Role of nitric oxide in pathogenesis of aspirin-induced gastric mucosal damage in rats

Digestion

Volumn 59, Issue 4, 1998, Pages 298-307

  Takeuchi, Koji ^a   Yasuhiro, Tetsuya ^a   Asada, Yoko ^a   Sugawa, Yasunari ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Acid secretion; Aspirin; Gastric lesion; Nitric oxide; Rat

Indexed keywords

5 (2 HYDROXYPROPOXY) 4 OXO 8 PROPYL 4H 1 BENZOPYRAN 2 CARBOXYLIC ACID; ACETYLSALICYLIC ACID; ARGININE; CIMETIDINE; HYDROCHLORIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEAFFERENTATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PATHOGENESIS; POTENTIAL DIFFERENCE; PRIORITY JOURNAL; RAT; STOMACH ACID SECRETION; STOMACH BLOOD FLOW; STOMACH HEMORRHAGE; STOMACH MUCOSA INJURY; STOMACH PH;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BLOOD FLOW VELOCITY; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GASTRIC ACID; GASTRIC MUCOSA; HYDROGEN-ION CONCENTRATION; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER;

EID: 0031856591     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000007506     Document Type: Article

References (34)

1. Davenport HW: Gastric mucosal hemorrhage in dogs:. Effect of acid, aspirin and alcohol. Gastroenterology 1969;56:439-449.
2. Lanza FL: Endoscopie studies of gastric and duodenal injury after the use of ibuprofen, aspirin, and other nonsteroidal antiinflammatory agents. Am J Med 1984;13:19-24.
3. Menguy R, Masters YF: Effect of aspirin on gastric mucous secretion. Surg Gynec Obstet 1965;120:92-97.
4. O'Brien P, Silen W: Effect of bile salts and aspirin on the gastric mucosal blood flow. Gastroenterology 1973;64:246-252.
5. Okabe S, Takeuchi K, Nakamura K, Takagi K: Pathogenesis of gastric lesions induced by aspirin in the pylorus-ligated rats. Jpn J Pharmacol 1974;24:36 3-371.
6. Whittle BJR, Higgs GA, Eakins KE, Moncada S, Vane JR: Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature 1980;284:271-273.
7. Takeuchi K, Ohuchi T, Okabe S: Endogenous nitric oxide in gastric alkaline response in the rat stomach after damage. Gastroenterology 1994;106:367-374.
8. Takeuchi K, Takehara K, Kaneko T, Okabe S: Nitric oxide and prostaglandins in regulation of acid secretory response in rat stomach following injury. J Pharmacol Exp Ther 1995;272: 357-363.
9. Takeuchi K, Kato S, Yasuhiro T, Yagi K: Capsaicin-sensitive sensory neurons and mucosal mast cells in regulation of acid secretion in rat stomach after damage. Dig Dis Sci 1997;42: 645-653.
10. MacNaughton WK, Cirino G, Wallace JL: Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach. Life Sci 1989;45:1869-1876.
11. Kitagawa H, Takeda F, Kohei H: Effect of endothelium-derived relaxing factor on the gastric lesion induced by HC1 in rats. J Pharmacol Exp Ther 1990;253:1133-1137.
12. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: Physiology, pathophysioiogy and pharmacology, Pharmacol Rev 1991;43:109-142.
13. Whittle BJR, Lopez-Belmonte J, Moncada S: Regulation of gastric mucosal integrity by endogenous nitric oxide: Interactions with prostaglandins and sensory neuropeptides in the rat. Br J Pharmacol 1990;99:607-611.
14. Takeuchi K, Ohtsuki H, Nakagawa S, Okabe S: Characterization of FPL-52694 [5-(2-hydroxypropyl)-8-propyl-4-oxo-4H-benzopyran-2-carboxylic acid Na] on histamine release from rat peritoneal mast cells induced by antigen, compound 48/80 and A23187. Agents Actions 1985;17:10-13.
15. Beck PL, Morris GP, Wallace JL: Reduction of ethanol-induced gastric damage by sodium cromoglycate and FPL-52694: Role of leukotrienes, prostaglandins, and mast cells in the protective mechanism. Can J Physiol Pharmacol 1988;67:287-294.
16. Matsumoto J, Takeuchi K, Ueshima K, Okabe S: Role of capsaicin-sensitive afferent neurons in mucosal blood flow response of rat stomach induced by mild irritants. Dig Dis Sci 1992;37: 1336-1344.
17. Takeuchi K, Ishihara Y, Okada M, Niida H, Okabe S: A continuous monitoring of mucosal integrity and secretory activity in rat stomach: A preparation using a lucite chamber. Jpn J Pharmacol 1988;49:235-244.
18. N-nitrate in biological fluids. Anal Biochem 1982;126:131-138.
19. Takeuchi K, Ueki S, Tanaka H: Endogenous prostaglandins in gastric alkaline response in the rat stomach after damage. Am J Physiol 1986;250:G842-G849.
20. 2: Intravenous, oral and intrajejunal administration. Gastroenterology 1976;70:359-370.
21. Wallace JL, McKnight W, Soldato PD, Baydoun AR, Cirino G: Antithrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative. J Clin Invest 1995;96:2711-2718.
22. Robert A, Leung FW, Kaiser DG, Guth PH: Potentiation of aspirin-induced gastric lesions by exposure to cold in rats: Role of acid secretion, mucosal blood flow, and gastric mucosal prostanoid content. Gastroenterology 1989;97: 1147-1158.
23. Takeuchi K, Ohuchi T, Kato S, Okabe S: Cytoprotective action of L-arginine against HCl-induced gastric injury in rats: Involvement of nitric oxide? Jpn J Pharmacol 1993;61:13-21.
24. Tepperman BL, Whittle BJR: Endogenous nitric oxide and sensory neuropeptides interact in the modulation of the rat gastric microcirculation. Br J Pharmacol 1992;105:171-175.
25. Lippe ThI, Holzer P: Participation of endothelium-derived nitric oxide but not prostacyclin in the gastric mucosal hyperemia due to acid back-diffusion. Br J Pharmacol 1992;105:708-714.
26. Thompson MR: Studies on the acid secretion that occurs during injury to the gastric mucosa. Gastroenterology 1976;71:286-290.
27. Johnson LR, Overholt BF: Release of histamine into gastric venous blood following injury by acetic or salicylic acid. Gastroenterology 1967;52:505-509.
28. Hirshowitz BI, Keeling D, Lewin M, Okabe S, Parsons M, Sewing K, Wallmark B, Sachs G: Pharmacological aspects of acid secretion. Dig Dis Sci 1995;40:S13-S23.
29. Holzer P, Sametz W: Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons. Gastroenterology 1986;91:975-981.
30. Li DS, Raybould HE, Quintero E, Guth PH: Role of calcitonin gene-related peptide in gastric hyperemic response to intragastric capsaicin. Am J Physiol 1991;261:G657-G661.
31. Lambrecht N, Burchert M, Respondek M, Muller KM, Peskar BM: Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat. Gastroenterology 1993;104:1371-1380.
32. Stead RH, Dixon MF, Brammwell NH, Riddell RH, Bienenstock J: Mast cells are closely apposed to nerves in the human gastrointestinal mucosa. Gastroenterology 1989;97:575-581.
33. Gronbech JE, Lacy ER: Substance P attenuates gastric mucosal hyperemia after stimulation of sensory neurons in the rat stomach. Gastroenterology 1994;106:440-449.
34. Ukawa H, Tanaka Y, Yamamoto H, Nishijima M, Takeuchi K: Effects of NO-releasing aspirin on functional and mucosal ulcerogenic responses in the rat stomach: Comparison with aspirin (abstract). Gastroenterology 1998; in press.