NONHUMAN; PSEUDOMONAS AERUGINOSA; RAT; STAPHYLOCOCCUS AUREUS; STOMACH ULCER;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; BACTERIA; CARBOXYLIC ACIDS; DRUG DESIGN; MOLECULAR STRUCTURE; NITRIC OXIDE; PYRAZOLES; RATS;

ESCHERICHIA COLI; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 65549103768     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.037     Document Type: Article

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